Granzyme B inhibition reduces disease severity in autoimmune blistering diseases

Pemphigoid diseases involve autoimmune mediated blistering and immunopathology of the upper dermis. Here, the authors implicate granzyme B in the immunopathology in multiple in vivo models of pemphigoid diseases and utilise a topical granzyme B inhibitor that attenuates disease phenotypes in vivo.

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Autores principales:	Sho Hiroyasu, Matthew R. Zeglinski, Hongyan Zhao, Megan A. Pawluk, Christopher T. Turner, Anika Kasprick, Chiharu Tateishi, Wataru Nishie, Angela Burleigh, Peter A. Lennox, Nancy Van Laeken, Nick J. Carr, Frank Petersen, Richard I. Crawford, Hiroshi Shimizu, Daisuke Tsuruta, Ralf J. Ludwig, David J. Granville
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e1fcb0e4655740288ff9814e14e03085
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spelling	oai:doaj.org-article:e1fcb0e4655740288ff9814e14e030852021-12-02T14:11:51ZGranzyme B inhibition reduces disease severity in autoimmune blistering diseases10.1038/s41467-020-20604-32041-1723https://doaj.org/article/e1fcb0e4655740288ff9814e14e030852021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20604-3https://doaj.org/toc/2041-1723Pemphigoid diseases involve autoimmune mediated blistering and immunopathology of the upper dermis. Here, the authors implicate granzyme B in the immunopathology in multiple in vivo models of pemphigoid diseases and utilise a topical granzyme B inhibitor that attenuates disease phenotypes in vivo.Sho HiroyasuMatthew R. ZeglinskiHongyan ZhaoMegan A. PawlukChristopher T. TurnerAnika KasprickChiharu TateishiWataru NishieAngela BurleighPeter A. LennoxNancy Van LaekenNick J. CarrFrank PetersenRichard I. CrawfordHiroshi ShimizuDaisuke TsurutaRalf J. LudwigDavid J. GranvilleNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sho Hiroyasu Matthew R. Zeglinski Hongyan Zhao Megan A. Pawluk Christopher T. Turner Anika Kasprick Chiharu Tateishi Wataru Nishie Angela Burleigh Peter A. Lennox Nancy Van Laeken Nick J. Carr Frank Petersen Richard I. Crawford Hiroshi Shimizu Daisuke Tsuruta Ralf J. Ludwig David J. Granville Granzyme B inhibition reduces disease severity in autoimmune blistering diseases
description	Pemphigoid diseases involve autoimmune mediated blistering and immunopathology of the upper dermis. Here, the authors implicate granzyme B in the immunopathology in multiple in vivo models of pemphigoid diseases and utilise a topical granzyme B inhibitor that attenuates disease phenotypes in vivo.
format	article
author	Sho Hiroyasu Matthew R. Zeglinski Hongyan Zhao Megan A. Pawluk Christopher T. Turner Anika Kasprick Chiharu Tateishi Wataru Nishie Angela Burleigh Peter A. Lennox Nancy Van Laeken Nick J. Carr Frank Petersen Richard I. Crawford Hiroshi Shimizu Daisuke Tsuruta Ralf J. Ludwig David J. Granville
author_facet	Sho Hiroyasu Matthew R. Zeglinski Hongyan Zhao Megan A. Pawluk Christopher T. Turner Anika Kasprick Chiharu Tateishi Wataru Nishie Angela Burleigh Peter A. Lennox Nancy Van Laeken Nick J. Carr Frank Petersen Richard I. Crawford Hiroshi Shimizu Daisuke Tsuruta Ralf J. Ludwig David J. Granville
author_sort	Sho Hiroyasu
title	Granzyme B inhibition reduces disease severity in autoimmune blistering diseases
title_short	Granzyme B inhibition reduces disease severity in autoimmune blistering diseases
title_full	Granzyme B inhibition reduces disease severity in autoimmune blistering diseases
title_fullStr	Granzyme B inhibition reduces disease severity in autoimmune blistering diseases
title_full_unstemmed	Granzyme B inhibition reduces disease severity in autoimmune blistering diseases
title_sort	granzyme b inhibition reduces disease severity in autoimmune blistering diseases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e1fcb0e4655740288ff9814e14e03085
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Granzyme B inhibition reduces disease severity in autoimmune blistering diseases

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