Targeting interleukin-6 for noninfectious uveitis

Targeting interleukin-6 for noninfectious uveitis

Phoebe Lin Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA Abstract: Interleukin-6 (IL-6) is a pleiotropic cytokine implicated in the pathogenesis of many immune-mediated disorders including several types of non-infectious uveitis. These uveitic conditions include Vogt-K...

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Autor principal: Lin P
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/e22a1bfb83c14df7a1bf5c4eafc822d3
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spelling oai:doaj.org-article:e22a1bfb83c14df7a1bf5c4eafc822d32021-12-02T00:59:13ZTargeting interleukin-6 for noninfectious uveitis1177-5483https://doaj.org/article/e22a1bfb83c14df7a1bf5c4eafc822d32015-09-01T00:00:00Zhttps://www.dovepress.com/targeting-interleukin-6-for-noninfectious-uveitis-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Phoebe Lin Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA Abstract: Interleukin-6 (IL-6) is a pleiotropic cytokine implicated in the pathogenesis of many immune-mediated disorders including several types of non-infectious uveitis. These uveitic conditions include Vogt-Koyanagi-Harada syndrome, uveitis associated with Behçet disease, and sarcoidosis. This review summarizes the role of IL-6 in immunity, highlighting its effect on Th17, Th1, and plasmablast differentiation. It reviews the downstream mediators activated in the process of IL-6 binding to its receptor complex. This review also summarizes the biologics targeting either IL-6 or the IL-6 receptor, including tocilizumab, sarilumab, sirukumab, olokizumab, clazakizumab, and siltuximab. The target, dosage, potential side effects, and potential uses of these biologics are summarized in this article based on the existing literature. In summary, anti-IL-6 therapy for non-infectious uveitis shows promise in terms of efficacy and side effect profile. Keywords: interleukin-6, T lymphocyte, B lymphocyte, autoimmunity, uveitisLin PDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1697-1702 (2015)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Lin P
Targeting interleukin-6 for noninfectious uveitis
description Phoebe Lin Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA Abstract: Interleukin-6 (IL-6) is a pleiotropic cytokine implicated in the pathogenesis of many immune-mediated disorders including several types of non-infectious uveitis. These uveitic conditions include Vogt-Koyanagi-Harada syndrome, uveitis associated with Behçet disease, and sarcoidosis. This review summarizes the role of IL-6 in immunity, highlighting its effect on Th17, Th1, and plasmablast differentiation. It reviews the downstream mediators activated in the process of IL-6 binding to its receptor complex. This review also summarizes the biologics targeting either IL-6 or the IL-6 receptor, including tocilizumab, sarilumab, sirukumab, olokizumab, clazakizumab, and siltuximab. The target, dosage, potential side effects, and potential uses of these biologics are summarized in this article based on the existing literature. In summary, anti-IL-6 therapy for non-infectious uveitis shows promise in terms of efficacy and side effect profile. Keywords: interleukin-6, T lymphocyte, B lymphocyte, autoimmunity, uveitis
format article
author Lin P
author_facet Lin P
author_sort Lin P
title Targeting interleukin-6 for noninfectious uveitis
title_short Targeting interleukin-6 for noninfectious uveitis
title_full Targeting interleukin-6 for noninfectious uveitis
title_fullStr Targeting interleukin-6 for noninfectious uveitis
title_full_unstemmed Targeting interleukin-6 for noninfectious uveitis
title_sort targeting interleukin-6 for noninfectious uveitis
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/e22a1bfb83c14df7a1bf5c4eafc822d3
work_keys_str_mv AT linp targetinginterleukin6fornoninfectiousuveitis
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