Fluorescent light energy modulates healing in skin grafted mouse model

Skin grafting is often the only treatment for skin trauma when large areas of tissue are affected. This surgical intervention damages the deeper dermal layers of the skin with implications for wound healing and a risk of scar development. Photobiomodulation (PBM) therapy modulates biological process...

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Autores principales:	Ding Jie, Mellergaard Maiken, Zhu Zhensen, Kwan Peter, Edge Deirdre, Ma Zengshuan, Hebert Lise, Alrobaiea Saad, Iwasaki Takashi, Nielsen Michael Canova Engelbrecht, Tredget Edward E.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	skin grafting dermal fibrotic mouse model fluorescent light energy photobiomodulation wound healing Medicine R
Acceso en línea:	https://doaj.org/article/e1f147c5b17c4a8ca2de2d943b0d3024
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spelling	oai:doaj.org-article:e1f147c5b17c4a8ca2de2d943b0d30242021-12-05T14:10:55ZFluorescent light energy modulates healing in skin grafted mouse model2391-546310.1515/med-2021-0329https://doaj.org/article/e1f147c5b17c4a8ca2de2d943b0d30242021-08-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0329https://doaj.org/toc/2391-5463Skin grafting is often the only treatment for skin trauma when large areas of tissue are affected. This surgical intervention damages the deeper dermal layers of the skin with implications for wound healing and a risk of scar development. Photobiomodulation (PBM) therapy modulates biological processes in different tissues, with a positive effect on many cell types and pathways essential for wound healing. This study investigated the effect of fluorescent light energy (FLE) therapy, a novel type of PBM, on healing after skin grafting in a dermal fibrotic mouse model. Split-thickness human skin grafts were transplanted onto full-thickness excisional wounds on nude mice. Treated wounds were monitored, and excised xenografts were examined to assess healing and pathophysiological processes essential for developing chronic wounds or scarring. Results demonstrated that FLE treatment initially accelerated re-epithelialization and rete ridge formation, while later reduced neovascularization, collagen deposition, myofibroblast and mast cell accumulation, and connective tissue growth factor expression. While there was no visible difference in gross morphology, we found that FLE treatment promoted a balanced collagen remodeling. Collectively, these findings suggest that FLE has a conceivable effect at balancing healing after skin grafting, which reduces the risk of infections, chronic wound development, and fibrotic scarring.Ding JieMellergaard MaikenZhu ZhensenKwan PeterEdge DeirdreMa ZengshuanHebert LiseAlrobaiea SaadIwasaki TakashiNielsen Michael Canova EngelbrechtTredget Edward E.De Gruyterarticleskin graftingdermal fibrotic mouse modelfluorescent light energyphotobiomodulationwound healingMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1240-1255 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin grafting dermal fibrotic mouse model fluorescent light energy photobiomodulation wound healing Medicine R
spellingShingle	skin grafting dermal fibrotic mouse model fluorescent light energy photobiomodulation wound healing Medicine R Ding Jie Mellergaard Maiken Zhu Zhensen Kwan Peter Edge Deirdre Ma Zengshuan Hebert Lise Alrobaiea Saad Iwasaki Takashi Nielsen Michael Canova Engelbrecht Tredget Edward E. Fluorescent light energy modulates healing in skin grafted mouse model
description	Skin grafting is often the only treatment for skin trauma when large areas of tissue are affected. This surgical intervention damages the deeper dermal layers of the skin with implications for wound healing and a risk of scar development. Photobiomodulation (PBM) therapy modulates biological processes in different tissues, with a positive effect on many cell types and pathways essential for wound healing. This study investigated the effect of fluorescent light energy (FLE) therapy, a novel type of PBM, on healing after skin grafting in a dermal fibrotic mouse model. Split-thickness human skin grafts were transplanted onto full-thickness excisional wounds on nude mice. Treated wounds were monitored, and excised xenografts were examined to assess healing and pathophysiological processes essential for developing chronic wounds or scarring. Results demonstrated that FLE treatment initially accelerated re-epithelialization and rete ridge formation, while later reduced neovascularization, collagen deposition, myofibroblast and mast cell accumulation, and connective tissue growth factor expression. While there was no visible difference in gross morphology, we found that FLE treatment promoted a balanced collagen remodeling. Collectively, these findings suggest that FLE has a conceivable effect at balancing healing after skin grafting, which reduces the risk of infections, chronic wound development, and fibrotic scarring.
format	article
author	Ding Jie Mellergaard Maiken Zhu Zhensen Kwan Peter Edge Deirdre Ma Zengshuan Hebert Lise Alrobaiea Saad Iwasaki Takashi Nielsen Michael Canova Engelbrecht Tredget Edward E.
author_facet	Ding Jie Mellergaard Maiken Zhu Zhensen Kwan Peter Edge Deirdre Ma Zengshuan Hebert Lise Alrobaiea Saad Iwasaki Takashi Nielsen Michael Canova Engelbrecht Tredget Edward E.
author_sort	Ding Jie
title	Fluorescent light energy modulates healing in skin grafted mouse model
title_short	Fluorescent light energy modulates healing in skin grafted mouse model
title_full	Fluorescent light energy modulates healing in skin grafted mouse model
title_fullStr	Fluorescent light energy modulates healing in skin grafted mouse model
title_full_unstemmed	Fluorescent light energy modulates healing in skin grafted mouse model
title_sort	fluorescent light energy modulates healing in skin grafted mouse model
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/e1f147c5b17c4a8ca2de2d943b0d3024
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Fluorescent light energy modulates healing in skin grafted mouse model

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