Genome-wide mapping of loci explaining variance in scrotal circumference in Nellore cattle.
The reproductive performance of bulls has a high impact on the beef cattle industry. Scrotal circumference (SC) is the most recorded reproductive trait in beef herds, and is used as a major selection criterion to improve precocity and fertility. The characterization of genomic regions affecting SC c...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/e1f99b4571894e139b27b82421c086cf |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:e1f99b4571894e139b27b82421c086cf |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:e1f99b4571894e139b27b82421c086cf2021-11-18T08:32:18ZGenome-wide mapping of loci explaining variance in scrotal circumference in Nellore cattle.1932-620310.1371/journal.pone.0088561https://doaj.org/article/e1f99b4571894e139b27b82421c086cf2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24558400/?tool=EBIhttps://doaj.org/toc/1932-6203The reproductive performance of bulls has a high impact on the beef cattle industry. Scrotal circumference (SC) is the most recorded reproductive trait in beef herds, and is used as a major selection criterion to improve precocity and fertility. The characterization of genomic regions affecting SC can contribute to the identification of diagnostic markers for reproductive performance and uncover molecular mechanisms underlying complex aspects of bovine reproductive biology. In this paper, we report a genome-wide scan for chromosome segments explaining differences in SC, using data of 861 Nellore bulls (Bos indicus) genotyped for over 777,000 single nucleotide polymorphisms. Loci that excel from the genome background were identified on chromosomes 4, 6, 7, 10, 14, 18 and 21. The majority of these regions were previously found to be associated with reproductive and body size traits in cattle. The signal on chromosome 14 replicates the pleiotropic quantitative trait locus encompassing PLAG1 that affects male fertility in cattle and stature in several species. Based on intensive literature mining, SP4, MAGEL2, SH3RF2, PDE5A and SNAI2 are proposed as novel candidate genes for SC, as they affect growth and testicular size in other animal models. These findings contribute to linking reproductive phenotypes to gene functions, and may offer new insights on the molecular biology of male fertility.Yuri T UtsunomiyaAdriana S CarmoHaroldo H R NevesRoberto CarvalheiroMárcia C MatosLudmilla B ZavarezPier K R K ItoAna M Pérez O'BrienJohann SölknerLaercio R Porto-NetoFlávio S SchenkelJohn McEwanJohn B ColeMarcos V G B da SilvaCurtis P Van TassellTad S SonstegardJosé Fernando GarciaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88561 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Yuri T Utsunomiya Adriana S Carmo Haroldo H R Neves Roberto Carvalheiro Márcia C Matos Ludmilla B Zavarez Pier K R K Ito Ana M Pérez O'Brien Johann Sölkner Laercio R Porto-Neto Flávio S Schenkel John McEwan John B Cole Marcos V G B da Silva Curtis P Van Tassell Tad S Sonstegard José Fernando Garcia Genome-wide mapping of loci explaining variance in scrotal circumference in Nellore cattle. |
| description |
The reproductive performance of bulls has a high impact on the beef cattle industry. Scrotal circumference (SC) is the most recorded reproductive trait in beef herds, and is used as a major selection criterion to improve precocity and fertility. The characterization of genomic regions affecting SC can contribute to the identification of diagnostic markers for reproductive performance and uncover molecular mechanisms underlying complex aspects of bovine reproductive biology. In this paper, we report a genome-wide scan for chromosome segments explaining differences in SC, using data of 861 Nellore bulls (Bos indicus) genotyped for over 777,000 single nucleotide polymorphisms. Loci that excel from the genome background were identified on chromosomes 4, 6, 7, 10, 14, 18 and 21. The majority of these regions were previously found to be associated with reproductive and body size traits in cattle. The signal on chromosome 14 replicates the pleiotropic quantitative trait locus encompassing PLAG1 that affects male fertility in cattle and stature in several species. Based on intensive literature mining, SP4, MAGEL2, SH3RF2, PDE5A and SNAI2 are proposed as novel candidate genes for SC, as they affect growth and testicular size in other animal models. These findings contribute to linking reproductive phenotypes to gene functions, and may offer new insights on the molecular biology of male fertility. |
| format |
article |
| author |
Yuri T Utsunomiya Adriana S Carmo Haroldo H R Neves Roberto Carvalheiro Márcia C Matos Ludmilla B Zavarez Pier K R K Ito Ana M Pérez O'Brien Johann Sölkner Laercio R Porto-Neto Flávio S Schenkel John McEwan John B Cole Marcos V G B da Silva Curtis P Van Tassell Tad S Sonstegard José Fernando Garcia |
| author_facet |
Yuri T Utsunomiya Adriana S Carmo Haroldo H R Neves Roberto Carvalheiro Márcia C Matos Ludmilla B Zavarez Pier K R K Ito Ana M Pérez O'Brien Johann Sölkner Laercio R Porto-Neto Flávio S Schenkel John McEwan John B Cole Marcos V G B da Silva Curtis P Van Tassell Tad S Sonstegard José Fernando Garcia |
| author_sort |
Yuri T Utsunomiya |
| title |
Genome-wide mapping of loci explaining variance in scrotal circumference in Nellore cattle. |
| title_short |
Genome-wide mapping of loci explaining variance in scrotal circumference in Nellore cattle. |
| title_full |
Genome-wide mapping of loci explaining variance in scrotal circumference in Nellore cattle. |
| title_fullStr |
Genome-wide mapping of loci explaining variance in scrotal circumference in Nellore cattle. |
| title_full_unstemmed |
Genome-wide mapping of loci explaining variance in scrotal circumference in Nellore cattle. |
| title_sort |
genome-wide mapping of loci explaining variance in scrotal circumference in nellore cattle. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/e1f99b4571894e139b27b82421c086cf |
| work_keys_str_mv |
AT yuritutsunomiya genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT adrianascarmo genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT haroldohrneves genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT robertocarvalheiro genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT marciacmatos genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT ludmillabzavarez genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT pierkrkito genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT anamperezobrien genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT johannsolkner genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT laerciorportoneto genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT flaviosschenkel genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT johnmcewan genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT johnbcole genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT marcosvgbdasilva genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT curtispvantassell genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT tadssonstegard genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle AT josefernandogarcia genomewidemappingoflociexplainingvarianceinscrotalcircumferenceinnellorecattle |
| _version_ |
1718421714960908288 |