Targeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide

The high surface area and the possibility of surface functionalization associated with a high biocompatibility endow graphene oxide with a great potential for biomedical applications. Although this material has been widely investigated for cancer therapy, it has been scarcely used for the treatment...

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Autores principales:	Laura Muzi, Cécile Seifert, Rym Soltani, Cécilia Ménard-Moyon, Hélène Dumortier, Alberto Bianco
Formato:	article
Lenguaje:	EN
Publicado:	Wiley-VCH 2021
Materias:	B cells cancer carbon materials lysozyme supramolecular complexes Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/e23b6be94bc94d988af9c5457e12e7de
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spelling	oai:doaj.org-article:e23b6be94bc94d988af9c5457e12e7de2021-11-06T04:12:26ZTargeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide2699-930710.1002/anbr.202100060https://doaj.org/article/e23b6be94bc94d988af9c5457e12e7de2021-11-01T00:00:00Zhttps://doi.org/10.1002/anbr.202100060https://doaj.org/toc/2699-9307The high surface area and the possibility of surface functionalization associated with a high biocompatibility endow graphene oxide with a great potential for biomedical applications. Although this material has been widely investigated for cancer therapy, it has been scarcely used for the treatment of autoimmune diseases. Herein, graphene oxide–lysozyme stable conjugates are prepared by a straightforward noncovalent functionalization approach. The complexes are able to selectively target a B lymphocyte cell model, which expresses a lysozyme‐specific B cell receptor. The results suggest the use of graphene oxide as a promising nanocarrier for the targeted therapy of B‐cell‐mediated autoimmune diseases, allowing overcoming the severe inconveniences associated with available B‐cell‐targeted therapies.Laura MuziCécile SeifertRym SoltaniCécilia Ménard-MoyonHélène DumortierAlberto BiancoWiley-VCHarticleB cellscancercarbon materialslysozymesupramolecular complexesBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENAdvanced NanoBiomed Research, Vol 1, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	B cells cancer carbon materials lysozyme supramolecular complexes Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	B cells cancer carbon materials lysozyme supramolecular complexes Biotechnology TP248.13-248.65 Medical technology R855-855.5 Laura Muzi Cécile Seifert Rym Soltani Cécilia Ménard-Moyon Hélène Dumortier Alberto Bianco Targeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide
description	The high surface area and the possibility of surface functionalization associated with a high biocompatibility endow graphene oxide with a great potential for biomedical applications. Although this material has been widely investigated for cancer therapy, it has been scarcely used for the treatment of autoimmune diseases. Herein, graphene oxide–lysozyme stable conjugates are prepared by a straightforward noncovalent functionalization approach. The complexes are able to selectively target a B lymphocyte cell model, which expresses a lysozyme‐specific B cell receptor. The results suggest the use of graphene oxide as a promising nanocarrier for the targeted therapy of B‐cell‐mediated autoimmune diseases, allowing overcoming the severe inconveniences associated with available B‐cell‐targeted therapies.
format	article
author	Laura Muzi Cécile Seifert Rym Soltani Cécilia Ménard-Moyon Hélène Dumortier Alberto Bianco
author_facet	Laura Muzi Cécile Seifert Rym Soltani Cécilia Ménard-Moyon Hélène Dumortier Alberto Bianco
author_sort	Laura Muzi
title	Targeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide
title_short	Targeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide
title_full	Targeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide
title_fullStr	Targeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide
title_full_unstemmed	Targeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide
title_sort	targeting b lymphocytes using protein‐functionalized graphene oxide
publisher	Wiley-VCH
publishDate	2021
url	https://doaj.org/article/e23b6be94bc94d988af9c5457e12e7de
work_keys_str_mv	AT lauramuzi targetingblymphocytesusingproteinfunctionalizedgrapheneoxide AT cecileseifert targetingblymphocytesusingproteinfunctionalizedgrapheneoxide AT rymsoltani targetingblymphocytesusingproteinfunctionalizedgrapheneoxide AT ceciliamenardmoyon targetingblymphocytesusingproteinfunctionalizedgrapheneoxide AT helenedumortier targetingblymphocytesusingproteinfunctionalizedgrapheneoxide AT albertobianco targetingblymphocytesusingproteinfunctionalizedgrapheneoxide
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Targeting B Lymphocytes Using Protein‐Functionalized Graphene Oxide

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