Wnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox<sup>®</sup>
Fibromyalgia (FM) is a chronic condition characterized by persistent widespread pain that negatively affects the quality of life of patients. The WNT/β-catenin signaling pathway seems to be involved in central sensitization and different pain states. The objective of this study was to investigate th...
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2021
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oai:doaj.org-article:e221d5f3e66b40a6978633ee0fce13222021-11-25T16:50:47ZWnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox<sup>®</sup>10.3390/biomedicines91116832227-9059https://doaj.org/article/e221d5f3e66b40a6978633ee0fce13222021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1683https://doaj.org/toc/2227-9059Fibromyalgia (FM) is a chronic condition characterized by persistent widespread pain that negatively affects the quality of life of patients. The WNT/β-catenin signaling pathway seems to be involved in central sensitization and different pain states. The objective of this study was to investigate the beneficial effects of a new compound called Hidrox<sup>®</sup> (HD), containing 40–50% hydroxytyrosol, in counteracting the pain associated with FM. An FM-like model was induced in rats by subcutaneous injections of reserpine (1 mg/kg) for three consecutive days. Later, HD (10 mg/kg) was administered orally to the animals for seven days. Reserpine injections induced WNT/β-catenin pathway activation, release of pro-inflammatory mediators as well as a significant increase in oxidative stress. Daily treatment with HD was able to modulate the WNT/β-catenin and Nrf2 pathways and consequently attenuate the behavioral deficits and microglia activation induced by reserpine injection. These results indicate that nutritional consumption of HD can be considered as a new therapeutic approach for human FM.Ramona D’AmicoMarika CordaroRosalba SiracusaDaniela ImpellizzeriAngela Trovato SalinaroMaria ScutoMaria Laura OntarioRoberto CreaSalvatore CuzzocreaRosanna Di PaolaRoberta FuscoVittorio CalabreseMDPI AGarticlefibromyalgiapainWNT/β-catenin pathwayNrf2 pathwayBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1683, p 1683 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
fibromyalgia pain WNT/β-catenin pathway Nrf2 pathway Biology (General) QH301-705.5 |
| spellingShingle |
fibromyalgia pain WNT/β-catenin pathway Nrf2 pathway Biology (General) QH301-705.5 Ramona D’Amico Marika Cordaro Rosalba Siracusa Daniela Impellizzeri Angela Trovato Salinaro Maria Scuto Maria Laura Ontario Roberto Crea Salvatore Cuzzocrea Rosanna Di Paola Roberta Fusco Vittorio Calabrese Wnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox<sup>®</sup> |
| description |
Fibromyalgia (FM) is a chronic condition characterized by persistent widespread pain that negatively affects the quality of life of patients. The WNT/β-catenin signaling pathway seems to be involved in central sensitization and different pain states. The objective of this study was to investigate the beneficial effects of a new compound called Hidrox<sup>®</sup> (HD), containing 40–50% hydroxytyrosol, in counteracting the pain associated with FM. An FM-like model was induced in rats by subcutaneous injections of reserpine (1 mg/kg) for three consecutive days. Later, HD (10 mg/kg) was administered orally to the animals for seven days. Reserpine injections induced WNT/β-catenin pathway activation, release of pro-inflammatory mediators as well as a significant increase in oxidative stress. Daily treatment with HD was able to modulate the WNT/β-catenin and Nrf2 pathways and consequently attenuate the behavioral deficits and microglia activation induced by reserpine injection. These results indicate that nutritional consumption of HD can be considered as a new therapeutic approach for human FM. |
| format |
article |
| author |
Ramona D’Amico Marika Cordaro Rosalba Siracusa Daniela Impellizzeri Angela Trovato Salinaro Maria Scuto Maria Laura Ontario Roberto Crea Salvatore Cuzzocrea Rosanna Di Paola Roberta Fusco Vittorio Calabrese |
| author_facet |
Ramona D’Amico Marika Cordaro Rosalba Siracusa Daniela Impellizzeri Angela Trovato Salinaro Maria Scuto Maria Laura Ontario Roberto Crea Salvatore Cuzzocrea Rosanna Di Paola Roberta Fusco Vittorio Calabrese |
| author_sort |
Ramona D’Amico |
| title |
Wnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox<sup>®</sup> |
| title_short |
Wnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox<sup>®</sup> |
| title_full |
Wnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox<sup>®</sup> |
| title_fullStr |
Wnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox<sup>®</sup> |
| title_full_unstemmed |
Wnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox<sup>®</sup> |
| title_sort |
wnt/β-catenin pathway in experimental model of fibromyalgia: role of hidrox<sup>®</sup> |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/e221d5f3e66b40a6978633ee0fce1322 |
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