Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma

Abstract Background The prognostic significance of ALK rearrangement is still contradictory. Here, we aimed to investigate the clinical characteristics and outcomes of lung adenocarcinoma patients with ALK rearrangement, and analyze whether these patients benefited from targeted therapy. Methods Thi...

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Autores principales:	Huan Zhang, Guangyao Shan, Benjie Cai, Guoshu Bi, Zhencong Chen, Jiaqi Liang, Valeria Besskaya, Yuansheng Zheng, Weigang Guo, Lin Wang, Songtao Xu, Cheng Zhan
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	ALK inhibitors anaplastic lymphoma kinase (ALK) clinical feature lung adenocarcinoma prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e23db13d01294df99cedda91404918e2
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spelling	oai:doaj.org-article:e23db13d01294df99cedda91404918e22021-11-14T23:28:25ZClinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma1759-77141759-770610.1111/1759-7714.14170https://doaj.org/article/e23db13d01294df99cedda91404918e22021-11-01T00:00:00Zhttps://doi.org/10.1111/1759-7714.14170https://doaj.org/toc/1759-7706https://doaj.org/toc/1759-7714Abstract Background The prognostic significance of ALK rearrangement is still contradictory. Here, we aimed to investigate the clinical characteristics and outcomes of lung adenocarcinoma patients with ALK rearrangement, and analyze whether these patients benefited from targeted therapy. Methods This was a retrospective cohort study of 80 ALK‐rearranged lung adenocarcinoma patients who had undergone radical surgery and another 3031 ALK mutation‐negative patients were retrospectively reviewed for inclusion in this case‐controlled analyses. Overall survival (OS) was evaluated using the Kaplan‐–Meier method. Univariate analysis (UVA) and multivariate analysis (MVA) by the Cox proportional hazards regression identified risk factors that predicted OS. Results Compared to ALK‐negative patients, the ALK rearranged patients were younger, with more non‐smokers, more females, a larger primary tumor was demonstrated, and were a higher pathological stage. In particular, the risk of lymph node metastasis was higher. For patients with surgically‐resected tumors, the prognosis was better for ALK rearranged patients (HR = 0.503; 95% CI: 0.259–0.974, p = 0.041). In addition, for stage II–III patients, targeted therapy was an independent prognostic factor of better OS (HR = 0.159; 95% CI: 0.032–0.801, p = 0.026). Conclusions ALK rearranged lung adenocarcinoma patients who have undergone radical surgery have distinct clinical features. Patients with ALK rearrangement may have a favorable prognosis, and stage II–III patients may benefit from targeted treatment.Huan ZhangGuangyao ShanBenjie CaiGuoshu BiZhencong ChenJiaqi LiangValeria BesskayaYuansheng ZhengWeigang GuoLin WangSongtao XuCheng ZhanWileyarticleALK inhibitorsanaplastic lymphoma kinase (ALK)clinical featurelung adenocarcinomaprognosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENThoracic Cancer, Vol 12, Iss 22, Pp 3011-3018 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ALK inhibitors anaplastic lymphoma kinase (ALK) clinical feature lung adenocarcinoma prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ALK inhibitors anaplastic lymphoma kinase (ALK) clinical feature lung adenocarcinoma prognosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Huan Zhang Guangyao Shan Benjie Cai Guoshu Bi Zhencong Chen Jiaqi Liang Valeria Besskaya Yuansheng Zheng Weigang Guo Lin Wang Songtao Xu Cheng Zhan Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma
description	Abstract Background The prognostic significance of ALK rearrangement is still contradictory. Here, we aimed to investigate the clinical characteristics and outcomes of lung adenocarcinoma patients with ALK rearrangement, and analyze whether these patients benefited from targeted therapy. Methods This was a retrospective cohort study of 80 ALK‐rearranged lung adenocarcinoma patients who had undergone radical surgery and another 3031 ALK mutation‐negative patients were retrospectively reviewed for inclusion in this case‐controlled analyses. Overall survival (OS) was evaluated using the Kaplan‐–Meier method. Univariate analysis (UVA) and multivariate analysis (MVA) by the Cox proportional hazards regression identified risk factors that predicted OS. Results Compared to ALK‐negative patients, the ALK rearranged patients were younger, with more non‐smokers, more females, a larger primary tumor was demonstrated, and were a higher pathological stage. In particular, the risk of lymph node metastasis was higher. For patients with surgically‐resected tumors, the prognosis was better for ALK rearranged patients (HR = 0.503; 95% CI: 0.259–0.974, p = 0.041). In addition, for stage II–III patients, targeted therapy was an independent prognostic factor of better OS (HR = 0.159; 95% CI: 0.032–0.801, p = 0.026). Conclusions ALK rearranged lung adenocarcinoma patients who have undergone radical surgery have distinct clinical features. Patients with ALK rearrangement may have a favorable prognosis, and stage II–III patients may benefit from targeted treatment.
format	article
author	Huan Zhang Guangyao Shan Benjie Cai Guoshu Bi Zhencong Chen Jiaqi Liang Valeria Besskaya Yuansheng Zheng Weigang Guo Lin Wang Songtao Xu Cheng Zhan
author_facet	Huan Zhang Guangyao Shan Benjie Cai Guoshu Bi Zhencong Chen Jiaqi Liang Valeria Besskaya Yuansheng Zheng Weigang Guo Lin Wang Songtao Xu Cheng Zhan
author_sort	Huan Zhang
title	Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma
title_short	Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma
title_full	Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma
title_fullStr	Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma
title_full_unstemmed	Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma
title_sort	clinicopathological and prognostic implications of alk rearrangement in patients with completely surgically resected lung adenocarcinoma
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/e23db13d01294df99cedda91404918e2
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_version_	1718429015464738816

Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma

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