Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos, suggesting that M-decay and Z-decay pathways may reg...

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Autores principales:	Qian-Qian Sha, Wei Zheng, Yun-Wen Wu, Sen Li, Lei Guo, Shuoping Zhang, Ge Lin, Xiang-Hong Ou, Heng-Yu Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e246ffb072c949edb55bfd5a4212656f
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spelling	oai:doaj.org-article:e246ffb072c949edb55bfd5a4212656f2021-12-02T19:16:55ZDynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans10.1038/s41467-020-18680-62041-1723https://doaj.org/article/e246ffb072c949edb55bfd5a4212656f2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18680-6https://doaj.org/toc/2041-1723How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos, suggesting that M-decay and Z-decay pathways may regulate such early development.Qian-Qian ShaWei ZhengYun-Wen WuSen LiLei GuoShuoping ZhangGe LinXiang-Hong OuHeng-Yu FanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian-Qian Sha Wei Zheng Yun-Wen Wu Sen Li Lei Guo Shuoping Zhang Ge Lin Xiang-Hong Ou Heng-Yu Fan Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
description	How maternal RNA clearance is regulated in human preimplantation embryos is unclear. Here, the authors show there is a potential correlation between maternal mRNA decay defects and early developmental arrest from in vitro fertilized human embryos, suggesting that M-decay and Z-decay pathways may regulate such early development.
format	article
author	Qian-Qian Sha Wei Zheng Yun-Wen Wu Sen Li Lei Guo Shuoping Zhang Ge Lin Xiang-Hong Ou Heng-Yu Fan
author_facet	Qian-Qian Sha Wei Zheng Yun-Wen Wu Sen Li Lei Guo Shuoping Zhang Ge Lin Xiang-Hong Ou Heng-Yu Fan
author_sort	Qian-Qian Sha
title	Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
title_short	Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
title_full	Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
title_fullStr	Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
title_full_unstemmed	Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans
title_sort	dynamics and clinical relevance of maternal mrna clearance during the oocyte-to-embryo transition in humans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e246ffb072c949edb55bfd5a4212656f
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Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans

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