Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation

Single-cell RNA sequencing allows characterizing cell-to-cell heterogeneity at transcriptome scale. Here, the authors present an approach that enables microRNA and mRNA sequencing in the same single cell, providing insights into the origins of non-genetic cellular variability and mechanisms of miRNA...

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Autores principales:	Nayi Wang, Ji Zheng, Zhuo Chen, Yang Liu, Burak Dura, Minsuk Kwak, Juliana Xavier-Ferrucio, Yi-Chien Lu, Miaomiao Zhang, Christine Roden, Jijun Cheng, Diane S. Krause, Ye Ding, Rong Fan, Jun Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e2431a74f7624f76899b665eb1437ac2
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spelling	oai:doaj.org-article:e2431a74f7624f76899b665eb1437ac22021-12-02T15:35:28ZSingle-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation10.1038/s41467-018-07981-62041-1723https://doaj.org/article/e2431a74f7624f76899b665eb1437ac22019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07981-6https://doaj.org/toc/2041-1723Single-cell RNA sequencing allows characterizing cell-to-cell heterogeneity at transcriptome scale. Here, the authors present an approach that enables microRNA and mRNA sequencing in the same single cell, providing insights into the origins of non-genetic cellular variability and mechanisms of miRNA regulation.Nayi WangJi ZhengZhuo ChenYang LiuBurak DuraMinsuk KwakJuliana Xavier-FerrucioYi-Chien LuMiaomiao ZhangChristine RodenJijun ChengDiane S. KrauseYe DingRong FanJun LuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nayi Wang Ji Zheng Zhuo Chen Yang Liu Burak Dura Minsuk Kwak Juliana Xavier-Ferrucio Yi-Chien Lu Miaomiao Zhang Christine Roden Jijun Cheng Diane S. Krause Ye Ding Rong Fan Jun Lu Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
description	Single-cell RNA sequencing allows characterizing cell-to-cell heterogeneity at transcriptome scale. Here, the authors present an approach that enables microRNA and mRNA sequencing in the same single cell, providing insights into the origins of non-genetic cellular variability and mechanisms of miRNA regulation.
format	article
author	Nayi Wang Ji Zheng Zhuo Chen Yang Liu Burak Dura Minsuk Kwak Juliana Xavier-Ferrucio Yi-Chien Lu Miaomiao Zhang Christine Roden Jijun Cheng Diane S. Krause Ye Ding Rong Fan Jun Lu
author_facet	Nayi Wang Ji Zheng Zhuo Chen Yang Liu Burak Dura Minsuk Kwak Juliana Xavier-Ferrucio Yi-Chien Lu Miaomiao Zhang Christine Roden Jijun Cheng Diane S. Krause Ye Ding Rong Fan Jun Lu
author_sort	Nayi Wang
title	Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
title_short	Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
title_full	Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
title_fullStr	Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
title_full_unstemmed	Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation
title_sort	single-cell microrna-mrna co-sequencing reveals non-genetic heterogeneity and mechanisms of microrna regulation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e2431a74f7624f76899b665eb1437ac2
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Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation

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