The inhibitory effect of quaternary ammonium salt on bacteria in root canal

Abstract Persisting apical periodontitis is a primary reason for multiple intervention in root canal. Persisting bacteria in root canal is related with the persisting infection. Despite the advancement in treatment strategies the persisting infection is a major challenge for endodontist. Here we tes...

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Autores principales:	Sanjay Kumar Tiwari, Xiao Guo, Yannan Huang, Xuedong Zhou, Hockin H. K. Xu, Biao Ren, Xian Peng, Michael D. Weir, Mingyun Li, Lei Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e23b5f996fa340458adc8391372511a4
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spelling	oai:doaj.org-article:e23b5f996fa340458adc8391372511a42021-12-02T15:07:53ZThe inhibitory effect of quaternary ammonium salt on bacteria in root canal10.1038/s41598-019-48666-42045-2322https://doaj.org/article/e23b5f996fa340458adc8391372511a42019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48666-4https://doaj.org/toc/2045-2322Abstract Persisting apical periodontitis is a primary reason for multiple intervention in root canal. Persisting bacteria in root canal is related with the persisting infection. Despite the advancement in treatment strategies the persisting infection is a major challenge for endodontist. Here we tested two newly developed quaternary ammonium methacrylates (QAMs) against endodontic bacteria and their biofilms. Their antibacterial and antibiofilm efficiency were compared with chlorhexidine (CHX) and sodium hypochlorite (NaOCl). We measured the MIC, MBC and MBIC of DMADDM and DMAHDM respectively. We also detected the ratio of live/dead bacteria and bacterial composition in the biofilms treated by DMADDM and DMAHDM. We found that DMADDM and DMAHDM could inhibit the growth of bacteria and biofilms formation. The result showed that novel QAMs were remarkably efficient than CHX against biofilms. In addition, we found that Streptococcus gordonii (S. gordonii) and Enterococcus faecalis (E. faecalis) were frequent isolates after treatment with antimicrobial compounds.Sanjay Kumar TiwariXiao GuoYannan HuangXuedong ZhouHockin H. K. XuBiao RenXian PengMichael D. WeirMingyun LiLei ChengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanjay Kumar Tiwari Xiao Guo Yannan Huang Xuedong Zhou Hockin H. K. Xu Biao Ren Xian Peng Michael D. Weir Mingyun Li Lei Cheng The inhibitory effect of quaternary ammonium salt on bacteria in root canal
description	Abstract Persisting apical periodontitis is a primary reason for multiple intervention in root canal. Persisting bacteria in root canal is related with the persisting infection. Despite the advancement in treatment strategies the persisting infection is a major challenge for endodontist. Here we tested two newly developed quaternary ammonium methacrylates (QAMs) against endodontic bacteria and their biofilms. Their antibacterial and antibiofilm efficiency were compared with chlorhexidine (CHX) and sodium hypochlorite (NaOCl). We measured the MIC, MBC and MBIC of DMADDM and DMAHDM respectively. We also detected the ratio of live/dead bacteria and bacterial composition in the biofilms treated by DMADDM and DMAHDM. We found that DMADDM and DMAHDM could inhibit the growth of bacteria and biofilms formation. The result showed that novel QAMs were remarkably efficient than CHX against biofilms. In addition, we found that Streptococcus gordonii (S. gordonii) and Enterococcus faecalis (E. faecalis) were frequent isolates after treatment with antimicrobial compounds.
format	article
author	Sanjay Kumar Tiwari Xiao Guo Yannan Huang Xuedong Zhou Hockin H. K. Xu Biao Ren Xian Peng Michael D. Weir Mingyun Li Lei Cheng
author_facet	Sanjay Kumar Tiwari Xiao Guo Yannan Huang Xuedong Zhou Hockin H. K. Xu Biao Ren Xian Peng Michael D. Weir Mingyun Li Lei Cheng
author_sort	Sanjay Kumar Tiwari
title	The inhibitory effect of quaternary ammonium salt on bacteria in root canal
title_short	The inhibitory effect of quaternary ammonium salt on bacteria in root canal
title_full	The inhibitory effect of quaternary ammonium salt on bacteria in root canal
title_fullStr	The inhibitory effect of quaternary ammonium salt on bacteria in root canal
title_full_unstemmed	The inhibitory effect of quaternary ammonium salt on bacteria in root canal
title_sort	inhibitory effect of quaternary ammonium salt on bacteria in root canal
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e23b5f996fa340458adc8391372511a4
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The inhibitory effect of quaternary ammonium salt on bacteria in root canal

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