Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface

How mutations in β3-tubulin cause axonal growth defects in congenital fibrosis of the extraocular muscles type 3 remains elusive. Minoura et al. develop a model system using recombinant human tubulin that demonstrates a link between tubulin mutation, impaired kinesin motility and axonal growth defec...

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Autores principales:	Itsushi Minoura, Hiroko Takazaki, Rie Ayukawa, Chihiro Saruta, You Hachikubo, Seiichi Uchimura, Tomonobu Hida, Hiroyuki Kamiguchi, Tomomi Shimogori, Etsuko Muto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1f2163676ed4f4f9ecb892722c22875
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spelling	oai:doaj.org-article:e1f2163676ed4f4f9ecb892722c228752021-12-02T15:34:57ZReversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface10.1038/ncomms100582041-1723https://doaj.org/article/e1f2163676ed4f4f9ecb892722c228752016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10058https://doaj.org/toc/2041-1723How mutations in β3-tubulin cause axonal growth defects in congenital fibrosis of the extraocular muscles type 3 remains elusive. Minoura et al. develop a model system using recombinant human tubulin that demonstrates a link between tubulin mutation, impaired kinesin motility and axonal growth defects.Itsushi MinouraHiroko TakazakiRie AyukawaChihiro SarutaYou HachikuboSeiichi UchimuraTomonobu HidaHiroyuki KamiguchiTomomi ShimogoriEtsuko MutoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Itsushi Minoura Hiroko Takazaki Rie Ayukawa Chihiro Saruta You Hachikubo Seiichi Uchimura Tomonobu Hida Hiroyuki Kamiguchi Tomomi Shimogori Etsuko Muto Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface
description	How mutations in β3-tubulin cause axonal growth defects in congenital fibrosis of the extraocular muscles type 3 remains elusive. Minoura et al. develop a model system using recombinant human tubulin that demonstrates a link between tubulin mutation, impaired kinesin motility and axonal growth defects.
format	article
author	Itsushi Minoura Hiroko Takazaki Rie Ayukawa Chihiro Saruta You Hachikubo Seiichi Uchimura Tomonobu Hida Hiroyuki Kamiguchi Tomomi Shimogori Etsuko Muto
author_facet	Itsushi Minoura Hiroko Takazaki Rie Ayukawa Chihiro Saruta You Hachikubo Seiichi Uchimura Tomonobu Hida Hiroyuki Kamiguchi Tomomi Shimogori Etsuko Muto
author_sort	Itsushi Minoura
title	Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface
title_short	Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface
title_full	Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface
title_fullStr	Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface
title_full_unstemmed	Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface
title_sort	reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e1f2163676ed4f4f9ecb892722c22875
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Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface

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