Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to both protect and adjuvant vaccine antigens for ora...

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Autores principales:	Marianela C. Serradell, Lucía L. Rupil, Román A. Martino, César G. Prucca, Pedro G. Carranza, Alicia Saura, Elmer A. Fernández, Pablo R. Gargantini, Albano H. Tenaglia, Juan P. Petiti, Renata R. Tonelli, Nicolás Reinoso-Vizcaino, José Echenique, Luciana Berod, Eliane Piaggio, Bertrand Bellier, Tim Sparwasser, David Klatzmann, Hugo D. Luján
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1faa7844c394e018f3b0bfaf2625985
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spelling	oai:doaj.org-article:e1faa7844c394e018f3b0bfaf26259852021-12-02T14:40:00ZEfficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins10.1038/s41467-018-08265-92041-1723https://doaj.org/article/e1faa7844c394e018f3b0bfaf26259852019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08265-9https://doaj.org/toc/2041-1723Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to both protect and adjuvant vaccine antigens for oral administration.Marianela C. SerradellLucía L. RupilRomán A. MartinoCésar G. PruccaPedro G. CarranzaAlicia SauraElmer A. FernándezPablo R. GargantiniAlbano H. TenagliaJuan P. PetitiRenata R. TonelliNicolás Reinoso-VizcainoJosé EcheniqueLuciana BerodEliane PiaggioBertrand BellierTim SparwasserDavid KlatzmannHugo D. LujánNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marianela C. Serradell Lucía L. Rupil Román A. Martino César G. Prucca Pedro G. Carranza Alicia Saura Elmer A. Fernández Pablo R. Gargantini Albano H. Tenaglia Juan P. Petiti Renata R. Tonelli Nicolás Reinoso-Vizcaino José Echenique Luciana Berod Eliane Piaggio Bertrand Bellier Tim Sparwasser David Klatzmann Hugo D. Luján Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
description	Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to both protect and adjuvant vaccine antigens for oral administration.
format	article
author	Marianela C. Serradell Lucía L. Rupil Román A. Martino César G. Prucca Pedro G. Carranza Alicia Saura Elmer A. Fernández Pablo R. Gargantini Albano H. Tenaglia Juan P. Petiti Renata R. Tonelli Nicolás Reinoso-Vizcaino José Echenique Luciana Berod Eliane Piaggio Bertrand Bellier Tim Sparwasser David Klatzmann Hugo D. Luján
author_facet	Marianela C. Serradell Lucía L. Rupil Román A. Martino César G. Prucca Pedro G. Carranza Alicia Saura Elmer A. Fernández Pablo R. Gargantini Albano H. Tenaglia Juan P. Petiti Renata R. Tonelli Nicolás Reinoso-Vizcaino José Echenique Luciana Berod Eliane Piaggio Bertrand Bellier Tim Sparwasser David Klatzmann Hugo D. Luján
author_sort	Marianela C. Serradell
title	Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
title_short	Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
title_full	Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
title_fullStr	Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
title_full_unstemmed	Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
title_sort	efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e1faa7844c394e018f3b0bfaf2625985
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Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

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