Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art

Mucus is a viscoelastic hydrogel that lubricates and protects mucosal tissues such as the eyes, lung, gastrointestinal tract, and vagina. Nanoparticle-based drug delivery systems (DDSs) can be easily trapped in the mucus network by steric obstruction and/or binding interactions and then are efficien...

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Autores principales:	Chang Liu, Xiaohe Jiang, Yong Gan, Miaorong Yu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Mucus barrier Mucosal drug delivery Nanoparticles Particle tracking experiments Mucus-penetrating nanoparticles Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/e211f9c5a04e4731a75b512b039d03e8
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spelling	oai:doaj.org-article:e211f9c5a04e4731a75b512b039d03e82021-12-04T04:35:47ZEngineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art2590-098610.1016/j.medidd.2021.100110https://doaj.org/article/e211f9c5a04e4731a75b512b039d03e82021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590098621000312https://doaj.org/toc/2590-0986Mucus is a viscoelastic hydrogel that lubricates and protects mucosal tissues such as the eyes, lung, gastrointestinal tract, and vagina. Nanoparticle-based drug delivery systems (DDSs) can be easily trapped in the mucus network by steric obstruction and/or binding interactions and then are efficiently cleared away with rapid mucus turnover, thereby limiting mucosal drug delivery efficacy. Modulating the physicochemical properties of nanoparticles (NPs), including size, surface hydrophilicity and charge, shape, and rigidity, is an effective method to overcome the mucus barrier. This review first describes the protective barrier properties of mucus and how mucus affects the fate of NPs. It then reviews the techniques for evaluating particle movement in mucus, including macroscopic diffusivity and microcosmic diffusion mechanisms. The state-of-the-art strategies exploited by researchers to overcome the mucus barrier by using NPs are discussed. Finally, the dilemma and solutions of balancing both mucus penetration and cellular uptake barriers are discussed.Chang LiuXiaohe JiangYong GanMiaorong YuElsevierarticleMucus barrierMucosal drug deliveryNanoparticlesParticle tracking experimentsMucus-penetrating nanoparticlesPharmacy and materia medicaRS1-441ENMedicine in Drug Discovery, Vol 12, Iss , Pp 100110- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mucus barrier Mucosal drug delivery Nanoparticles Particle tracking experiments Mucus-penetrating nanoparticles Pharmacy and materia medica RS1-441
spellingShingle	Mucus barrier Mucosal drug delivery Nanoparticles Particle tracking experiments Mucus-penetrating nanoparticles Pharmacy and materia medica RS1-441 Chang Liu Xiaohe Jiang Yong Gan Miaorong Yu Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art
description	Mucus is a viscoelastic hydrogel that lubricates and protects mucosal tissues such as the eyes, lung, gastrointestinal tract, and vagina. Nanoparticle-based drug delivery systems (DDSs) can be easily trapped in the mucus network by steric obstruction and/or binding interactions and then are efficiently cleared away with rapid mucus turnover, thereby limiting mucosal drug delivery efficacy. Modulating the physicochemical properties of nanoparticles (NPs), including size, surface hydrophilicity and charge, shape, and rigidity, is an effective method to overcome the mucus barrier. This review first describes the protective barrier properties of mucus and how mucus affects the fate of NPs. It then reviews the techniques for evaluating particle movement in mucus, including macroscopic diffusivity and microcosmic diffusion mechanisms. The state-of-the-art strategies exploited by researchers to overcome the mucus barrier by using NPs are discussed. Finally, the dilemma and solutions of balancing both mucus penetration and cellular uptake barriers are discussed.
format	article
author	Chang Liu Xiaohe Jiang Yong Gan Miaorong Yu
author_facet	Chang Liu Xiaohe Jiang Yong Gan Miaorong Yu
author_sort	Chang Liu
title	Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art
title_short	Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art
title_full	Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art
title_fullStr	Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art
title_full_unstemmed	Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art
title_sort	engineering nanoparticles to overcome the mucus barrier for drug delivery: design, evaluation and state-of-the-art
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/e211f9c5a04e4731a75b512b039d03e8
work_keys_str_mv	AT changliu engineeringnanoparticlestoovercomethemucusbarrierfordrugdeliverydesignevaluationandstateoftheart AT xiaohejiang engineeringnanoparticlestoovercomethemucusbarrierfordrugdeliverydesignevaluationandstateoftheart AT yonggan engineeringnanoparticlestoovercomethemucusbarrierfordrugdeliverydesignevaluationandstateoftheart AT miaorongyu engineeringnanoparticlestoovercomethemucusbarrierfordrugdeliverydesignevaluationandstateoftheart
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Engineering nanoparticles to overcome the mucus barrier for drug delivery: Design, evaluation and state-of-the-art

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