Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents

Abstract Deep eutectic solvents have been recently reported as an interesting alternative to improve the therapeutic efficacy of conventional drugs, hence called therapeutic deep eutectic solvents (THEDES). The main objective of this work was to evaluate the potential of limonene (LIM) based THEDES...

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Autores principales:	Carolina V. Pereira, Joana M. Silva, Liliana Rodrigues, Rui L. Reis, Alexandre Paiva, Ana Rita C. Duarte, Ana Matias
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e1ff8dc6abe849ea80e24783adfc0a76
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spelling	oai:doaj.org-article:e1ff8dc6abe849ea80e24783adfc0a762021-12-02T15:09:46ZUnveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents10.1038/s41598-019-51472-72045-2322https://doaj.org/article/e1ff8dc6abe849ea80e24783adfc0a762019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-51472-7https://doaj.org/toc/2045-2322Abstract Deep eutectic solvents have been recently reported as an interesting alternative to improve the therapeutic efficacy of conventional drugs, hence called therapeutic deep eutectic solvents (THEDES). The main objective of this work was to evaluate the potential of limonene (LIM) based THEDES as new possible systems for cancer treatment. LIM is known to have antitumor activity, however it is highly toxic and cell viability is often compromised, thus this compound is not selective towards cancer cells. Different THEDES based on LIM were developed to unravel the anticancer potential of such systems. THEDES were prepared by gently mixing saturated fatty acids menthol or ibuprofen (IBU) with LIM. Successful THEDES were obtained for Menthol:LIM (1:1), CA:LIM (1:1), IBU:LIM (1:4) and IBU:LIM(1:8). The results indicate that all the THEDES present antiproliferative properties, but IBU:LIM (1:4) was the only formulation able to inhibit HT29 proliferation without comprising cell viability. Therefore, IBU:LIM (1:4) was the formulation selected for further assessment of anticancer properties. The results suggest that the mechanism of action of LIM:IBU (1:4) is different from isolated IBU and LIM, which suggest the synergetic effect of DES. In this work, we unravel a methodology to tune the selectivity of LIM towards HT29 cell line without compromising cell viability of healthy cells. We demonstrate furthermore that coupling LIM with IBU leads also to an enhancement of the anti-inflammatory activity of IBU, which may be important in anti-cancer therapies.Carolina V. PereiraJoana M. SilvaLiliana RodriguesRui L. ReisAlexandre PaivaAna Rita C. DuarteAna MatiasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carolina V. Pereira Joana M. Silva Liliana Rodrigues Rui L. Reis Alexandre Paiva Ana Rita C. Duarte Ana Matias Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents
description	Abstract Deep eutectic solvents have been recently reported as an interesting alternative to improve the therapeutic efficacy of conventional drugs, hence called therapeutic deep eutectic solvents (THEDES). The main objective of this work was to evaluate the potential of limonene (LIM) based THEDES as new possible systems for cancer treatment. LIM is known to have antitumor activity, however it is highly toxic and cell viability is often compromised, thus this compound is not selective towards cancer cells. Different THEDES based on LIM were developed to unravel the anticancer potential of such systems. THEDES were prepared by gently mixing saturated fatty acids menthol or ibuprofen (IBU) with LIM. Successful THEDES were obtained for Menthol:LIM (1:1), CA:LIM (1:1), IBU:LIM (1:4) and IBU:LIM(1:8). The results indicate that all the THEDES present antiproliferative properties, but IBU:LIM (1:4) was the only formulation able to inhibit HT29 proliferation without comprising cell viability. Therefore, IBU:LIM (1:4) was the formulation selected for further assessment of anticancer properties. The results suggest that the mechanism of action of LIM:IBU (1:4) is different from isolated IBU and LIM, which suggest the synergetic effect of DES. In this work, we unravel a methodology to tune the selectivity of LIM towards HT29 cell line without compromising cell viability of healthy cells. We demonstrate furthermore that coupling LIM with IBU leads also to an enhancement of the anti-inflammatory activity of IBU, which may be important in anti-cancer therapies.
format	article
author	Carolina V. Pereira Joana M. Silva Liliana Rodrigues Rui L. Reis Alexandre Paiva Ana Rita C. Duarte Ana Matias
author_facet	Carolina V. Pereira Joana M. Silva Liliana Rodrigues Rui L. Reis Alexandre Paiva Ana Rita C. Duarte Ana Matias
author_sort	Carolina V. Pereira
title	Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents
title_short	Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents
title_full	Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents
title_fullStr	Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents
title_full_unstemmed	Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents
title_sort	unveil the anticancer potential of limomene based therapeutic deep eutectic solvents
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e1ff8dc6abe849ea80e24783adfc0a76
work_keys_str_mv	AT carolinavpereira unveiltheanticancerpotentialoflimomenebasedtherapeuticdeepeutecticsolvents AT joanamsilva unveiltheanticancerpotentialoflimomenebasedtherapeuticdeepeutecticsolvents AT lilianarodrigues unveiltheanticancerpotentialoflimomenebasedtherapeuticdeepeutecticsolvents AT ruilreis unveiltheanticancerpotentialoflimomenebasedtherapeuticdeepeutecticsolvents AT alexandrepaiva unveiltheanticancerpotentialoflimomenebasedtherapeuticdeepeutecticsolvents AT anaritacduarte unveiltheanticancerpotentialoflimomenebasedtherapeuticdeepeutecticsolvents AT anamatias unveiltheanticancerpotentialoflimomenebasedtherapeuticdeepeutecticsolvents
_version_	1718387785519333376

Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solvents

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