Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

Expression and activation of Heat shock factor 1 (HSF1) in cancer associated fibroblasts have been associated with protumorigenic functions. Here the authors show that, in a model of colitis-induced colorectal cancer, HSF1 is activated in stromal fibroblasts in the early stages of inflammation, lead...

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Autores principales:	Oshrat Levi-Galibov, Hagar Lavon, Rina Wassermann-Dozorets, Meirav Pevsner-Fischer, Shimrit Mayer, Esther Wershof, Yaniv Stein, Lauren E. Brown, Wenhan Zhang, Gil Friedman, Reinat Nevo, Ofra Golani, Lior H. Katz, Rona Yaeger, Ido Laish, John A. Porco, Erik Sahai, Dror S. Shouval, David Kelsen, Ruth Scherz-Shouval
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2082e39466448b09082f3deb8fc453c
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spelling	oai:doaj.org-article:e2082e39466448b09082f3deb8fc453c2021-12-02T14:16:55ZHeat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer10.1038/s41467-020-20054-x2041-1723https://doaj.org/article/e2082e39466448b09082f3deb8fc453c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20054-xhttps://doaj.org/toc/2041-1723Expression and activation of Heat shock factor 1 (HSF1) in cancer associated fibroblasts have been associated with protumorigenic functions. Here the authors show that, in a model of colitis-induced colorectal cancer, HSF1 is activated in stromal fibroblasts in the early stages of inflammation, leading to extracellular matrix remodelling that sustains tumor initiation and progression.Oshrat Levi-GalibovHagar LavonRina Wassermann-DozoretsMeirav Pevsner-FischerShimrit MayerEsther WershofYaniv SteinLauren E. BrownWenhan ZhangGil FriedmanReinat NevoOfra GolaniLior H. KatzRona YaegerIdo LaishJohn A. PorcoErik SahaiDror S. ShouvalDavid KelsenRuth Scherz-ShouvalNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oshrat Levi-Galibov Hagar Lavon Rina Wassermann-Dozorets Meirav Pevsner-Fischer Shimrit Mayer Esther Wershof Yaniv Stein Lauren E. Brown Wenhan Zhang Gil Friedman Reinat Nevo Ofra Golani Lior H. Katz Rona Yaeger Ido Laish John A. Porco Erik Sahai Dror S. Shouval David Kelsen Ruth Scherz-Shouval Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
description	Expression and activation of Heat shock factor 1 (HSF1) in cancer associated fibroblasts have been associated with protumorigenic functions. Here the authors show that, in a model of colitis-induced colorectal cancer, HSF1 is activated in stromal fibroblasts in the early stages of inflammation, leading to extracellular matrix remodelling that sustains tumor initiation and progression.
format	article
author	Oshrat Levi-Galibov Hagar Lavon Rina Wassermann-Dozorets Meirav Pevsner-Fischer Shimrit Mayer Esther Wershof Yaniv Stein Lauren E. Brown Wenhan Zhang Gil Friedman Reinat Nevo Ofra Golani Lior H. Katz Rona Yaeger Ido Laish John A. Porco Erik Sahai Dror S. Shouval David Kelsen Ruth Scherz-Shouval
author_facet	Oshrat Levi-Galibov Hagar Lavon Rina Wassermann-Dozorets Meirav Pevsner-Fischer Shimrit Mayer Esther Wershof Yaniv Stein Lauren E. Brown Wenhan Zhang Gil Friedman Reinat Nevo Ofra Golani Lior H. Katz Rona Yaeger Ido Laish John A. Porco Erik Sahai Dror S. Shouval David Kelsen Ruth Scherz-Shouval
author_sort	Oshrat Levi-Galibov
title	Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
title_short	Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
title_full	Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
title_fullStr	Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
title_full_unstemmed	Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
title_sort	heat shock factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e2082e39466448b09082f3deb8fc453c
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Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer

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