The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma

Abstract In this study, we investigated the correlation between pattern electroretinogram (PERG) and optical coherence tomography angiography (OCTA) parameters for diagnosis in patients with normal-tension glaucoma (NTG). Forty-nine normal individuals (49 eyes) and 60 patients with NTG (60 eyes) wer...

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Autores principales:	Sang Yeop Lee, Nak-Hoon Son, Hyoung Won Bae, Gong Je Seong, Chan Yun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e23efe58584849d2904c80aa348c4b7a
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spelling	oai:doaj.org-article:e23efe58584849d2904c80aa348c4b7a2021-12-02T17:52:26ZThe role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma10.1038/s41598-021-91813-z2045-2322https://doaj.org/article/e23efe58584849d2904c80aa348c4b7a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91813-zhttps://doaj.org/toc/2045-2322Abstract In this study, we investigated the correlation between pattern electroretinogram (PERG) and optical coherence tomography angiography (OCTA) parameters for diagnosis in patients with normal-tension glaucoma (NTG). Forty-nine normal individuals (49 eyes) and 60 patients with NTG (60 eyes) were enrolled. OCTA and PERG parameters, such as macular vessel density (VD) and the amplitude of N35–P50 and P50–N95, were measured. Correlation analyses were performed between the parameters, and the area under the curve (AUC) was used to identify their diagnostic ability for NTG. Macular VD and the amplitude of N35–P50 and P50–N95 showed significant differences between the normal individuals and patients with NTG. Correlation between P50 and N95 amplitude and macular VD was significant in the normal and early glaucoma groups. Macular VD showed a higher AUC value (0.730) than that of P50–N95 amplitude (0.645) in the early glaucoma group. In the moderate to severe glaucoma group, the AUC value of the amplitude of P50–N95 (0.907) was higher than that of macular VD (0.876). The results indicate that PERG and OCTA parameters may identify glaucoma in its early stage, based on the severity of glaucomatous damage in patients with NTG.Sang Yeop LeeNak-Hoon SonHyoung Won BaeGong Je SeongChan Yun KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sang Yeop Lee Nak-Hoon Son Hyoung Won Bae Gong Je Seong Chan Yun Kim The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma
description	Abstract In this study, we investigated the correlation between pattern electroretinogram (PERG) and optical coherence tomography angiography (OCTA) parameters for diagnosis in patients with normal-tension glaucoma (NTG). Forty-nine normal individuals (49 eyes) and 60 patients with NTG (60 eyes) were enrolled. OCTA and PERG parameters, such as macular vessel density (VD) and the amplitude of N35–P50 and P50–N95, were measured. Correlation analyses were performed between the parameters, and the area under the curve (AUC) was used to identify their diagnostic ability for NTG. Macular VD and the amplitude of N35–P50 and P50–N95 showed significant differences between the normal individuals and patients with NTG. Correlation between P50 and N95 amplitude and macular VD was significant in the normal and early glaucoma groups. Macular VD showed a higher AUC value (0.730) than that of P50–N95 amplitude (0.645) in the early glaucoma group. In the moderate to severe glaucoma group, the AUC value of the amplitude of P50–N95 (0.907) was higher than that of macular VD (0.876). The results indicate that PERG and OCTA parameters may identify glaucoma in its early stage, based on the severity of glaucomatous damage in patients with NTG.
format	article
author	Sang Yeop Lee Nak-Hoon Son Hyoung Won Bae Gong Je Seong Chan Yun Kim
author_facet	Sang Yeop Lee Nak-Hoon Son Hyoung Won Bae Gong Je Seong Chan Yun Kim
author_sort	Sang Yeop Lee
title	The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma
title_short	The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma
title_full	The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma
title_fullStr	The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma
title_full_unstemmed	The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma
title_sort	role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e23efe58584849d2904c80aa348c4b7a
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The role of pattern electroretinograms and optical coherence tomography angiography in the diagnosis of normal-tension glaucoma

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