Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial

Joan Trabal,1 Maria Forga,1 Pere Leyes,1 Ferran Torres,2,3 Jordi Rubio,4 Esther Prieto,5 Andreu Farran-Codina6 1Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain; 2Biostatistics and Data Management Core Facility, IDIBAPS, Ho...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Trabal J, Forga M, Leyes P, Torres F, Rubio J, Prieto E, Farran-Codina A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Leucine Resistance Training Aged Muscle Strength Functional Status Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/e221000dc9ad48e5b3bffc74f50f0fc5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e221000dc9ad48e5b3bffc74f50f0fc5
record_format	dspace
spelling	oai:doaj.org-article:e221000dc9ad48e5b3bffc74f50f0fc52021-12-02T06:54:39ZEffects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial1178-1998https://doaj.org/article/e221000dc9ad48e5b3bffc74f50f0fc52015-04-01T00:00:00Zhttps://www.dovepress.com/effects-of-free-leucine-supplementation-and-resistance-training-on-mus-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Joan Trabal,1 Maria Forga,1 Pere Leyes,1 Ferran Torres,2,3 Jordi Rubio,4 Esther Prieto,5 Andreu Farran-Codina6 1Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain; 2Biostatistics and Data Management Core Facility, IDIBAPS, Hospital Clinic Universitari de Barcelona, Barcelona, Catalonia, Spain; 3Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain; 4Residencia Ballesol Almogavers, Grupo Ballesol, Barcelona, Catalonia, Spain; 5Centre de Rehabilitacio, Fundació Amiba, Badalona, Catalonia, Spain; 6Department of Nutrition and Food Science, Faculty of Pharmacy, Universitat de Barcelona, Barcelona, Catalonia, Spain Objective: To assess the effect of free leucine supplementation combined with resistance training versus resistance training only on muscle strength and functional status in older adults.Methods: This was a randomized, double-blind, placebo-controlled, parallel study with two intervention groups. Thirty older adults were randomly assigned to receive either 10 g leucine/day (leucine group [LG], n=15) or a placebo (control group [CG], n=15), plus resistance training over a 12-week period. Maximal overcoming isometric leg strength, functional status, nutritional status, body composition, health-related quality of life, depression, and dietary intake were assessed at 4 and 12 weeks. Missing data at 12 weeks were handled using mixed models for repeated measurements for data imputation.Results: Twenty-four subjects completed the 4-week assessment and eleven completed the 12-week intervention. Clinically significant gains were found in isometric leg strength at both assessment time points. Analysis of the effect size also showed how participants in LG outperformed those in CG for chair stands and the timed up and go test. No significant changes were observed for the rest of the outcomes.Conclusion: Our combined analysis showed moderate changes in isometric leg muscle strength and certain components of functional status. The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention. Keywords: aged, elderly, strength training, amino acid, functionalityTrabal JForga MLeyes PTorres FRubio JPrieto EFarran-Codina ADove Medical PressarticleLeucineResistance TrainingAgedMuscle StrengthFunctional StatusGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 713-723 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Leucine Resistance Training Aged Muscle Strength Functional Status Geriatrics RC952-954.6
spellingShingle	Leucine Resistance Training Aged Muscle Strength Functional Status Geriatrics RC952-954.6 Trabal J Forga M Leyes P Torres F Rubio J Prieto E Farran-Codina A Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial
description	Joan Trabal,1 Maria Forga,1 Pere Leyes,1 Ferran Torres,2,3 Jordi Rubio,4 Esther Prieto,5 Andreu Farran-Codina6 1Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain; 2Biostatistics and Data Management Core Facility, IDIBAPS, Hospital Clinic Universitari de Barcelona, Barcelona, Catalonia, Spain; 3Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain; 4Residencia Ballesol Almogavers, Grupo Ballesol, Barcelona, Catalonia, Spain; 5Centre de Rehabilitacio, Fundació Amiba, Badalona, Catalonia, Spain; 6Department of Nutrition and Food Science, Faculty of Pharmacy, Universitat de Barcelona, Barcelona, Catalonia, Spain Objective: To assess the effect of free leucine supplementation combined with resistance training versus resistance training only on muscle strength and functional status in older adults.Methods: This was a randomized, double-blind, placebo-controlled, parallel study with two intervention groups. Thirty older adults were randomly assigned to receive either 10 g leucine/day (leucine group [LG], n=15) or a placebo (control group [CG], n=15), plus resistance training over a 12-week period. Maximal overcoming isometric leg strength, functional status, nutritional status, body composition, health-related quality of life, depression, and dietary intake were assessed at 4 and 12 weeks. Missing data at 12 weeks were handled using mixed models for repeated measurements for data imputation.Results: Twenty-four subjects completed the 4-week assessment and eleven completed the 12-week intervention. Clinically significant gains were found in isometric leg strength at both assessment time points. Analysis of the effect size also showed how participants in LG outperformed those in CG for chair stands and the timed up and go test. No significant changes were observed for the rest of the outcomes.Conclusion: Our combined analysis showed moderate changes in isometric leg muscle strength and certain components of functional status. The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention. Keywords: aged, elderly, strength training, amino acid, functionality
format	article
author	Trabal J Forga M Leyes P Torres F Rubio J Prieto E Farran-Codina A
author_facet	Trabal J Forga M Leyes P Torres F Rubio J Prieto E Farran-Codina A
author_sort	Trabal J
title	Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial
title_short	Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial
title_full	Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial
title_fullStr	Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial
title_full_unstemmed	Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial
title_sort	effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e221000dc9ad48e5b3bffc74f50f0fc5
work_keys_str_mv	AT trabalj effectsoffreeleucinesupplementationandresistancetrainingonmusclestrengthandfunctionalstatusinolderadultsarandomizedcontrolledtrial AT forgam effectsoffreeleucinesupplementationandresistancetrainingonmusclestrengthandfunctionalstatusinolderadultsarandomizedcontrolledtrial AT leyesp effectsoffreeleucinesupplementationandresistancetrainingonmusclestrengthandfunctionalstatusinolderadultsarandomizedcontrolledtrial AT torresf effectsoffreeleucinesupplementationandresistancetrainingonmusclestrengthandfunctionalstatusinolderadultsarandomizedcontrolledtrial AT rubioj effectsoffreeleucinesupplementationandresistancetrainingonmusclestrengthandfunctionalstatusinolderadultsarandomizedcontrolledtrial AT prietoe effectsoffreeleucinesupplementationandresistancetrainingonmusclestrengthandfunctionalstatusinolderadultsarandomizedcontrolledtrial AT farrancodinaa effectsoffreeleucinesupplementationandresistancetrainingonmusclestrengthandfunctionalstatusinolderadultsarandomizedcontrolledtrial
_version_	1718399725006225408

Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial

Ejemplares similares