Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and COMT gene

Xiaoli Tang,1 Jun Jin,1 Yi Tang,1 Jinbo Cao,1 Junjie Huang2 1Department of Radiology, Shekou People’s Hospital, Shenzhen, 2Department of Medicine, Shenzhen University, Guangdong, People’s Republic of China Background: Blood–oxygen-level dependent functional magnetic r...

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Autores principales:	Tang X, Jin J, Tang Y, Cao J, Huang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	fMRI BOLD COMT polymorphism schizophrenia violence Chinese Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e230f422e7034756ba8d53aed927dde8
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spelling	oai:doaj.org-article:e230f422e7034756ba8d53aed927dde82021-12-02T06:23:33ZRisk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and COMT gene1178-2021https://doaj.org/article/e230f422e7034756ba8d53aed927dde82017-02-01T00:00:00Zhttps://www.dovepress.com/risk-assessment-of-aggressive-behavior-in-chinese-patients-with-schizo-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiaoli Tang,1 Jun Jin,1 Yi Tang,1 Jinbo Cao,1 Junjie Huang2 1Department of Radiology, Shekou People’s Hospital, Shenzhen, 2Department of Medicine, Shenzhen University, Guangdong, People’s Republic of China Background: Blood–oxygen-level dependent functional magnetic resonance imaging (BOLD-fMRI) maps cerebral activity by the hemodynamic response. Catechol-O-methyltransferase (COMT) gene is involved in the metabolism of dopamine. It is reported that both of these can be used to assess the aggression risk in patients with schizophrenia. However, these methods to assess the aggression risk patients with schizophrenia have not been established in China. Therefore, we deliver here a systematic review and meta-analysis based on the studies dealing with Chinese patients. Method: Nine fMRI studies and 12 gene studies were included. The data of each study were extracted and summarized. Odds ratios with 95% confidence intervals were estimated on allele, dominant, and recessive models. Publication bias was evaluated by Begg’s funnel plot. Results: Positive BOLD-fMRI values in the lower central neural system (CNS) and negative values in the high-level CNS were observed in the patients with aggression risk. A strong association was derived from the recessive gene model of COMT polymorphism rs4680 and risk in aggression behavior (odds ratio =2.10). No significant publication bias was identified. Conclusion: Aggression behavior in patients with schizophrenia can be indicated by positive BOLD-fMRI values in the lower CNS and negative values in the high-level CNS and by a recessive gene model in COMT polymorphism rs4680. A combined test of fMRI and COMT gene could increase the predictive value. Keywords: aggression, schizophrenia, Chinese, fMRI, COMT, meta-analysisTang XJin JTang YCao JHuang JDove Medical PressarticlefMRIBOLDCOMTpolymorphismschizophreniaviolenceChineseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 387-395 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	fMRI BOLD COMT polymorphism schizophrenia violence Chinese Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	fMRI BOLD COMT polymorphism schizophrenia violence Chinese Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Tang X Jin J Tang Y Cao J Huang J Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and COMT gene
description	Xiaoli Tang,1 Jun Jin,1 Yi Tang,1 Jinbo Cao,1 Junjie Huang2 1Department of Radiology, Shekou People’s Hospital, Shenzhen, 2Department of Medicine, Shenzhen University, Guangdong, People’s Republic of China Background: Blood–oxygen-level dependent functional magnetic resonance imaging (BOLD-fMRI) maps cerebral activity by the hemodynamic response. Catechol-O-methyltransferase (COMT) gene is involved in the metabolism of dopamine. It is reported that both of these can be used to assess the aggression risk in patients with schizophrenia. However, these methods to assess the aggression risk patients with schizophrenia have not been established in China. Therefore, we deliver here a systematic review and meta-analysis based on the studies dealing with Chinese patients. Method: Nine fMRI studies and 12 gene studies were included. The data of each study were extracted and summarized. Odds ratios with 95% confidence intervals were estimated on allele, dominant, and recessive models. Publication bias was evaluated by Begg’s funnel plot. Results: Positive BOLD-fMRI values in the lower central neural system (CNS) and negative values in the high-level CNS were observed in the patients with aggression risk. A strong association was derived from the recessive gene model of COMT polymorphism rs4680 and risk in aggression behavior (odds ratio =2.10). No significant publication bias was identified. Conclusion: Aggression behavior in patients with schizophrenia can be indicated by positive BOLD-fMRI values in the lower CNS and negative values in the high-level CNS and by a recessive gene model in COMT polymorphism rs4680. A combined test of fMRI and COMT gene could increase the predictive value. Keywords: aggression, schizophrenia, Chinese, fMRI, COMT, meta-analysis
format	article
author	Tang X Jin J Tang Y Cao J Huang J
author_facet	Tang X Jin J Tang Y Cao J Huang J
author_sort	Tang X
title	Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and COMT gene
title_short	Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and COMT gene
title_full	Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and COMT gene
title_fullStr	Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and COMT gene
title_full_unstemmed	Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and COMT gene
title_sort	risk assessment of aggressive behavior in chinese patients with schizophrenia by fmri and comt gene
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e230f422e7034756ba8d53aed927dde8
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_version_	1718399965648125952

Risk assessment of aggressive behavior in Chinese patients with schizophrenia by fMRI and COMT gene

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