Conserved amino acid networks modulate discrete functional properties in an enzyme superfamily
Abstract In this work, we applied the sequence-based statistical coupling analysis approach to characterize conserved amino acid networks important for biochemical function in the pancreatic-type ribonuclease (ptRNase) superfamily. This superfamily-wide analysis indicates a decomposition of the RNas...
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Auteurs principaux: | Chitra Narayanan, Donald Gagné, Kimberly A. Reynolds, Nicolas Doucet |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2017
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Accès en ligne: | https://doaj.org/article/e1f69c4e9b494b9dbefb82876d0eca19 |
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