Cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.

<h4>Objective</h4>We aimed to evaluate cognitive function in adult offspring of women with diet-treated gestational diabetes and to study potential associations with maternal glucose values.<h4>Materials and methods</h4>In 2003-2005 cognitive function was assessed in a cohort...

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Autores principales:	Tine D Clausen, Erik L Mortensen, Lone Schmidt, Elisabeth R Mathiesen, Torben Hansen, Dorte M Jensen, Peter Damm
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e221bb24dbc844c6a817409da342808d
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spelling	oai:doaj.org-article:e221bb24dbc844c6a817409da342808d2021-11-18T07:39:32ZCognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.1932-620310.1371/journal.pone.0067107https://doaj.org/article/e221bb24dbc844c6a817409da342808d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23840595/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>We aimed to evaluate cognitive function in adult offspring of women with diet-treated gestational diabetes and to study potential associations with maternal glucose values.<h4>Materials and methods</h4>In 2003-2005 cognitive function was assessed in a cohort of 18-27 year old offspring of women with diet-treated gestational diabetes mellitus (n = 153) and offspring from the background population (n = 118). The main outcome measure was global cognitive score derived from Raven's Progressive Matrices and three verbal subtests from the Weschler Adult Intelligence Scale. Maternal fasting- and 2-hour blood glucose values from the diagnostic oral glucose tolerance test were used as exposure variables.<h4>Results</h4>Offspring of women with gestational diabetes mellitus had a lower global cognitive score, than offspring from the background population (93.1 vs. 100.0, P<0.001). However, when adjusted for maternal age at delivery, parity, smoking during pregnancy, pre-pregnancy overweight, family social class, parental educational level, gender, birth weight, gestational age, perinatal complications and offspring age at follow-up, the difference was no longer statistically significant. Offspring global cognitive score decreased significantly with increasing maternal fasting glucose (β = -4.5, 95% CI -8.0 to -0.9, P = 0.01) and 2-hour glucose (β = -1.5, -2.9 to -0.2, P = 0.03) in univariate general linear models, but not when adjusted for family social class and parental educational level.<h4>Conclusions</h4>Lower cognitive test scores in adult offspring of women with diet-treated gestational diabetes were explained by well known predictors of cognitive function, but not by maternal hyperglycaemia during pregnancy. We find it reassuring that mild intrauterine hyperglycaemia does not seem to have adverse effect on offspring cognitive function.Tine D ClausenErik L MortensenLone SchmidtElisabeth R MathiesenTorben HansenDorte M JensenPeter DammPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e67107 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tine D Clausen Erik L Mortensen Lone Schmidt Elisabeth R Mathiesen Torben Hansen Dorte M Jensen Peter Damm Cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.
description	<h4>Objective</h4>We aimed to evaluate cognitive function in adult offspring of women with diet-treated gestational diabetes and to study potential associations with maternal glucose values.<h4>Materials and methods</h4>In 2003-2005 cognitive function was assessed in a cohort of 18-27 year old offspring of women with diet-treated gestational diabetes mellitus (n = 153) and offspring from the background population (n = 118). The main outcome measure was global cognitive score derived from Raven's Progressive Matrices and three verbal subtests from the Weschler Adult Intelligence Scale. Maternal fasting- and 2-hour blood glucose values from the diagnostic oral glucose tolerance test were used as exposure variables.<h4>Results</h4>Offspring of women with gestational diabetes mellitus had a lower global cognitive score, than offspring from the background population (93.1 vs. 100.0, P<0.001). However, when adjusted for maternal age at delivery, parity, smoking during pregnancy, pre-pregnancy overweight, family social class, parental educational level, gender, birth weight, gestational age, perinatal complications and offspring age at follow-up, the difference was no longer statistically significant. Offspring global cognitive score decreased significantly with increasing maternal fasting glucose (β = -4.5, 95% CI -8.0 to -0.9, P = 0.01) and 2-hour glucose (β = -1.5, -2.9 to -0.2, P = 0.03) in univariate general linear models, but not when adjusted for family social class and parental educational level.<h4>Conclusions</h4>Lower cognitive test scores in adult offspring of women with diet-treated gestational diabetes were explained by well known predictors of cognitive function, but not by maternal hyperglycaemia during pregnancy. We find it reassuring that mild intrauterine hyperglycaemia does not seem to have adverse effect on offspring cognitive function.
format	article
author	Tine D Clausen Erik L Mortensen Lone Schmidt Elisabeth R Mathiesen Torben Hansen Dorte M Jensen Peter Damm
author_facet	Tine D Clausen Erik L Mortensen Lone Schmidt Elisabeth R Mathiesen Torben Hansen Dorte M Jensen Peter Damm
author_sort	Tine D Clausen
title	Cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.
title_short	Cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.
title_full	Cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.
title_fullStr	Cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.
title_full_unstemmed	Cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.
title_sort	cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e221bb24dbc844c6a817409da342808d
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Cognitive function in adult offspring of women with gestational diabetes--the role of glucose and other factors.

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