Stem cells: a model for screening, discovery and development of drugs

Satish Srinivas Kitambi1, Gayathri Chandrasekar21Department of Medical Biochemistry and Biophysics; 2Department of Biosciences, Karolinska Institutet, Stockholm, SwedenAbstract: The identification of normal and cancerous stem cells and the recent advances made in isolation and culture of stem cells...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kitambi SS, Chandrasekar G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/e231022bb7234f7d91f9243d39cdde78
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e231022bb7234f7d91f9243d39cdde78
record_format	dspace
spelling	oai:doaj.org-article:e231022bb7234f7d91f9243d39cdde782021-12-02T06:23:33ZStem cells: a model for screening, discovery and development of drugs1178-6957https://doaj.org/article/e231022bb7234f7d91f9243d39cdde782011-09-01T00:00:00Zhttp://www.dovepress.com/stem-cells-a-model-for-screening-discovery-and-development-of-drugs-a8362https://doaj.org/toc/1178-6957Satish Srinivas Kitambi1, Gayathri Chandrasekar21Department of Medical Biochemistry and Biophysics; 2Department of Biosciences, Karolinska Institutet, Stockholm, SwedenAbstract: The identification of normal and cancerous stem cells and the recent advances made in isolation and culture of stem cells have rapidly gained attention in the field of drug discovery and regenerative medicine. The prospect of performing screens aimed at proliferation, directed differentiation, and toxicity and efficacy studies using stem cells offers a reliable platform for the drug discovery process. Advances made in the generation of induced pluripotent stem cells from normal or diseased tissue serves as a platform to perform drug screens aimed at developing cell-based therapies against conditions like Parkinson&#39;s disease and diabetes. This review discusses the application of stem cells and cancer stem cells in drug screening and their role in complementing, reducing, and replacing animal testing. In addition to this, target identification and major advances in the field of personalized medicine using induced pluripotent cells are also discussed.Keywords: therapeutics, stem cells, cancer stem cells, screening models, drug development, high throughput screeningKitambi SSChandrasekar GDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2011, Iss default, Pp 51-59 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Kitambi SS Chandrasekar G Stem cells: a model for screening, discovery and development of drugs
description	Satish Srinivas Kitambi1, Gayathri Chandrasekar21Department of Medical Biochemistry and Biophysics; 2Department of Biosciences, Karolinska Institutet, Stockholm, SwedenAbstract: The identification of normal and cancerous stem cells and the recent advances made in isolation and culture of stem cells have rapidly gained attention in the field of drug discovery and regenerative medicine. The prospect of performing screens aimed at proliferation, directed differentiation, and toxicity and efficacy studies using stem cells offers a reliable platform for the drug discovery process. Advances made in the generation of induced pluripotent stem cells from normal or diseased tissue serves as a platform to perform drug screens aimed at developing cell-based therapies against conditions like Parkinson&#39;s disease and diabetes. This review discusses the application of stem cells and cancer stem cells in drug screening and their role in complementing, reducing, and replacing animal testing. In addition to this, target identification and major advances in the field of personalized medicine using induced pluripotent cells are also discussed.Keywords: therapeutics, stem cells, cancer stem cells, screening models, drug development, high throughput screening
format	article
author	Kitambi SS Chandrasekar G
author_facet	Kitambi SS Chandrasekar G
author_sort	Kitambi SS
title	Stem cells: a model for screening, discovery and development of drugs
title_short	Stem cells: a model for screening, discovery and development of drugs
title_full	Stem cells: a model for screening, discovery and development of drugs
title_fullStr	Stem cells: a model for screening, discovery and development of drugs
title_full_unstemmed	Stem cells: a model for screening, discovery and development of drugs
title_sort	stem cells: a model for screening, discovery and development of drugs
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/e231022bb7234f7d91f9243d39cdde78
work_keys_str_mv	AT kitambiss stemcellsamodelforscreeningdiscoveryanddevelopmentofdrugs AT chandrasekarg stemcellsamodelforscreeningdiscoveryanddevelopmentofdrugs
_version_	1718399965853646848

Stem cells: a model for screening, discovery and development of drugs

Ejemplares similares