One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization

Abstract We developed an efficient synthesis of aza-chromones from 3-iodo-4-(1H)-pyridones and terminal acetylenes via a cascade carbonylation-Sonogashira-cyclization reaction. By controlling the use of bases, both 6-aza-chromones 5 and 3-(4-oxo-1,4-dihydroquinoline-3-carbonyl)-4H-pyrano[3,2-c]quino...

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Autores principales:	Gang Cheng, Yingbei Qi, Xiaoqian Zhou, Rong Sheng, Yong-Zhou Hu, Youhong Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e2290e184752452ab45873be86b563b7
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spelling	oai:doaj.org-article:e2290e184752452ab45873be86b563b72021-12-02T11:41:00ZOne-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization10.1038/s41598-017-04693-72045-2322https://doaj.org/article/e2290e184752452ab45873be86b563b72017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04693-7https://doaj.org/toc/2045-2322Abstract We developed an efficient synthesis of aza-chromones from 3-iodo-4-(1H)-pyridones and terminal acetylenes via a cascade carbonylation-Sonogashira-cyclization reaction. By controlling the use of bases, both 6-aza-chromones 5 and 3-(4-oxo-1,4-dihydroquinoline-3-carbonyl)-4H-pyrano[3,2-c]quinolin-4-ones 6 could be selectively obtained in moderate to good yields.Gang ChengYingbei QiXiaoqian ZhouRong ShengYong-Zhou HuYouhong HuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gang Cheng Yingbei Qi Xiaoqian Zhou Rong Sheng Yong-Zhou Hu Youhong Hu One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization
description	Abstract We developed an efficient synthesis of aza-chromones from 3-iodo-4-(1H)-pyridones and terminal acetylenes via a cascade carbonylation-Sonogashira-cyclization reaction. By controlling the use of bases, both 6-aza-chromones 5 and 3-(4-oxo-1,4-dihydroquinoline-3-carbonyl)-4H-pyrano[3,2-c]quinolin-4-ones 6 could be selectively obtained in moderate to good yields.
format	article
author	Gang Cheng Yingbei Qi Xiaoqian Zhou Rong Sheng Yong-Zhou Hu Youhong Hu
author_facet	Gang Cheng Yingbei Qi Xiaoqian Zhou Rong Sheng Yong-Zhou Hu Youhong Hu
author_sort	Gang Cheng
title	One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization
title_short	One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization
title_full	One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization
title_fullStr	One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization
title_full_unstemmed	One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization
title_sort	one-pot synthesis of 6-aza-chromone derivatives through cascade carbonylation-sonogashira-cyclization
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e2290e184752452ab45873be86b563b7
work_keys_str_mv	AT gangcheng onepotsynthesisof6azachromonederivativesthroughcascadecarbonylationsonogashiracyclization AT yingbeiqi onepotsynthesisof6azachromonederivativesthroughcascadecarbonylationsonogashiracyclization AT xiaoqianzhou onepotsynthesisof6azachromonederivativesthroughcascadecarbonylationsonogashiracyclization AT rongsheng onepotsynthesisof6azachromonederivativesthroughcascadecarbonylationsonogashiracyclization AT yongzhouhu onepotsynthesisof6azachromonederivativesthroughcascadecarbonylationsonogashiracyclization AT youhonghu onepotsynthesisof6azachromonederivativesthroughcascadecarbonylationsonogashiracyclization
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One-pot Synthesis of 6-Aza-chromone Derivatives Through Cascade Carbonylation-Sonogashira-Cyclization

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