Lorcaserin for weight management

James R Taylor, Eric Dietrich, Jason PowellUniversity of Florida College of Pharmacy, Department of Pharmacotherapy and Translational Research, Gainesville, FL, USAAbstract: Type 2 diabetes and obesity commonly occur together. Obesity contributes to insulin resistance, a main cause of type 2 diabete...

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Autores principales: Taylor JR, Dietrich E, Powell J
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Lenguaje:EN
Publicado: Dove Medical Press 2013
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Acceso en línea:https://doaj.org/article/e230bb5d652f4158bc3432b2157a6039
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spelling oai:doaj.org-article:e230bb5d652f4158bc3432b2157a60392021-12-02T07:11:50ZLorcaserin for weight management1178-7007https://doaj.org/article/e230bb5d652f4158bc3432b2157a60392013-06-01T00:00:00Zhttp://www.dovepress.com/lorcaserin-for-weight-management-a13331https://doaj.org/toc/1178-7007James R Taylor, Eric Dietrich, Jason PowellUniversity of Florida College of Pharmacy, Department of Pharmacotherapy and Translational Research, Gainesville, FL, USAAbstract: Type 2 diabetes and obesity commonly occur together. Obesity contributes to insulin resistance, a main cause of type 2 diabetes. Modest weight loss reduces glucose, lipids, blood pressure, need for medications, and cardiovascular risk. A number of approaches can be used to achieve weight loss, including lifestyle modification, surgery, and medication. Lorcaserin, a novel antiobesity agent, affects central serotonin subtype 2A receptors, resulting in decreased food intake and increased satiety. It has been studied in obese patients with type 2 diabetes and results in an approximately 5.5 kg weight loss, on average, when used for one year. Headache, back pain, nasopharyngitis, and nausea were the most common adverse effects noted with lorcaserin. Hypoglycemia was more common in the lorcaserin groups in the clinical trials, but none of the episodes were categorized as severe. Based on the results of these studies, lorcaserin was approved at a dose of 10 mg twice daily in patients with a body mass index ≥30 kg/m2 or ≥27 kg/m2 with at least one weight-related comorbidity, such as hypertension, type 2 diabetes mellitus, or dyslipidemia, in addition to a reduced calorie diet and increased physical activity. Lorcaserin is effective for weight loss in obese patients with and without type 2 diabetes, although its specific role in the management of obesity is unclear at this time. This paper reviews the clinical trials of lorcaserin, its use from the patient perspective, and its potential role in the treatment of obesity.Keywords: lorcaserin, obesity, diabetesTaylor JRDietrich EPowell JDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2013, Iss default, Pp 209-216 (2013)
institution DOAJ
collection DOAJ
language EN
topic Specialties of internal medicine
RC581-951
spellingShingle Specialties of internal medicine
RC581-951
Taylor JR
Dietrich E
Powell J
Lorcaserin for weight management
description James R Taylor, Eric Dietrich, Jason PowellUniversity of Florida College of Pharmacy, Department of Pharmacotherapy and Translational Research, Gainesville, FL, USAAbstract: Type 2 diabetes and obesity commonly occur together. Obesity contributes to insulin resistance, a main cause of type 2 diabetes. Modest weight loss reduces glucose, lipids, blood pressure, need for medications, and cardiovascular risk. A number of approaches can be used to achieve weight loss, including lifestyle modification, surgery, and medication. Lorcaserin, a novel antiobesity agent, affects central serotonin subtype 2A receptors, resulting in decreased food intake and increased satiety. It has been studied in obese patients with type 2 diabetes and results in an approximately 5.5 kg weight loss, on average, when used for one year. Headache, back pain, nasopharyngitis, and nausea were the most common adverse effects noted with lorcaserin. Hypoglycemia was more common in the lorcaserin groups in the clinical trials, but none of the episodes were categorized as severe. Based on the results of these studies, lorcaserin was approved at a dose of 10 mg twice daily in patients with a body mass index ≥30 kg/m2 or ≥27 kg/m2 with at least one weight-related comorbidity, such as hypertension, type 2 diabetes mellitus, or dyslipidemia, in addition to a reduced calorie diet and increased physical activity. Lorcaserin is effective for weight loss in obese patients with and without type 2 diabetes, although its specific role in the management of obesity is unclear at this time. This paper reviews the clinical trials of lorcaserin, its use from the patient perspective, and its potential role in the treatment of obesity.Keywords: lorcaserin, obesity, diabetes
format article
author Taylor JR
Dietrich E
Powell J
author_facet Taylor JR
Dietrich E
Powell J
author_sort Taylor JR
title Lorcaserin for weight management
title_short Lorcaserin for weight management
title_full Lorcaserin for weight management
title_fullStr Lorcaserin for weight management
title_full_unstemmed Lorcaserin for weight management
title_sort lorcaserin for weight management
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/e230bb5d652f4158bc3432b2157a6039
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