Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing
Primary cilia have been proposed to regulate glucose metabolism and insulin secretion in beta cells, but it is not known how. Here the authors show that primary cilia play a role in adult β-cell function via a mechanism involving endosomal EphA-processing.
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Autores principales: | Francesco Volta, M. Julia Scerbo, Anett Seelig, Robert Wagner, Nils O’Brien, Felicia Gerst, Andreas Fritsche, Hans-Ulrich Häring, Anja Zeigerer, Susanne Ullrich, Jantje M. Gerdes |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/e220d2e988ea4982b89164ece311375a |
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