Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies

Abstract Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light. Cone and rod photoreceptors form images and send the information via retinal ganglion cells to the...

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Autores principales:	Megumi Hatori, Claude Gronfier, Russell N. Van Gelder, Paul S. Bernstein, Josep Carreras, Satchidananda Panda, Frederick Marks, David Sliney, Charles E. Hunt, Tsuyoshi Hirota, Toshiharu Furukawa, Kazuo Tsubota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e1f01dadb21d4a31baea49f066195609
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spelling	oai:doaj.org-article:e1f01dadb21d4a31baea49f0661956092021-12-02T14:18:31ZGlobal rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies10.1038/s41514-017-0010-22056-3973https://doaj.org/article/e1f01dadb21d4a31baea49f0661956092017-06-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0010-2https://doaj.org/toc/2056-3973Abstract Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light. Cone and rod photoreceptors form images and send the information via retinal ganglion cells to the brain for image reconstruction. In contrast, nonimage-forming photoresponses vary widely from adjustment of pupil diameter to adaptation of the circadian clock. nonimage-forming responses are mediated by retinal ganglion cells expressing the photopigment melanopsin. Melanopsin-expressing cells constitute 1–2% of retinal ganglion cells in the adult mammalian retina, are intrinsically photosensitive, and integrate photic information from rods and cones to control nonimage-forming adaptation. Action spectra of ipRGCs and of melanopsin photopigment peak around 480 nm blue light. Understanding melanopsin function lets us recognize considerable physiological effects of blue light, which is increasingly important in our modern society that uses light-emitting diode. Misalignment of circadian rhythmicity is observed in numerous conditions, including aging, and is thought to be involved in the development of age-related disorders, such as depression, diabetes, hypertension, obesity, and cancer. The appropriate regulation of circadian rhythmicity by proper lighting is therefore essential. This perspective introduces the potential risks of excessive blue light for human health through circadian rhythm disruption and sleep deprivation. Knowing the positive and negative aspects, this study claims the importance of being exposed to light at optimal times and intensities during the day, based on the concept of the circadian clock, ultimately to improve quality of life to have a healthy and longer life.Megumi HatoriClaude GronfierRussell N. Van GelderPaul S. BernsteinJosep CarrerasSatchidananda PandaFrederick MarksDavid SlineyCharles E. HuntTsuyoshi HirotaToshiharu FurukawaKazuo TsubotaNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-3 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Megumi Hatori Claude Gronfier Russell N. Van Gelder Paul S. Bernstein Josep Carreras Satchidananda Panda Frederick Marks David Sliney Charles E. Hunt Tsuyoshi Hirota Toshiharu Furukawa Kazuo Tsubota Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies
description	Abstract Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light. Cone and rod photoreceptors form images and send the information via retinal ganglion cells to the brain for image reconstruction. In contrast, nonimage-forming photoresponses vary widely from adjustment of pupil diameter to adaptation of the circadian clock. nonimage-forming responses are mediated by retinal ganglion cells expressing the photopigment melanopsin. Melanopsin-expressing cells constitute 1–2% of retinal ganglion cells in the adult mammalian retina, are intrinsically photosensitive, and integrate photic information from rods and cones to control nonimage-forming adaptation. Action spectra of ipRGCs and of melanopsin photopigment peak around 480 nm blue light. Understanding melanopsin function lets us recognize considerable physiological effects of blue light, which is increasingly important in our modern society that uses light-emitting diode. Misalignment of circadian rhythmicity is observed in numerous conditions, including aging, and is thought to be involved in the development of age-related disorders, such as depression, diabetes, hypertension, obesity, and cancer. The appropriate regulation of circadian rhythmicity by proper lighting is therefore essential. This perspective introduces the potential risks of excessive blue light for human health through circadian rhythm disruption and sleep deprivation. Knowing the positive and negative aspects, this study claims the importance of being exposed to light at optimal times and intensities during the day, based on the concept of the circadian clock, ultimately to improve quality of life to have a healthy and longer life.
format	article
author	Megumi Hatori Claude Gronfier Russell N. Van Gelder Paul S. Bernstein Josep Carreras Satchidananda Panda Frederick Marks David Sliney Charles E. Hunt Tsuyoshi Hirota Toshiharu Furukawa Kazuo Tsubota
author_facet	Megumi Hatori Claude Gronfier Russell N. Van Gelder Paul S. Bernstein Josep Carreras Satchidananda Panda Frederick Marks David Sliney Charles E. Hunt Tsuyoshi Hirota Toshiharu Furukawa Kazuo Tsubota
author_sort	Megumi Hatori
title	Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies
title_short	Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies
title_full	Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies
title_fullStr	Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies
title_full_unstemmed	Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies
title_sort	global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e1f01dadb21d4a31baea49f066195609
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Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies

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