Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential

Human saliva is a complex body fluid with more than 3000 different identified proteins. Besides rheological and lubricating properties, saliva supports wound healing and acts as an antimicrobial barrier. TFF peptides are secreted from the mucous acini of the major and minor salivary glands and are t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Werner Hoffmann
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	saliva artificial saliva esophagus TFF3 FCGBP DMBT1 Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e23769dd7f4247618de7e0989e6d08d7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e23769dd7f4247618de7e0989e6d08d7
record_format	dspace
spelling	oai:doaj.org-article:e23769dd7f4247618de7e0989e6d08d72021-11-25T17:54:27ZSalivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential10.3390/ijms2222122211422-00671661-6596https://doaj.org/article/e23769dd7f4247618de7e0989e6d08d72021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12221https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Human saliva is a complex body fluid with more than 3000 different identified proteins. Besides rheological and lubricating properties, saliva supports wound healing and acts as an antimicrobial barrier. TFF peptides are secreted from the mucous acini of the major and minor salivary glands and are typical constituents of normal saliva; TFF3 being the predominant peptide compared with TFF1 and TFF2. Only TFF3 is easily detectable by Western blotting. It occurs in two forms, a disulfide-linked homodimer (Mr: 13k) and a high-molecular-mass heterodimer with IgG Fc binding protein (FCGBP). TFF peptides are secretory lectins known for their protective effects in mucous epithelia; the TFF3 dimer probably has wound-healing properties due to its weak motogenic effect. There are multiple indications that FCGBP and TFF3-FCGBP play a key role in the innate immune defense of mucous epithelia. In addition, homodimeric TFF3 interacts in vitro with the salivary agglutinin DMBT1<sup>gp340</sup>. Here, the protective roles of TFF peptides, FCGBP, and DMBT1<sup>gp340</sup> in saliva are discussed. TFF peptides are also used to reduce radiotherapy- or chemotherapy-induced oral mucositis. Thus, TFF peptides, FCGBP, and DMBT1<sup>gp340</sup> are promising candidates for better formulations of artificial saliva, particularly improving wound healing and antimicrobial effects even in the esophagus.Werner HoffmannMDPI AGarticlesalivaartificial salivaesophagusTFF3FCGBPDMBT1Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12221, p 12221 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	saliva artificial saliva esophagus TFF3 FCGBP DMBT1 Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	saliva artificial saliva esophagus TFF3 FCGBP DMBT1 Biology (General) QH301-705.5 Chemistry QD1-999 Werner Hoffmann Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential
description	Human saliva is a complex body fluid with more than 3000 different identified proteins. Besides rheological and lubricating properties, saliva supports wound healing and acts as an antimicrobial barrier. TFF peptides are secreted from the mucous acini of the major and minor salivary glands and are typical constituents of normal saliva; TFF3 being the predominant peptide compared with TFF1 and TFF2. Only TFF3 is easily detectable by Western blotting. It occurs in two forms, a disulfide-linked homodimer (Mr: 13k) and a high-molecular-mass heterodimer with IgG Fc binding protein (FCGBP). TFF peptides are secretory lectins known for their protective effects in mucous epithelia; the TFF3 dimer probably has wound-healing properties due to its weak motogenic effect. There are multiple indications that FCGBP and TFF3-FCGBP play a key role in the innate immune defense of mucous epithelia. In addition, homodimeric TFF3 interacts in vitro with the salivary agglutinin DMBT1<sup>gp340</sup>. Here, the protective roles of TFF peptides, FCGBP, and DMBT1<sup>gp340</sup> in saliva are discussed. TFF peptides are also used to reduce radiotherapy- or chemotherapy-induced oral mucositis. Thus, TFF peptides, FCGBP, and DMBT1<sup>gp340</sup> are promising candidates for better formulations of artificial saliva, particularly improving wound healing and antimicrobial effects even in the esophagus.
format	article
author	Werner Hoffmann
author_facet	Werner Hoffmann
author_sort	Werner Hoffmann
title	Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential
title_short	Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential
title_full	Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential
title_fullStr	Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential
title_full_unstemmed	Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential
title_sort	salivary trefoil factor family (tff) peptides and their roles in oral and esophageal protection: therapeutic potential
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e23769dd7f4247618de7e0989e6d08d7
work_keys_str_mv	AT wernerhoffmann salivarytrefoilfactorfamilytffpeptidesandtheirrolesinoralandesophagealprotectiontherapeuticpotential
_version_	1718411894412279808

Salivary Trefoil Factor Family (TFF) Peptides and Their Roles in Oral and Esophageal Protection: Therapeutic Potential

Ejemplares similares