Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression

Ahmad H Alghadir ,1 Sami A Gabr 1 Rehabilitation Research Chair (RRC), College of Applied Medical Sciences (CAMS), King Saud University, Riyadh, Kingdom of Saudi ArabiaCorrespondence: Sami A GabrRehabilitation Research Chair (RRC), College of Applied Medical Sciences (CAMS), King Saud University, P....

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Autores principales:	Alghadir AH, Gabr SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	adrenal function depression lpta aerobic exercise poms. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e20c5123069d47e19907abbcc865ee08
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spelling	oai:doaj.org-article:e20c5123069d47e19907abbcc865ee082021-12-02T12:58:37ZHormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression1178-1998https://doaj.org/article/e20c5123069d47e19907abbcc865ee082020-08-01T00:00:00Zhttps://www.dovepress.com/hormonal-function-responses-to-moderate-aerobic-exercise-in-older-adul-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ahmad H Alghadir ,1 Sami A Gabr 1 Rehabilitation Research Chair (RRC), College of Applied Medical Sciences (CAMS), King Saud University, Riyadh, Kingdom of Saudi ArabiaCorrespondence: Sami A GabrRehabilitation Research Chair (RRC), College of Applied Medical Sciences (CAMS), King Saud University, P.O. Box 10219, Riyadh 11433, Kingdom of Saudi ArabiaTel +966 562060018Fax +966 14698541Email dr.samigabr@gmail.comBackground: Poor daily life physical activities among older people were related to depressive mood especially memory loss. In addition to that, the change in physical ability is significantly associated with the score of depression among older age.Objective: The present study aimed to evaluate the effects of a supervised aerobic training program with moderate intensity for 12 weeks on mood profiles and hormonal levels of the hypothalamus-pituitary-adrenal axis (HPA axis) of older adults.Methods: A total of 80 individuals of both gender (90 males, 110 females) of ages ranged between 65 and 95 years were recruited for this study. Based upon the profile of mood states (POMS) analysis, the participants were classified into two groups: control group (n=30) and depressive group (n=50). Leisure-time physical activity (LTPA), adrenal hormones such as ACTH, corticosterone (CORT), cortisol, DHEA/S, and cortisol:DHEA/S ratio were measured at baseline and post-intervention of moderate aerobic exercise for 12 weeks.Results: Older adults with higher depressive scores showed a remarkable change in the level of adrenal hormones compared to control. There was a significant increase in the level of ACTH, CORT, cortisol, and cortisol:DHEA/S ratio, and decrease in DHEA/S. Compared to females, males showed an improvement in depressive mood score along with an increase in LPTA, DHEA/S and decrease in ACTH, CORT, cortisol, cortisol:DHEA/S ratio following 12 weeks of supervised aerobic training, respectively.Conclusion: The findings of this study showed that 12 weeks of supervised exercise interventions are promising non-drug therapeutic strategies in improving depression among older adults. The potential performance in a psychological state occurs physiologically via optimizing the levels of the hormones of the HPA axis.Keywords: adrenal function, depression, LPTA, aerobic exercise, POMSAlghadir AHGabr SADove Medical Pressarticleadrenal functiondepressionlptaaerobic exercisepoms.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 1271-1283 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	adrenal function depression lpta aerobic exercise poms. Geriatrics RC952-954.6
spellingShingle	adrenal function depression lpta aerobic exercise poms. Geriatrics RC952-954.6 Alghadir AH Gabr SA Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression
description	Ahmad H Alghadir ,1 Sami A Gabr 1 Rehabilitation Research Chair (RRC), College of Applied Medical Sciences (CAMS), King Saud University, Riyadh, Kingdom of Saudi ArabiaCorrespondence: Sami A GabrRehabilitation Research Chair (RRC), College of Applied Medical Sciences (CAMS), King Saud University, P.O. Box 10219, Riyadh 11433, Kingdom of Saudi ArabiaTel +966 562060018Fax +966 14698541Email dr.samigabr@gmail.comBackground: Poor daily life physical activities among older people were related to depressive mood especially memory loss. In addition to that, the change in physical ability is significantly associated with the score of depression among older age.Objective: The present study aimed to evaluate the effects of a supervised aerobic training program with moderate intensity for 12 weeks on mood profiles and hormonal levels of the hypothalamus-pituitary-adrenal axis (HPA axis) of older adults.Methods: A total of 80 individuals of both gender (90 males, 110 females) of ages ranged between 65 and 95 years were recruited for this study. Based upon the profile of mood states (POMS) analysis, the participants were classified into two groups: control group (n=30) and depressive group (n=50). Leisure-time physical activity (LTPA), adrenal hormones such as ACTH, corticosterone (CORT), cortisol, DHEA/S, and cortisol:DHEA/S ratio were measured at baseline and post-intervention of moderate aerobic exercise for 12 weeks.Results: Older adults with higher depressive scores showed a remarkable change in the level of adrenal hormones compared to control. There was a significant increase in the level of ACTH, CORT, cortisol, and cortisol:DHEA/S ratio, and decrease in DHEA/S. Compared to females, males showed an improvement in depressive mood score along with an increase in LPTA, DHEA/S and decrease in ACTH, CORT, cortisol, cortisol:DHEA/S ratio following 12 weeks of supervised aerobic training, respectively.Conclusion: The findings of this study showed that 12 weeks of supervised exercise interventions are promising non-drug therapeutic strategies in improving depression among older adults. The potential performance in a psychological state occurs physiologically via optimizing the levels of the hormones of the HPA axis.Keywords: adrenal function, depression, LPTA, aerobic exercise, POMS
format	article
author	Alghadir AH Gabr SA
author_facet	Alghadir AH Gabr SA
author_sort	Alghadir AH
title	Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression
title_short	Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression
title_full	Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression
title_fullStr	Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression
title_full_unstemmed	Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression
title_sort	hormonal function responses to moderate aerobic exercise in older adults with depression
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e20c5123069d47e19907abbcc865ee08
work_keys_str_mv	AT alghadirah hormonalfunctionresponsestomoderateaerobicexerciseinolderadultswithdepression AT gabrsa hormonalfunctionresponsestomoderateaerobicexerciseinolderadultswithdepression
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Hormonal Function Responses to Moderate Aerobic Exercise in Older Adults with Depression

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