Translational utility of experimental autoimmune encephalomyelitis: recent developments

Andre Ortlieb Guerreiro-Cacais, Hannes Laaksonen, Sevasti Flytzani, Marie N'diaye, Tomas Olsson, Maja Jagodic Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden Abstract: Multiple sclerosis (MS) is a complex aut...

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Autores principales:	Guerreiro-Cacais AO, Laaksonen H, Flytzani S, N’diaye M, Olsson T, Jagodic M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e1f092adaa3644159f00982c3b1a8ce8
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spelling	oai:doaj.org-article:e1f092adaa3644159f00982c3b1a8ce82021-12-02T07:50:55ZTranslational utility of experimental autoimmune encephalomyelitis: recent developments1178-7031https://doaj.org/article/e1f092adaa3644159f00982c3b1a8ce82015-11-01T00:00:00Zhttps://www.dovepress.com/translational-utility-of-experimental-autoimmune-encephalomyelitis-rec-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Andre Ortlieb Guerreiro-Cacais, Hannes Laaksonen, Sevasti Flytzani, Marie N'diaye, Tomas Olsson, Maja Jagodic Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden Abstract: Multiple sclerosis (MS) is a complex autoimmune condition with firmly established genetic and environmental components. Genome-wide association studies (GWAS) have revealed a large number of genetic polymorphisms in the vicinity of, and within, genes that associate to disease. However, the significance of these single-nucleotide polymorphisms in disease and possible mechanisms of action remain, with a few exceptions, to be established. While the animal model for MS, experimental autoimmune encephalomyelitis (EAE), has been instrumental in understanding immunity in general and mechanisms of MS disease in particular, much of the translational information gathered from the model in terms of treatment development (glatiramer acetate and natalizumab) has been extensively summarized. In this review, we would thus like to cover the work done in EAE from a GWAS perspective, highlighting the research that has addressed the role of different GWAS genes and their pathways in EAE pathogenesis. Understanding the contribution of these pathways to disease might allow for the stratification of disease subphenotypes in patients and in turn open the possibility for new and individualized treatment approaches in the future. Keywords: autoimmunity, multiple sclerosis, risk genes, EAE, knockouts, pathways Guerreiro-Cacais AOLaaksonen HFlytzani SN’diaye MOlsson TJagodic MDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2015, Iss default, Pp 211-225 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Guerreiro-Cacais AO Laaksonen H Flytzani S N’diaye M Olsson T Jagodic M Translational utility of experimental autoimmune encephalomyelitis: recent developments
description	Andre Ortlieb Guerreiro-Cacais, Hannes Laaksonen, Sevasti Flytzani, Marie N'diaye, Tomas Olsson, Maja Jagodic Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden Abstract: Multiple sclerosis (MS) is a complex autoimmune condition with firmly established genetic and environmental components. Genome-wide association studies (GWAS) have revealed a large number of genetic polymorphisms in the vicinity of, and within, genes that associate to disease. However, the significance of these single-nucleotide polymorphisms in disease and possible mechanisms of action remain, with a few exceptions, to be established. While the animal model for MS, experimental autoimmune encephalomyelitis (EAE), has been instrumental in understanding immunity in general and mechanisms of MS disease in particular, much of the translational information gathered from the model in terms of treatment development (glatiramer acetate and natalizumab) has been extensively summarized. In this review, we would thus like to cover the work done in EAE from a GWAS perspective, highlighting the research that has addressed the role of different GWAS genes and their pathways in EAE pathogenesis. Understanding the contribution of these pathways to disease might allow for the stratification of disease subphenotypes in patients and in turn open the possibility for new and individualized treatment approaches in the future. Keywords: autoimmunity, multiple sclerosis, risk genes, EAE, knockouts, pathways
format	article
author	Guerreiro-Cacais AO Laaksonen H Flytzani S N’diaye M Olsson T Jagodic M
author_facet	Guerreiro-Cacais AO Laaksonen H Flytzani S N’diaye M Olsson T Jagodic M
author_sort	Guerreiro-Cacais AO
title	Translational utility of experimental autoimmune encephalomyelitis: recent developments
title_short	Translational utility of experimental autoimmune encephalomyelitis: recent developments
title_full	Translational utility of experimental autoimmune encephalomyelitis: recent developments
title_fullStr	Translational utility of experimental autoimmune encephalomyelitis: recent developments
title_full_unstemmed	Translational utility of experimental autoimmune encephalomyelitis: recent developments
title_sort	translational utility of experimental autoimmune encephalomyelitis: recent developments
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e1f092adaa3644159f00982c3b1a8ce8
work_keys_str_mv	AT guerreirocacaisao translationalutilityofexperimentalautoimmuneencephalomyelitisrecentdevelopments AT laaksonenh translationalutilityofexperimentalautoimmuneencephalomyelitisrecentdevelopments AT flytzanis translationalutilityofexperimentalautoimmuneencephalomyelitisrecentdevelopments AT ndiayem translationalutilityofexperimentalautoimmuneencephalomyelitisrecentdevelopments AT olssont translationalutilityofexperimentalautoimmuneencephalomyelitisrecentdevelopments AT jagodicm translationalutilityofexperimentalautoimmuneencephalomyelitisrecentdevelopments
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Translational utility of experimental autoimmune encephalomyelitis: recent developments

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