Infliximab in Combination with Low-Dose Acitretin in Generalized Pustular Psoriasis: A Report of Two Cases and Review of the Literature

Marta Ko&lstrok;t-Kami&nacute;ska, Magdalena &Zdot;ychowska, Adam Reich Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszów University, Rzeszów, PolandCorrespondence: Magdalena &Zdot;ychowskaDepartment of Dermatology, Institute of Medical Sciences, Me...

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Autores principales:	Kołt-Kamińska M, Żychowska M, Reich A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	infliximab anti-tnfα generalized pustular psoriasis acitretin Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e241a586631c40368051ac1487dd9901
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spelling	oai:doaj.org-article:e241a586631c40368051ac1487dd99012021-12-02T16:35:43ZInfliximab in Combination with Low-Dose Acitretin in Generalized Pustular Psoriasis: A Report of Two Cases and Review of the Literature1177-5491https://doaj.org/article/e241a586631c40368051ac1487dd99012021-08-01T00:00:00Zhttps://www.dovepress.com/infliximab-in-combination-with-low-dose-acitretin-in-generalized-pustu-peer-reviewed-fulltext-article-BTThttps://doaj.org/toc/1177-5491Marta Ko&lstrok;t-Kami&nacute;ska, Magdalena &Zdot;ychowska, Adam Reich Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszów University, Rzeszów, PolandCorrespondence: Magdalena &Zdot;ychowskaDepartment of Dermatology, Institute of Medical Sciences, Medical College of Rzeszów University, Reszów, PolandTel +48 66-942-2237Fax +48 17 86 66 294Email magda.zychowska@gmail.comAbstract: Generalized pustular psoriasis (GPP) is a severe, life-threatening disease that represents a major therapeutic challenge. There is a lack of randomized controlled trials assessing the efficacy of various treatment options for GPP. TNFα inhibitors have proven to be effective and are increasingly used in this indication. In the current paper, we present two patients with GPP treated with infliximab (Ifx) and a literature review appraising currently available data on the use of Ifx in GPP. Case 1 was a 73-year-old woman with GPP who exhibited lack of treatment response or primary intolerance to standard therapeutic options (high-dose acitretin, methotrexate, cyclosporine A, and methylprednisolone). However, Ifx therapy combined with low-dose acitretin resulted in rapid and sustained resolution of skin lesions. Case 2 was a 60-year-old man with GPP and numerous comorbidities who was initially treated with Ifx in combination with methotrexate, with good treatment response for 9 months. Following an infection-induced flare of GPP at week 38, methotrexate was discontinued in favor of low-dose acitretin and Ifx continued. This regimen again resulted in rapid resolution of pustules. We present these cases to highlight the advantage of long-term Ifx therapy with low-dose acitretin in GPP.Keywords: infliximab, anti-TNFα, generalized pustular psoriasis, acitretinKołt-Kamińska MŻychowska MReich ADove Medical Pressarticleinfliximabanti-tnfαgeneralized pustular psoriasisacitretinMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 15, Pp 317-327 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	infliximab anti-tnfα generalized pustular psoriasis acitretin Medicine (General) R5-920
spellingShingle	infliximab anti-tnfα generalized pustular psoriasis acitretin Medicine (General) R5-920 Kołt-Kamińska M Żychowska M Reich A Infliximab in Combination with Low-Dose Acitretin in Generalized Pustular Psoriasis: A Report of Two Cases and Review of the Literature
description	Marta Ko&lstrok;t-Kami&nacute;ska, Magdalena &Zdot;ychowska, Adam Reich Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszów University, Rzeszów, PolandCorrespondence: Magdalena &Zdot;ychowskaDepartment of Dermatology, Institute of Medical Sciences, Medical College of Rzeszów University, Reszów, PolandTel +48 66-942-2237Fax +48 17 86 66 294Email magda.zychowska@gmail.comAbstract: Generalized pustular psoriasis (GPP) is a severe, life-threatening disease that represents a major therapeutic challenge. There is a lack of randomized controlled trials assessing the efficacy of various treatment options for GPP. TNFα inhibitors have proven to be effective and are increasingly used in this indication. In the current paper, we present two patients with GPP treated with infliximab (Ifx) and a literature review appraising currently available data on the use of Ifx in GPP. Case 1 was a 73-year-old woman with GPP who exhibited lack of treatment response or primary intolerance to standard therapeutic options (high-dose acitretin, methotrexate, cyclosporine A, and methylprednisolone). However, Ifx therapy combined with low-dose acitretin resulted in rapid and sustained resolution of skin lesions. Case 2 was a 60-year-old man with GPP and numerous comorbidities who was initially treated with Ifx in combination with methotrexate, with good treatment response for 9 months. Following an infection-induced flare of GPP at week 38, methotrexate was discontinued in favor of low-dose acitretin and Ifx continued. This regimen again resulted in rapid resolution of pustules. We present these cases to highlight the advantage of long-term Ifx therapy with low-dose acitretin in GPP.Keywords: infliximab, anti-TNFα, generalized pustular psoriasis, acitretin
format	article
author	Kołt-Kamińska M Żychowska M Reich A
author_facet	Kołt-Kamińska M Żychowska M Reich A
author_sort	Kołt-Kamińska M
title	Infliximab in Combination with Low-Dose Acitretin in Generalized Pustular Psoriasis: A Report of Two Cases and Review of the Literature
title_short	Infliximab in Combination with Low-Dose Acitretin in Generalized Pustular Psoriasis: A Report of Two Cases and Review of the Literature
title_full	Infliximab in Combination with Low-Dose Acitretin in Generalized Pustular Psoriasis: A Report of Two Cases and Review of the Literature
title_fullStr	Infliximab in Combination with Low-Dose Acitretin in Generalized Pustular Psoriasis: A Report of Two Cases and Review of the Literature
title_full_unstemmed	Infliximab in Combination with Low-Dose Acitretin in Generalized Pustular Psoriasis: A Report of Two Cases and Review of the Literature
title_sort	infliximab in combination with low-dose acitretin in generalized pustular psoriasis: a report of two cases and review of the literature
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e241a586631c40368051ac1487dd9901
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Infliximab in Combination with Low-Dose Acitretin in Generalized Pustular Psoriasis: A Report of Two Cases and Review of the Literature

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