Folding of a bacterial integral outer membrane protein is initiated in the periplasm

The Bam complex promotes the insertion of β-barrel proteins (such as UpaG, a trimeric autotransporter adhesin) into the bacterial outer membrane. Here, Sikdar et al. show that UpaG β-barrel segments fold into a trimeric structure in the periplasm before they interact with the Bam complex.

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Autores principales:	Rakesh Sikdar, Janine H. Peterson, D. Eric Anderson, Harris D. Bernstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e236f41f66004aaf9d50b8a6a3698135
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spelling	oai:doaj.org-article:e236f41f66004aaf9d50b8a6a36981352021-12-02T15:37:01ZFolding of a bacterial integral outer membrane protein is initiated in the periplasm10.1038/s41467-017-01246-42041-1723https://doaj.org/article/e236f41f66004aaf9d50b8a6a36981352017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01246-4https://doaj.org/toc/2041-1723The Bam complex promotes the insertion of β-barrel proteins (such as UpaG, a trimeric autotransporter adhesin) into the bacterial outer membrane. Here, Sikdar et al. show that UpaG β-barrel segments fold into a trimeric structure in the periplasm before they interact with the Bam complex.Rakesh SikdarJanine H. PetersonD. Eric AndersonHarris D. BernsteinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rakesh Sikdar Janine H. Peterson D. Eric Anderson Harris D. Bernstein Folding of a bacterial integral outer membrane protein is initiated in the periplasm
description	The Bam complex promotes the insertion of β-barrel proteins (such as UpaG, a trimeric autotransporter adhesin) into the bacterial outer membrane. Here, Sikdar et al. show that UpaG β-barrel segments fold into a trimeric structure in the periplasm before they interact with the Bam complex.
format	article
author	Rakesh Sikdar Janine H. Peterson D. Eric Anderson Harris D. Bernstein
author_facet	Rakesh Sikdar Janine H. Peterson D. Eric Anderson Harris D. Bernstein
author_sort	Rakesh Sikdar
title	Folding of a bacterial integral outer membrane protein is initiated in the periplasm
title_short	Folding of a bacterial integral outer membrane protein is initiated in the periplasm
title_full	Folding of a bacterial integral outer membrane protein is initiated in the periplasm
title_fullStr	Folding of a bacterial integral outer membrane protein is initiated in the periplasm
title_full_unstemmed	Folding of a bacterial integral outer membrane protein is initiated in the periplasm
title_sort	folding of a bacterial integral outer membrane protein is initiated in the periplasm
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e236f41f66004aaf9d50b8a6a3698135
work_keys_str_mv	AT rakeshsikdar foldingofabacterialintegraloutermembraneproteinisinitiatedintheperiplasm AT janinehpeterson foldingofabacterialintegraloutermembraneproteinisinitiatedintheperiplasm AT dericanderson foldingofabacterialintegraloutermembraneproteinisinitiatedintheperiplasm AT harrisdbernstein foldingofabacterialintegraloutermembraneproteinisinitiatedintheperiplasm
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Folding of a bacterial integral outer membrane protein is initiated in the periplasm

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