Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach

Abstract Alzheimer disease (AD) is a neurodegenerative disorder with an –as of yet– unclear etiology and pathogenesis. Research to unveil disease processes underlying AD often relies on the use of neurodegenerative disease model organisms, such as Caenorhabditis elegans. This study sought to identif...

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Autores principales:	Avgi E. Apostolakou, Xhuliana K. Sula, Katerina C. Nastou, Georgia I. Nasi, Vassiliki A. Iconomidou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e1fe35932ecc455c9f0eb345f3234039
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spelling	oai:doaj.org-article:e1fe35932ecc455c9f0eb345f32340392021-12-02T15:54:03ZExploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach10.1038/s41598-021-83892-92045-2322https://doaj.org/article/e1fe35932ecc455c9f0eb345f32340392021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83892-9https://doaj.org/toc/2045-2322Abstract Alzheimer disease (AD) is a neurodegenerative disorder with an –as of yet– unclear etiology and pathogenesis. Research to unveil disease processes underlying AD often relies on the use of neurodegenerative disease model organisms, such as Caenorhabditis elegans. This study sought to identify biological pathways implicated in AD that are conserved in Homo sapiens and C. elegans. Protein–protein interaction networks were assembled for amyloid precursor protein (APP) and Tau in H. sapiens—two proteins whose aggregation is a hallmark in AD—and their orthologs APL-1 and PTL-1 for C. elegans. Global network alignment was used to compare these networks and determine similar, likely conserved, network regions. This comparison revealed that two prominent pathways, the APP-processing and the Tau-phosphorylation pathways, are highly conserved in both organisms. While the majority of interactions between proteins in those pathways are known to be associated with AD in human, they remain unexamined in C. elegans, signifying the need for their further investigation. In this work, we have highlighted conserved interactions related to AD in humans and have identified specific proteins that can act as targets for experimental studies in C. elegans, aiming to uncover the underlying mechanisms of AD.Avgi E. ApostolakouXhuliana K. SulaKaterina C. NastouGeorgia I. NasiVassiliki A. IconomidouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Avgi E. Apostolakou Xhuliana K. Sula Katerina C. Nastou Georgia I. Nasi Vassiliki A. Iconomidou Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach
description	Abstract Alzheimer disease (AD) is a neurodegenerative disorder with an –as of yet– unclear etiology and pathogenesis. Research to unveil disease processes underlying AD often relies on the use of neurodegenerative disease model organisms, such as Caenorhabditis elegans. This study sought to identify biological pathways implicated in AD that are conserved in Homo sapiens and C. elegans. Protein–protein interaction networks were assembled for amyloid precursor protein (APP) and Tau in H. sapiens—two proteins whose aggregation is a hallmark in AD—and their orthologs APL-1 and PTL-1 for C. elegans. Global network alignment was used to compare these networks and determine similar, likely conserved, network regions. This comparison revealed that two prominent pathways, the APP-processing and the Tau-phosphorylation pathways, are highly conserved in both organisms. While the majority of interactions between proteins in those pathways are known to be associated with AD in human, they remain unexamined in C. elegans, signifying the need for their further investigation. In this work, we have highlighted conserved interactions related to AD in humans and have identified specific proteins that can act as targets for experimental studies in C. elegans, aiming to uncover the underlying mechanisms of AD.
format	article
author	Avgi E. Apostolakou Xhuliana K. Sula Katerina C. Nastou Georgia I. Nasi Vassiliki A. Iconomidou
author_facet	Avgi E. Apostolakou Xhuliana K. Sula Katerina C. Nastou Georgia I. Nasi Vassiliki A. Iconomidou
author_sort	Avgi E. Apostolakou
title	Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach
title_short	Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach
title_full	Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach
title_fullStr	Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach
title_full_unstemmed	Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach
title_sort	exploring the conservation of alzheimer-related pathways between h. sapiens and c. elegans: a network alignment approach
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e1fe35932ecc455c9f0eb345f3234039
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Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach

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