Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 6: Macrolides: tilmicosin, tylosin and tylvalosin

Abstract The specific concentrations of tilmicosin, tylosin and tylvalosin in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicro...

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Autores principales:	EFSA Panel on Biological Hazards (BIOHAZ), Konstantinos Koutsoumanis, Ana Allende, Avelino Alvarez‐Ordóñez, Declan Bolton, Sara Bover‐Cid, Marianne Chemaly, Robert Davies, Alessandra De Cesare, Lieve Herman, Friederike Hilbert, Roland Lindqvist, Maarten Nauta, Giuseppe Ru, Marion Simmons, Panagiotis Skandamis, Elisabetta Suffredini, Dan I Andersson, Vasileios Bampidis, Johan Bengtsson‐Palme, Damien Bouchard, Aude Ferran, Maryline Kouba, Secundino López Puente, Marta López‐Alonso, Søren Saxmose Nielsen, Alena Pechová, Mariana Petkova, Sebastien Girault, Alessandro Broglia, Beatriz Guerra, Matteo Lorenzo Innocenti, Ernesto Liébana, Gloria López‐Gálvez, Paola Manini, Pietro Stella, Luisa Peixe
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	tilmicosin tylosin tylvalosin antimicrobial resistance growth promotion yield increase Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/e237204c5fd64017a260af1546b075d8
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spelling	oai:doaj.org-article:e237204c5fd64017a260af1546b075d82021-11-23T08:30:51ZMaximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 6: Macrolides: tilmicosin, tylosin and tylvalosin1831-473210.2903/j.efsa.2021.6858https://doaj.org/article/e237204c5fd64017a260af1546b075d82021-10-01T00:00:00Zhttps://doi.org/10.2903/j.efsa.2021.6858https://doaj.org/toc/1831-4732Abstract The specific concentrations of tilmicosin, tylosin and tylvalosin in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield, were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for tilmicosin and tylosin, whilst for tylvalosin no suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these three antimicrobials.EFSA Panel on Biological Hazards (BIOHAZ)Konstantinos KoutsoumanisAna AllendeAvelino Alvarez‐OrdóñezDeclan BoltonSara Bover‐CidMarianne ChemalyRobert DaviesAlessandra De CesareLieve HermanFriederike HilbertRoland LindqvistMaarten NautaGiuseppe RuMarion SimmonsPanagiotis SkandamisElisabetta SuffrediniDan I AnderssonVasileios BampidisJohan Bengtsson‐PalmeDamien BouchardAude FerranMaryline KoubaSecundino López PuenteMarta López‐AlonsoSøren Saxmose NielsenAlena PechováMariana PetkovaSebastien GiraultAlessandro BrogliaBeatriz GuerraMatteo Lorenzo InnocentiErnesto LiébanaGloria López‐GálvezPaola ManiniPietro StellaLuisa PeixeWileyarticletilmicosintylosintylvalosinantimicrobial resistancegrowth promotionyield increaseNutrition. Foods and food supplyTX341-641Chemical technologyTP1-1185ENEFSA Journal, Vol 19, Iss 10, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tilmicosin tylosin tylvalosin antimicrobial resistance growth promotion yield increase Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185
spellingShingle	tilmicosin tylosin tylvalosin antimicrobial resistance growth promotion yield increase Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185 EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordóñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Giuseppe Ru Marion Simmons Panagiotis Skandamis Elisabetta Suffredini Dan I Andersson Vasileios Bampidis Johan Bengtsson‐Palme Damien Bouchard Aude Ferran Maryline Kouba Secundino López Puente Marta López‐Alonso Søren Saxmose Nielsen Alena Pechová Mariana Petkova Sebastien Girault Alessandro Broglia Beatriz Guerra Matteo Lorenzo Innocenti Ernesto Liébana Gloria López‐Gálvez Paola Manini Pietro Stella Luisa Peixe Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 6: Macrolides: tilmicosin, tylosin and tylvalosin
description	Abstract The specific concentrations of tilmicosin, tylosin and tylvalosin in non‐target feed for food‐producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield, were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for tilmicosin and tylosin, whilst for tylvalosin no suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these three antimicrobials.
format	article
author	EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordóñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Giuseppe Ru Marion Simmons Panagiotis Skandamis Elisabetta Suffredini Dan I Andersson Vasileios Bampidis Johan Bengtsson‐Palme Damien Bouchard Aude Ferran Maryline Kouba Secundino López Puente Marta López‐Alonso Søren Saxmose Nielsen Alena Pechová Mariana Petkova Sebastien Girault Alessandro Broglia Beatriz Guerra Matteo Lorenzo Innocenti Ernesto Liébana Gloria López‐Gálvez Paola Manini Pietro Stella Luisa Peixe
author_facet	EFSA Panel on Biological Hazards (BIOHAZ) Konstantinos Koutsoumanis Ana Allende Avelino Alvarez‐Ordóñez Declan Bolton Sara Bover‐Cid Marianne Chemaly Robert Davies Alessandra De Cesare Lieve Herman Friederike Hilbert Roland Lindqvist Maarten Nauta Giuseppe Ru Marion Simmons Panagiotis Skandamis Elisabetta Suffredini Dan I Andersson Vasileios Bampidis Johan Bengtsson‐Palme Damien Bouchard Aude Ferran Maryline Kouba Secundino López Puente Marta López‐Alonso Søren Saxmose Nielsen Alena Pechová Mariana Petkova Sebastien Girault Alessandro Broglia Beatriz Guerra Matteo Lorenzo Innocenti Ernesto Liébana Gloria López‐Gálvez Paola Manini Pietro Stella Luisa Peixe
author_sort	EFSA Panel on Biological Hazards (BIOHAZ)
title	Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 6: Macrolides: tilmicosin, tylosin and tylvalosin
title_short	Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 6: Macrolides: tilmicosin, tylosin and tylvalosin
title_full	Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 6: Macrolides: tilmicosin, tylosin and tylvalosin
title_fullStr	Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 6: Macrolides: tilmicosin, tylosin and tylvalosin
title_full_unstemmed	Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 6: Macrolides: tilmicosin, tylosin and tylvalosin
title_sort	maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. part 6: macrolides: tilmicosin, tylosin and tylvalosin
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/e237204c5fd64017a260af1546b075d8
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Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 6: Macrolides: tilmicosin, tylosin and tylvalosin

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Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 6: Macrolides: tilmicosin, tylosin and tylvalosin