Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.

Mephedrone is a drug of abuse marketed as 'bath salts". There are discrepancies concerning its long-term effects. We have investigated the neurotoxicity of mephedrone in mice following different exposition schedules. Schedule 1: four doses of 50 mg/kg. Schedule 2: four doses of 25 mg/kg. S...

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Autores principales:	José Martínez-Clemente, Raúl López-Arnau, Sonia Abad, David Pubill, Elena Escubedo, Jorge Camarasa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e223f91698534db6833aecfea11a2bbe
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spelling	oai:doaj.org-article:e223f91698534db6833aecfea11a2bbe2021-11-18T08:17:23ZDose and time-dependent selective neurotoxicity induced by mephedrone in mice.1932-620310.1371/journal.pone.0099002https://doaj.org/article/e223f91698534db6833aecfea11a2bbe2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24892744/?tool=EBIhttps://doaj.org/toc/1932-6203Mephedrone is a drug of abuse marketed as 'bath salts". There are discrepancies concerning its long-term effects. We have investigated the neurotoxicity of mephedrone in mice following different exposition schedules. Schedule 1: four doses of 50 mg/kg. Schedule 2: four doses of 25 mg/kg. Schedule 3: three daily doses of 25 mg/kg, for two consecutive days. All schedules induced, in some animals, an aggressive behavior and hyperthermia as well as a decrease in weight gain. Mephedrone (schedule 1) induced dopaminergic and serotoninergic neurotoxicity that persisted 7 days after exposition. At a lower dose (schedule 2) only a transient dopaminergic injury was found. In the weekend consumption pattern (schedule 3), mephedrone induced dopamine and serotonin transporter loss that was accompanied by a decrease in tyrosine hydroxylase and tryptophan hydroxylase 2 expression one week after exposition. Also, mephedrone induced a depressive-like behavior, as well as a reduction in striatal D2 density, suggesting higher susceptibility to addictive drugs. In cultured cortical neurons, mephedrone induced a concentration-dependent cytotoxic effect. Using repeated doses for 2 days in an elevated ambient temperature we evidenced a loss of frontal cortex dopaminergic and hippocampal serotoninergic neuronal markers that suggest injuries at nerve endings.José Martínez-ClementeRaúl López-ArnauSonia AbadDavid PubillElena EscubedoJorge CamarasaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99002 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q José Martínez-Clemente Raúl López-Arnau Sonia Abad David Pubill Elena Escubedo Jorge Camarasa Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.
description	Mephedrone is a drug of abuse marketed as 'bath salts". There are discrepancies concerning its long-term effects. We have investigated the neurotoxicity of mephedrone in mice following different exposition schedules. Schedule 1: four doses of 50 mg/kg. Schedule 2: four doses of 25 mg/kg. Schedule 3: three daily doses of 25 mg/kg, for two consecutive days. All schedules induced, in some animals, an aggressive behavior and hyperthermia as well as a decrease in weight gain. Mephedrone (schedule 1) induced dopaminergic and serotoninergic neurotoxicity that persisted 7 days after exposition. At a lower dose (schedule 2) only a transient dopaminergic injury was found. In the weekend consumption pattern (schedule 3), mephedrone induced dopamine and serotonin transporter loss that was accompanied by a decrease in tyrosine hydroxylase and tryptophan hydroxylase 2 expression one week after exposition. Also, mephedrone induced a depressive-like behavior, as well as a reduction in striatal D2 density, suggesting higher susceptibility to addictive drugs. In cultured cortical neurons, mephedrone induced a concentration-dependent cytotoxic effect. Using repeated doses for 2 days in an elevated ambient temperature we evidenced a loss of frontal cortex dopaminergic and hippocampal serotoninergic neuronal markers that suggest injuries at nerve endings.
format	article
author	José Martínez-Clemente Raúl López-Arnau Sonia Abad David Pubill Elena Escubedo Jorge Camarasa
author_facet	José Martínez-Clemente Raúl López-Arnau Sonia Abad David Pubill Elena Escubedo Jorge Camarasa
author_sort	José Martínez-Clemente
title	Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.
title_short	Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.
title_full	Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.
title_fullStr	Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.
title_full_unstemmed	Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.
title_sort	dose and time-dependent selective neurotoxicity induced by mephedrone in mice.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/e223f91698534db6833aecfea11a2bbe
work_keys_str_mv	AT josemartinezclemente doseandtimedependentselectiveneurotoxicityinducedbymephedroneinmice AT raullopezarnau doseandtimedependentselectiveneurotoxicityinducedbymephedroneinmice AT soniaabad doseandtimedependentselectiveneurotoxicityinducedbymephedroneinmice AT davidpubill doseandtimedependentselectiveneurotoxicityinducedbymephedroneinmice AT elenaescubedo doseandtimedependentselectiveneurotoxicityinducedbymephedroneinmice AT jorgecamarasa doseandtimedependentselectiveneurotoxicityinducedbymephedroneinmice
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Dose and time-dependent selective neurotoxicity induced by mephedrone in mice.

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