Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing

Primary cilia have been proposed to regulate glucose metabolism and insulin secretion in beta cells, but it is not known how. Here the authors show that primary cilia play a role in adult β-cell function via a mechanism involving endosomal EphA-processing.

Guardado en:

Detalles Bibliográficos
Autores principales:	Francesco Volta, M. Julia Scerbo, Anett Seelig, Robert Wagner, Nils O’Brien, Felicia Gerst, Andreas Fritsche, Hans-Ulrich Häring, Anja Zeigerer, Susanne Ullrich, Jantje M. Gerdes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e220d2e988ea4982b89164ece311375a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e220d2e988ea4982b89164ece311375a
record_format	dspace
spelling	oai:doaj.org-article:e220d2e988ea4982b89164ece311375a2021-12-02T17:01:51ZGlucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing10.1038/s41467-019-12953-52041-1723https://doaj.org/article/e220d2e988ea4982b89164ece311375a2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12953-5https://doaj.org/toc/2041-1723Primary cilia have been proposed to regulate glucose metabolism and insulin secretion in beta cells, but it is not known how. Here the authors show that primary cilia play a role in adult β-cell function via a mechanism involving endosomal EphA-processing.Francesco VoltaM. Julia ScerboAnett SeeligRobert WagnerNils O’BrienFelicia GerstAndreas FritscheHans-Ulrich HäringAnja ZeigererSusanne UllrichJantje M. GerdesNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francesco Volta M. Julia Scerbo Anett Seelig Robert Wagner Nils O’Brien Felicia Gerst Andreas Fritsche Hans-Ulrich Häring Anja Zeigerer Susanne Ullrich Jantje M. Gerdes Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing
description	Primary cilia have been proposed to regulate glucose metabolism and insulin secretion in beta cells, but it is not known how. Here the authors show that primary cilia play a role in adult β-cell function via a mechanism involving endosomal EphA-processing.
format	article
author	Francesco Volta M. Julia Scerbo Anett Seelig Robert Wagner Nils O’Brien Felicia Gerst Andreas Fritsche Hans-Ulrich Häring Anja Zeigerer Susanne Ullrich Jantje M. Gerdes
author_facet	Francesco Volta M. Julia Scerbo Anett Seelig Robert Wagner Nils O’Brien Felicia Gerst Andreas Fritsche Hans-Ulrich Häring Anja Zeigerer Susanne Ullrich Jantje M. Gerdes
author_sort	Francesco Volta
title	Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing
title_short	Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing
title_full	Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing
title_fullStr	Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing
title_full_unstemmed	Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing
title_sort	glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal epha-processing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e220d2e988ea4982b89164ece311375a
work_keys_str_mv	AT francescovolta glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing AT mjuliascerbo glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing AT anettseelig glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing AT robertwagner glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing AT nilsobrien glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing AT feliciagerst glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing AT andreasfritsche glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing AT hansulrichharing glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing AT anjazeigerer glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing AT susanneullrich glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing AT jantjemgerdes glucosehomeostasisisregulatedbypancreaticbcellciliaviaendosomalephaprocessing
_version_	1718382054874284032

Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing

Ejemplares similares