Delayed and progressive damages to juvenile mice after moderate traumatic brain injury

Abstract Symptoms are commonly more severe in pediatric traumatic brain injury (TBI) patients than in young adult TBI patients. To understand the mechanism, juvenile mice received a controlled cortical impact (CCI) injury at moderate level. Tissue lesion and cell death were measured and compared to...

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Autores principales:	Shu Zhao, Xiaoting Wang, Xiang Gao, Jinhui Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e1f6755b67864288be45b2416b7bda2e
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spelling	oai:doaj.org-article:e1f6755b67864288be45b2416b7bda2e2021-12-02T16:08:15ZDelayed and progressive damages to juvenile mice after moderate traumatic brain injury10.1038/s41598-018-25475-92045-2322https://doaj.org/article/e1f6755b67864288be45b2416b7bda2e2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25475-9https://doaj.org/toc/2045-2322Abstract Symptoms are commonly more severe in pediatric traumatic brain injury (TBI) patients than in young adult TBI patients. To understand the mechanism, juvenile mice received a controlled cortical impact (CCI) injury at moderate level. Tissue lesion and cell death were measured and compared to our previous reports on brain injury in the young adult mice that received same level of impact using same injury device. Tissue lesion and cell death in the cortex was much less in the juvenile mouse brain in the first few hours after injury. However, once the injury occurred, it developed more rapidly, lasted much longer, and eventually led to exaggerated cell death and a 32.7% larger tissue lesion cavity in the cortex of juvenile mouse brain than of young adult mouse brain. Moreover, we found significant cell death in the thalamus of juvenile brains at 72 h, which was not commonly seen in the young adult mice. In summary, cell death in juvenile mice was delayed, lasted longer, and finally resulted in more severe brain injury than in the young adult mice. The results suggest that pediatric TBI patients may have a longer therapeutic window, but they also need longer intensive clinical care after injury.Shu ZhaoXiaoting WangXiang GaoJinhui ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shu Zhao Xiaoting Wang Xiang Gao Jinhui Chen Delayed and progressive damages to juvenile mice after moderate traumatic brain injury
description	Abstract Symptoms are commonly more severe in pediatric traumatic brain injury (TBI) patients than in young adult TBI patients. To understand the mechanism, juvenile mice received a controlled cortical impact (CCI) injury at moderate level. Tissue lesion and cell death were measured and compared to our previous reports on brain injury in the young adult mice that received same level of impact using same injury device. Tissue lesion and cell death in the cortex was much less in the juvenile mouse brain in the first few hours after injury. However, once the injury occurred, it developed more rapidly, lasted much longer, and eventually led to exaggerated cell death and a 32.7% larger tissue lesion cavity in the cortex of juvenile mouse brain than of young adult mouse brain. Moreover, we found significant cell death in the thalamus of juvenile brains at 72 h, which was not commonly seen in the young adult mice. In summary, cell death in juvenile mice was delayed, lasted longer, and finally resulted in more severe brain injury than in the young adult mice. The results suggest that pediatric TBI patients may have a longer therapeutic window, but they also need longer intensive clinical care after injury.
format	article
author	Shu Zhao Xiaoting Wang Xiang Gao Jinhui Chen
author_facet	Shu Zhao Xiaoting Wang Xiang Gao Jinhui Chen
author_sort	Shu Zhao
title	Delayed and progressive damages to juvenile mice after moderate traumatic brain injury
title_short	Delayed and progressive damages to juvenile mice after moderate traumatic brain injury
title_full	Delayed and progressive damages to juvenile mice after moderate traumatic brain injury
title_fullStr	Delayed and progressive damages to juvenile mice after moderate traumatic brain injury
title_full_unstemmed	Delayed and progressive damages to juvenile mice after moderate traumatic brain injury
title_sort	delayed and progressive damages to juvenile mice after moderate traumatic brain injury
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e1f6755b67864288be45b2416b7bda2e
work_keys_str_mv	AT shuzhao delayedandprogressivedamagestojuvenilemiceaftermoderatetraumaticbraininjury AT xiaotingwang delayedandprogressivedamagestojuvenilemiceaftermoderatetraumaticbraininjury AT xianggao delayedandprogressivedamagestojuvenilemiceaftermoderatetraumaticbraininjury AT jinhuichen delayedandprogressivedamagestojuvenilemiceaftermoderatetraumaticbraininjury
_version_	1718384565227094016

Delayed and progressive damages to juvenile mice after moderate traumatic brain injury

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