Altered brain metabolic connectivity at multiscale level in early Parkinson’s disease

Abstract To explore the effects of PD pathology on brain connectivity, we characterized with an emergent computational approach the brain metabolic connectome using [18F]FDG-PET in early idiopathic PD patients. We applied whole-brain and pathology-based connectivity analyses, using sparse-inverse co...

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Autores principales:	Arianna Sala, Silvia Paola Caminiti, Luca Presotto, Enrico Premi, Andrea Pilotto, Rosanna Turrone, Maura Cosseddu, Antonella Alberici, Barbara Paghera, Barbara Borroni, Alessandro Padovani, Daniela Perani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e20c96cab1b840c5ab51996c9ee4898f
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spelling	oai:doaj.org-article:e20c96cab1b840c5ab51996c9ee4898f2021-12-02T12:32:13ZAltered brain metabolic connectivity at multiscale level in early Parkinson’s disease10.1038/s41598-017-04102-z2045-2322https://doaj.org/article/e20c96cab1b840c5ab51996c9ee4898f2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04102-zhttps://doaj.org/toc/2045-2322Abstract To explore the effects of PD pathology on brain connectivity, we characterized with an emergent computational approach the brain metabolic connectome using [18F]FDG-PET in early idiopathic PD patients. We applied whole-brain and pathology-based connectivity analyses, using sparse-inverse covariance estimation in thirty-four cognitively normal PD cases and thirty-four age-matched healthy subjects for comparisons. Further, we assessed high-order resting state networks by interregional correlation analysis. Whole-brain analysis revealed altered metabolic connectivity in PD, with local decreases in frontolateral cortex and cerebellum and increases in the basal ganglia. Widespread long-distance decreases were present within the frontolateral cortex as opposed to connectivity increases in posterior cortical regions, all suggestive of a global-scale connectivity reconfiguration. The pathology-based analyses revealed significant connectivity impairment in the nigrostriatal dopaminergic pathway and in the regions early affected by α-synuclein pathology. Notably, significant connectivity changes were present in several resting state networks especially in frontal regions. These findings expand previous imaging evidence of altered connectivity in cognitively stable PD patients by showing pathology-based connectivity changes and disease-specific metabolic architecture reconfiguration at multiple scale levels, from the earliest PD phases. These alterations go well beyond the known striato-cortical connectivity derangement supporting in vivo an extended neural vulnerability in the PD synucleinopathy.Arianna SalaSilvia Paola CaminitiLuca PresottoEnrico PremiAndrea PilottoRosanna TurroneMaura CossedduAntonella AlbericiBarbara PagheraBarbara BorroniAlessandro PadovaniDaniela PeraniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Arianna Sala Silvia Paola Caminiti Luca Presotto Enrico Premi Andrea Pilotto Rosanna Turrone Maura Cosseddu Antonella Alberici Barbara Paghera Barbara Borroni Alessandro Padovani Daniela Perani Altered brain metabolic connectivity at multiscale level in early Parkinson’s disease
description	Abstract To explore the effects of PD pathology on brain connectivity, we characterized with an emergent computational approach the brain metabolic connectome using [18F]FDG-PET in early idiopathic PD patients. We applied whole-brain and pathology-based connectivity analyses, using sparse-inverse covariance estimation in thirty-four cognitively normal PD cases and thirty-four age-matched healthy subjects for comparisons. Further, we assessed high-order resting state networks by interregional correlation analysis. Whole-brain analysis revealed altered metabolic connectivity in PD, with local decreases in frontolateral cortex and cerebellum and increases in the basal ganglia. Widespread long-distance decreases were present within the frontolateral cortex as opposed to connectivity increases in posterior cortical regions, all suggestive of a global-scale connectivity reconfiguration. The pathology-based analyses revealed significant connectivity impairment in the nigrostriatal dopaminergic pathway and in the regions early affected by α-synuclein pathology. Notably, significant connectivity changes were present in several resting state networks especially in frontal regions. These findings expand previous imaging evidence of altered connectivity in cognitively stable PD patients by showing pathology-based connectivity changes and disease-specific metabolic architecture reconfiguration at multiple scale levels, from the earliest PD phases. These alterations go well beyond the known striato-cortical connectivity derangement supporting in vivo an extended neural vulnerability in the PD synucleinopathy.
format	article
author	Arianna Sala Silvia Paola Caminiti Luca Presotto Enrico Premi Andrea Pilotto Rosanna Turrone Maura Cosseddu Antonella Alberici Barbara Paghera Barbara Borroni Alessandro Padovani Daniela Perani
author_facet	Arianna Sala Silvia Paola Caminiti Luca Presotto Enrico Premi Andrea Pilotto Rosanna Turrone Maura Cosseddu Antonella Alberici Barbara Paghera Barbara Borroni Alessandro Padovani Daniela Perani
author_sort	Arianna Sala
title	Altered brain metabolic connectivity at multiscale level in early Parkinson’s disease
title_short	Altered brain metabolic connectivity at multiscale level in early Parkinson’s disease
title_full	Altered brain metabolic connectivity at multiscale level in early Parkinson’s disease
title_fullStr	Altered brain metabolic connectivity at multiscale level in early Parkinson’s disease
title_full_unstemmed	Altered brain metabolic connectivity at multiscale level in early Parkinson’s disease
title_sort	altered brain metabolic connectivity at multiscale level in early parkinson’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e20c96cab1b840c5ab51996c9ee4898f
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Altered brain metabolic connectivity at multiscale level in early Parkinson’s disease

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