Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing

Primary cilia have been proposed to regulate glucose metabolism and insulin secretion in beta cells, but it is not known how. Here the authors show that primary cilia play a role in adult β-cell function via a mechanism involving endosomal EphA-processing.

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Detalles Bibliográficos
Autores principales: Francesco Volta, M. Julia Scerbo, Anett Seelig, Robert Wagner, Nils O’Brien, Felicia Gerst, Andreas Fritsche, Hans-Ulrich Häring, Anja Zeigerer, Susanne Ullrich, Jantje M. Gerdes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/e220d2e988ea4982b89164ece311375a
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Sumario:Primary cilia have been proposed to regulate glucose metabolism and insulin secretion in beta cells, but it is not known how. Here the authors show that primary cilia play a role in adult β-cell function via a mechanism involving endosomal EphA-processing.