The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits

The report of bradycardia caused by propofol is increasing. In the experiment, we investigated the chronotropic function of propofol and the underlying mechanism. Rabbits of both sexes were randomly divided into 4 groups: propofol 5 mg/kg group, 10 mg/kg group, 15 mg/kg group, and sham group. Heart...

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Autores principales:	Wenjie Cheng, Xiaohua Sun, Yanfang Liu, Shiqi Han, Wanlu Ren
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine (General) R5-920 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/e233f401d1ce45288f0cda89ff246f08
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spelling	oai:doaj.org-article:e233f401d1ce45288f0cda89ff246f082021-11-29T00:56:15ZThe Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits2040-230910.1155/2021/5222745https://doaj.org/article/e233f401d1ce45288f0cda89ff246f082021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5222745https://doaj.org/toc/2040-2309The report of bradycardia caused by propofol is increasing. In the experiment, we investigated the chronotropic function of propofol and the underlying mechanism. Rabbits of both sexes were randomly divided into 4 groups: propofol 5 mg/kg group, 10 mg/kg group, 15 mg/kg group, and sham group. Heart rate and frequency of vagal efferent discharge were recorded before the injection and 0, 0.5, 1, 2, and 10 min after the injection through intravenous mode. Then, their hearts were removed, and sinoatrial nodes were dissected. The action potentials of the sinus node pacemaker cells were recorded by the intracellular glass microelectrode technique, and the sinoatrial (SA) node was exposed to propofol 1, 3, 5, and 10 µM respectively. The action potentials were recorded after the sinoatrial nodes were exposed to each concentration of propofol for 15 min. Our results show that the heart rate significantly decreased, and the vagal efferent discharge was significantly increased at 0, 0.5, 1, and 2 min after the injection, respectively. Besides, as the dose increases, the magnitude of change shows a dose-dependent manner. Propofol exerts a negative chronotropic action on sinoatrial node pacemaker cells. The drug significantly decreased APA, VDD, RPF, and prolonged APD90 in a concentration-dependent manner. These effects may be the main mechanism of propofol-induced bradycardia in clinical study.Wenjie ChengXiaohua SunYanfang LiuShiqi HanWanlu RenHindawi LimitedarticleMedicine (General)R5-920Medical technologyR855-855.5ENJournal of Healthcare Engineering, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920 Medical technology R855-855.5
spellingShingle	Medicine (General) R5-920 Medical technology R855-855.5 Wenjie Cheng Xiaohua Sun Yanfang Liu Shiqi Han Wanlu Ren The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits
description	The report of bradycardia caused by propofol is increasing. In the experiment, we investigated the chronotropic function of propofol and the underlying mechanism. Rabbits of both sexes were randomly divided into 4 groups: propofol 5 mg/kg group, 10 mg/kg group, 15 mg/kg group, and sham group. Heart rate and frequency of vagal efferent discharge were recorded before the injection and 0, 0.5, 1, 2, and 10 min after the injection through intravenous mode. Then, their hearts were removed, and sinoatrial nodes were dissected. The action potentials of the sinus node pacemaker cells were recorded by the intracellular glass microelectrode technique, and the sinoatrial (SA) node was exposed to propofol 1, 3, 5, and 10 µM respectively. The action potentials were recorded after the sinoatrial nodes were exposed to each concentration of propofol for 15 min. Our results show that the heart rate significantly decreased, and the vagal efferent discharge was significantly increased at 0, 0.5, 1, and 2 min after the injection, respectively. Besides, as the dose increases, the magnitude of change shows a dose-dependent manner. Propofol exerts a negative chronotropic action on sinoatrial node pacemaker cells. The drug significantly decreased APA, VDD, RPF, and prolonged APD90 in a concentration-dependent manner. These effects may be the main mechanism of propofol-induced bradycardia in clinical study.
format	article
author	Wenjie Cheng Xiaohua Sun Yanfang Liu Shiqi Han Wanlu Ren
author_facet	Wenjie Cheng Xiaohua Sun Yanfang Liu Shiqi Han Wanlu Ren
author_sort	Wenjie Cheng
title	The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits
title_short	The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits
title_full	The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits
title_fullStr	The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits
title_full_unstemmed	The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits
title_sort	chronotropic function of propofol and the underlying mechanism in rabbits
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/e233f401d1ce45288f0cda89ff246f08
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The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits

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