Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children

ObjectiveTo investigate the correlation between serum immunoglobulin E (IgE) levels and the complications in children with Mycoplasma pneumoniae pneumonia (MPP).MethodsA retrospective study of MPP patients hospitalized from May 2019 to July 2021 was performed. We analyzed the clinical manifestations...

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Autores principales:	Lili Zhou, Yuan Li, Zhufei Xu, Xuyun Peng, Xiaoyan Gong, Lin Yang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Children Immunoglobulin E Mycoplasma pneumoniae Severe Mycoplasma pneumoniae pneumonia complications Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e1ff282a6d334d4685736a218906f37e
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spelling	oai:doaj.org-article:e1ff282a6d334d4685736a218906f37e2021-11-30T19:15:58ZIncreased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children2235-298810.3389/fcimb.2021.783635https://doaj.org/article/e1ff282a6d334d4685736a218906f37e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.783635/fullhttps://doaj.org/toc/2235-2988ObjectiveTo investigate the correlation between serum immunoglobulin E (IgE) levels and the complications in children with Mycoplasma pneumoniae pneumonia (MPP).MethodsA retrospective study of MPP patients hospitalized from May 2019 to July 2021 was performed. We analyzed the clinical manifestations, complications, laboratory findings, and treatments.ResultsA total of 275 patients who met the inclusion criteria were enrolled in the study. We divided patients into two groups based on whether there were complications. Complications occurred in 147 patients, of which pulmonary complications were more common than extrapulmonary complications. The IgE level in the complication group was higher than that in the non-complication group with p = 0.041. Patients with complications of necrotizing pneumonitis, pneumothorax, skin rash, or bronchiolitis obliterans had higher IgE levels. There was no statistically significant difference in IgE levels between pulmonary complications and extrapulmonary complications. The older the age, the greater the probability of complications (p = 0.001). The group with complications was more likely to have chest pain (p = 0.000), while the group without complications was more likely to have wheezing (p = 0.017). The use of bronchoscopy and glucocorticoids was higher in the complication group than in the non-complication group (p = 0.000).ConclusionsMPP patients with higher IgE levels had more severe clinical symptoms and complications. We speculated that IgE might be a biomarker for complications after MP infection.Lili ZhouYuan LiZhufei XuXuyun PengXiaoyan GongLin YangFrontiers Media S.A.articleChildrenImmunoglobulin EMycoplasma pneumoniaeSevere Mycoplasma pneumoniae pneumoniacomplicationsMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Children Immunoglobulin E Mycoplasma pneumoniae Severe Mycoplasma pneumoniae pneumonia complications Microbiology QR1-502
spellingShingle	Children Immunoglobulin E Mycoplasma pneumoniae Severe Mycoplasma pneumoniae pneumonia complications Microbiology QR1-502 Lili Zhou Yuan Li Zhufei Xu Xuyun Peng Xiaoyan Gong Lin Yang Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children
description	ObjectiveTo investigate the correlation between serum immunoglobulin E (IgE) levels and the complications in children with Mycoplasma pneumoniae pneumonia (MPP).MethodsA retrospective study of MPP patients hospitalized from May 2019 to July 2021 was performed. We analyzed the clinical manifestations, complications, laboratory findings, and treatments.ResultsA total of 275 patients who met the inclusion criteria were enrolled in the study. We divided patients into two groups based on whether there were complications. Complications occurred in 147 patients, of which pulmonary complications were more common than extrapulmonary complications. The IgE level in the complication group was higher than that in the non-complication group with p = 0.041. Patients with complications of necrotizing pneumonitis, pneumothorax, skin rash, or bronchiolitis obliterans had higher IgE levels. There was no statistically significant difference in IgE levels between pulmonary complications and extrapulmonary complications. The older the age, the greater the probability of complications (p = 0.001). The group with complications was more likely to have chest pain (p = 0.000), while the group without complications was more likely to have wheezing (p = 0.017). The use of bronchoscopy and glucocorticoids was higher in the complication group than in the non-complication group (p = 0.000).ConclusionsMPP patients with higher IgE levels had more severe clinical symptoms and complications. We speculated that IgE might be a biomarker for complications after MP infection.
format	article
author	Lili Zhou Yuan Li Zhufei Xu Xuyun Peng Xiaoyan Gong Lin Yang
author_facet	Lili Zhou Yuan Li Zhufei Xu Xuyun Peng Xiaoyan Gong Lin Yang
author_sort	Lili Zhou
title	Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children
title_short	Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children
title_full	Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children
title_fullStr	Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children
title_full_unstemmed	Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children
title_sort	increased total serum immunoglobulin e is likely to cause complications of mycoplasma pneumoniae pneumonia in children
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e1ff282a6d334d4685736a218906f37e
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Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children

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