Hyperprolactinaemia in male infertility: Clinical case scenarios

Objective: To explore the evaluation, treatment and impact of hyperprolactinaemia on male infertility and testicular function, as hyperprolactinaemia is commonly detected during the evaluation of infertile men. Methods: A literature search was performed using MEDLINE/PubMed according to the Preferre...

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Autores principales:	Zeinab Dabbous, Stephen L Atkin
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/e22c9d3ff7594cc6a89ef007d3f9003d
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spelling	oai:doaj.org-article:e22c9d3ff7594cc6a89ef007d3f9003d2021-12-02T12:02:04ZHyperprolactinaemia in male infertility: Clinical case scenarios2090-598X10.1016/j.aju.2017.10.002https://doaj.org/article/e22c9d3ff7594cc6a89ef007d3f9003d2018-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17301080https://doaj.org/toc/2090-598XObjective: To explore the evaluation, treatment and impact of hyperprolactinaemia on male infertility and testicular function, as hyperprolactinaemia is commonly detected during the evaluation of infertile men. Methods: A literature search was performed using MEDLINE/PubMed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify all studies exploring hyperprolactinaemia in male infertility. Results: Elevated levels of serum prolactin have a detrimental effect on male reproduction through inhibition of the pulsatile release of gonadotrophins from the anterior pituitary gland, and a direct effect on spermatogenesis. Treatment of confirmed hyperprolactinaemia with dopamine agonists leads to significant improvements in both semen parameters and hormone levels. Conclusion: Hyperprolactinaemia, both directly and indirectly, has a negative effect on sperm production, and its detection and management in men seeking fertility is mandatory. Keywords: Prolactin, Male infertility, Dopamine agonists, Testosterone, Pituitary adenomaZeinab DabbousStephen L AtkinTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss 1, Pp 44-52 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Zeinab Dabbous Stephen L Atkin Hyperprolactinaemia in male infertility: Clinical case scenarios
description	Objective: To explore the evaluation, treatment and impact of hyperprolactinaemia on male infertility and testicular function, as hyperprolactinaemia is commonly detected during the evaluation of infertile men. Methods: A literature search was performed using MEDLINE/PubMed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify all studies exploring hyperprolactinaemia in male infertility. Results: Elevated levels of serum prolactin have a detrimental effect on male reproduction through inhibition of the pulsatile release of gonadotrophins from the anterior pituitary gland, and a direct effect on spermatogenesis. Treatment of confirmed hyperprolactinaemia with dopamine agonists leads to significant improvements in both semen parameters and hormone levels. Conclusion: Hyperprolactinaemia, both directly and indirectly, has a negative effect on sperm production, and its detection and management in men seeking fertility is mandatory. Keywords: Prolactin, Male infertility, Dopamine agonists, Testosterone, Pituitary adenoma
format	article
author	Zeinab Dabbous Stephen L Atkin
author_facet	Zeinab Dabbous Stephen L Atkin
author_sort	Zeinab Dabbous
title	Hyperprolactinaemia in male infertility: Clinical case scenarios
title_short	Hyperprolactinaemia in male infertility: Clinical case scenarios
title_full	Hyperprolactinaemia in male infertility: Clinical case scenarios
title_fullStr	Hyperprolactinaemia in male infertility: Clinical case scenarios
title_full_unstemmed	Hyperprolactinaemia in male infertility: Clinical case scenarios
title_sort	hyperprolactinaemia in male infertility: clinical case scenarios
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/e22c9d3ff7594cc6a89ef007d3f9003d
work_keys_str_mv	AT zeinabdabbous hyperprolactinaemiainmaleinfertilityclinicalcasescenarios AT stephenlatkin hyperprolactinaemiainmaleinfertilityclinicalcasescenarios
_version_	1718394779980529664

Hyperprolactinaemia in male infertility: Clinical case scenarios

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