Associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus

Abstract Background Serum lipid abnormalities are generally considered as a major risk factor for type 2 diabetes mellitus (T2DM). However, evidence for the effect of long-term serum lipid fluctuations on future T2DM probability remains limited. Methods A total of 4475 nondiabetic participants who u...

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Autores principales:	Qian Sun, Jingchao Liu, Lei Wu, Yue Sun, Jianrong Jin, Sudan Wang, Jing Wu, Yang Jing, Hui Zhou, Chen Dong
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Type 2 diabetes mellitus Serum lipids Visit-to-visit variability Trajectory Association Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/e22880c7ef874e879ed0aad90248697d
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spelling	oai:doaj.org-article:e22880c7ef874e879ed0aad90248697d2021-11-28T12:39:02ZAssociations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus10.1186/s12944-021-01592-91476-511Xhttps://doaj.org/article/e22880c7ef874e879ed0aad90248697d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01592-9https://doaj.org/toc/1476-511XAbstract Background Serum lipid abnormalities are generally considered as a major risk factor for type 2 diabetes mellitus (T2DM). However, evidence for the effect of long-term serum lipid fluctuations on future T2DM probability remains limited. Methods A total of 4475 nondiabetic participants who underwent annual health examinations between 2010 and 2013 were followed for the subsequent 5-year risk of T2DM. The Cox proportional hazards model was performed to evaluate the associations of visit-to-visit variabilities and trajectories of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) with T2DM probability. Results During the five-year follow-up, 223 newly developed T2DM cases were identified. Compared with the “Low” TG trajectory, “Moderate” and “Moderate-High” TG trajectories were significantly associated with T2DM incidence, with adjusted hazard ratios (HRs) and 95 % confidence intervals (CIs) of 1.51 (1.12-2.03) and 2.55 (1.62-4.03), respectively. Additionally, participants in the third and fourth quartiles of TG/standard deviation (SD) were associated with increased T2DM probability when compared with those in the lowest quartile. After excluding individuals with prediabetes, participants with “Moderate-High” TG trajectory still had a 2.43-fold greater risk of T2DM compared with those with “Low” TG trajectory (95 % CI: 1.28-4.63). In addition, compared with participants in “Low” HDL-c trajectory, the future T2DM probability was significantly reduced in those with “Moderate” and “High” HDL-c trajectories, with HR (95 % CI) of 0.52 (0.37-0.72) and 0.38 (0.18-0.80), respectively. After excluding individuals with prediabetes, the “Moderate” HDL-c trajectory remained associated with decreased T2DM probability when compared with “Low” HDL-c trajectory (HR: 0.55, 95 % CI: 0.35-0.88). However, the incidence of T2DM was not associated with the long-term fluctuations of TC and LDL-c. Conclusions Long-term visit-to-visit variability of TG, and the change trajectories of TG and HDL-c were significantly associated with future T2DM probability. Moreover, these associations were not affected after excluding individuals with prediabetes.Qian SunJingchao LiuLei WuYue SunJianrong JinSudan WangJing WuYang JingHui ZhouChen DongBMCarticleType 2 diabetes mellitusSerum lipidsVisit-to-visit variabilityTrajectoryAssociationNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Type 2 diabetes mellitus Serum lipids Visit-to-visit variability Trajectory Association Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Type 2 diabetes mellitus Serum lipids Visit-to-visit variability Trajectory Association Nutritional diseases. Deficiency diseases RC620-627 Qian Sun Jingchao Liu Lei Wu Yue Sun Jianrong Jin Sudan Wang Jing Wu Yang Jing Hui Zhou Chen Dong Associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus
description	Abstract Background Serum lipid abnormalities are generally considered as a major risk factor for type 2 diabetes mellitus (T2DM). However, evidence for the effect of long-term serum lipid fluctuations on future T2DM probability remains limited. Methods A total of 4475 nondiabetic participants who underwent annual health examinations between 2010 and 2013 were followed for the subsequent 5-year risk of T2DM. The Cox proportional hazards model was performed to evaluate the associations of visit-to-visit variabilities and trajectories of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) with T2DM probability. Results During the five-year follow-up, 223 newly developed T2DM cases were identified. Compared with the “Low” TG trajectory, “Moderate” and “Moderate-High” TG trajectories were significantly associated with T2DM incidence, with adjusted hazard ratios (HRs) and 95 % confidence intervals (CIs) of 1.51 (1.12-2.03) and 2.55 (1.62-4.03), respectively. Additionally, participants in the third and fourth quartiles of TG/standard deviation (SD) were associated with increased T2DM probability when compared with those in the lowest quartile. After excluding individuals with prediabetes, participants with “Moderate-High” TG trajectory still had a 2.43-fold greater risk of T2DM compared with those with “Low” TG trajectory (95 % CI: 1.28-4.63). In addition, compared with participants in “Low” HDL-c trajectory, the future T2DM probability was significantly reduced in those with “Moderate” and “High” HDL-c trajectories, with HR (95 % CI) of 0.52 (0.37-0.72) and 0.38 (0.18-0.80), respectively. After excluding individuals with prediabetes, the “Moderate” HDL-c trajectory remained associated with decreased T2DM probability when compared with “Low” HDL-c trajectory (HR: 0.55, 95 % CI: 0.35-0.88). However, the incidence of T2DM was not associated with the long-term fluctuations of TC and LDL-c. Conclusions Long-term visit-to-visit variability of TG, and the change trajectories of TG and HDL-c were significantly associated with future T2DM probability. Moreover, these associations were not affected after excluding individuals with prediabetes.
format	article
author	Qian Sun Jingchao Liu Lei Wu Yue Sun Jianrong Jin Sudan Wang Jing Wu Yang Jing Hui Zhou Chen Dong
author_facet	Qian Sun Jingchao Liu Lei Wu Yue Sun Jianrong Jin Sudan Wang Jing Wu Yang Jing Hui Zhou Chen Dong
author_sort	Qian Sun
title	Associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus
title_short	Associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus
title_full	Associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus
title_fullStr	Associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus
title_full_unstemmed	Associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus
title_sort	associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e22880c7ef874e879ed0aad90248697d
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Associations of visit-to-visit variabilities and trajectories of serum lipids with the future probability of type 2 diabetes mellitus

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