Reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: a 12-month intervention

Hajime Haimoto,1 Tae Sasakabe,2 Hiroyuki Umegaki,3 Kenji Wakai41Department of Internal Medicine, Haimoto Clinic, Kasugai, 2Department of Clinical Nutrition, Haimoto Clinic, Kasugai, 3Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, 4Department of Preventive Medicine,...

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Autores principales:	Haimoto H, Sasakabe T, Umegaki H, Wakai K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/e22a34abaf204ba4856686e5ceccc2b2
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spelling	oai:doaj.org-article:e22a34abaf204ba4856686e5ceccc2b22021-12-02T02:05:47ZReduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: a 12-month intervention1178-7007https://doaj.org/article/e22a34abaf204ba4856686e5ceccc2b22012-08-01T00:00:00Zhttp://www.dovepress.com/reduction-in-urinary-albumin-excretion-with-a-moderate-low-carbohydrat-a10671https://doaj.org/toc/1178-7007Hajime Haimoto,1 Tae Sasakabe,2 Hiroyuki Umegaki,3 Kenji Wakai41Department of Internal Medicine, Haimoto Clinic, Kasugai, 2Department of Clinical Nutrition, Haimoto Clinic, Kasugai, 3Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, 4Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanIntroduction: Urinary albumin excretion (UAE) is a marker of the early phase of diabetic nephropathy. Although a low-carbohydrate diet (LCD) has been shown to effectively improve glycemic control in patients with type 2 diabetes (T2DM), its effects on UAE remain unknown.Patients and methods: A total of 124 patients (mean age &plusmn; standard deviation, 61.6 &plusmn; 9.2 years) with T2DM were instructed to consume a moderate LCD (1734 &plusmn; 416 kcal/d; % carbohydrate:fat:protein = 38:37:19) for 12 months. We measured the levels of UAE, hemoglobin A1c, fasting plasma glucose, fasting serum insulin (IRI), and the serum lipid profiles in the patients and recorded their dosages of antidiabetic drugs during this 12-month period.Results: Of the 124 patients, 68 were normoalbuminuric, 50 were microalbuminuric, and six were macroalbuminuric at baseline. The patients had relatively good compliance with the moderate LCD diet. After 12 months, the mean levels of hemoglobin A1c, fasting plasma glucose, IRI, homeostasis model assessment-estimated insulin resistance, and the body mass index of all participants significantly decreased (P = 0.003 for IRI and P &lt; 0.001 for the other parameters). Among the microalbuminuric patients (n = 50), remission to normoalbuminuria was frequently achieved (52%) and the geometric mean UAE significantly decreased by 53% (95% confidence interval: 43, 62) over 12 months (P &lt; 0.001). After patients taking an angiotensin 2 receptor blocker were excluded, the UAE significantly decreased by 41% (n = 26, 95% confidence interval: 25, 54; P &lt; 0.001). Moreover, the reduction in UAE was significantly and positively correlated with a reduction in homeostasis model assessment-estimated insulin resistance levels (rs = 0.308; P = 0.031).Conclusion: A moderate LCD (38% carbohydrate diet) achieved a remarkable reduction in UAE over 12 months in microalbuminuric patients with T2DM.Keywords: glycemic control, microalbuminuria, angiotensin 2 receptor blockers, insulin resistanceHaimoto HSasakabe TUmegaki HWakai KDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2012, Iss default, Pp 283-291 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Haimoto H Sasakabe T Umegaki H Wakai K Reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: a 12-month intervention
description	Hajime Haimoto,1 Tae Sasakabe,2 Hiroyuki Umegaki,3 Kenji Wakai41Department of Internal Medicine, Haimoto Clinic, Kasugai, 2Department of Clinical Nutrition, Haimoto Clinic, Kasugai, 3Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, 4Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, JapanIntroduction: Urinary albumin excretion (UAE) is a marker of the early phase of diabetic nephropathy. Although a low-carbohydrate diet (LCD) has been shown to effectively improve glycemic control in patients with type 2 diabetes (T2DM), its effects on UAE remain unknown.Patients and methods: A total of 124 patients (mean age &plusmn; standard deviation, 61.6 &plusmn; 9.2 years) with T2DM were instructed to consume a moderate LCD (1734 &plusmn; 416 kcal/d; % carbohydrate:fat:protein = 38:37:19) for 12 months. We measured the levels of UAE, hemoglobin A1c, fasting plasma glucose, fasting serum insulin (IRI), and the serum lipid profiles in the patients and recorded their dosages of antidiabetic drugs during this 12-month period.Results: Of the 124 patients, 68 were normoalbuminuric, 50 were microalbuminuric, and six were macroalbuminuric at baseline. The patients had relatively good compliance with the moderate LCD diet. After 12 months, the mean levels of hemoglobin A1c, fasting plasma glucose, IRI, homeostasis model assessment-estimated insulin resistance, and the body mass index of all participants significantly decreased (P = 0.003 for IRI and P &lt; 0.001 for the other parameters). Among the microalbuminuric patients (n = 50), remission to normoalbuminuria was frequently achieved (52%) and the geometric mean UAE significantly decreased by 53% (95% confidence interval: 43, 62) over 12 months (P &lt; 0.001). After patients taking an angiotensin 2 receptor blocker were excluded, the UAE significantly decreased by 41% (n = 26, 95% confidence interval: 25, 54; P &lt; 0.001). Moreover, the reduction in UAE was significantly and positively correlated with a reduction in homeostasis model assessment-estimated insulin resistance levels (rs = 0.308; P = 0.031).Conclusion: A moderate LCD (38% carbohydrate diet) achieved a remarkable reduction in UAE over 12 months in microalbuminuric patients with T2DM.Keywords: glycemic control, microalbuminuria, angiotensin 2 receptor blockers, insulin resistance
format	article
author	Haimoto H Sasakabe T Umegaki H Wakai K
author_facet	Haimoto H Sasakabe T Umegaki H Wakai K
author_sort	Haimoto H
title	Reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: a 12-month intervention
title_short	Reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: a 12-month intervention
title_full	Reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: a 12-month intervention
title_fullStr	Reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: a 12-month intervention
title_full_unstemmed	Reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: a 12-month intervention
title_sort	reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: a 12-month intervention
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/e22a34abaf204ba4856686e5ceccc2b2
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Reduction in urinary albumin excretion with a moderate low-carbohydrate diet in patients with type 2 diabetes: a 12-month intervention

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