The origin of novel avian influenza A (H7N9) and mutation dynamics for its human-to-human transmissible capacity.

In February 2013, H7N9 (A/H7N9/2013_China), a novel avian influenza virus, broke out in eastern China and caused human death. It is a global priority to discover its origin and the point in time at which it will become transmittable between humans. We present here an interdisciplinary method to trac...

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Autores principales:	Jin Peng, Hao Yang, Hua Jiang, Yi-xiao Lin, Charles Damien Lu, Ya-wei Xu, Jun Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e24730fa3a8a4e68aaa3668e8cd2ea0c
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spelling	oai:doaj.org-article:e24730fa3a8a4e68aaa3668e8cd2ea0c2021-11-18T08:26:01ZThe origin of novel avian influenza A (H7N9) and mutation dynamics for its human-to-human transmissible capacity.1932-620310.1371/journal.pone.0093094https://doaj.org/article/e24730fa3a8a4e68aaa3668e8cd2ea0c2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24671138/?tool=EBIhttps://doaj.org/toc/1932-6203In February 2013, H7N9 (A/H7N9/2013_China), a novel avian influenza virus, broke out in eastern China and caused human death. It is a global priority to discover its origin and the point in time at which it will become transmittable between humans. We present here an interdisciplinary method to track the origin of H7N9 virus in China and to establish an evolutionary dynamics model for its human-to-human transmission via mutations. After comparing influenza viruses from China since 1983, we established an A/H7N9/2013_China virus evolutionary phylogenetic tree and found that the human instances of virus infection were of avian origin and clustered into an independent line. Comparing hemagglutinin (HA) and neuraminidase (NA) gene sequences of A/H7N9/2013_China viruses with all human-to-human, avian, and swine influenza viruses in China in the past 30 years, we found that A/H7N9/2013_China viruses originated from Baer's Pochard H7N1 virus of Hu Nan Province 2010 (HA gene, EPI: 370846, similarity with H7N9 is 95.5%) and duck influenza viruses of Nanchang city 2000 (NA gene, EPI: 387555, similarity with H7N9 is 97%) through genetic re-assortment. HA and NA gene sequence comparison indicated that A/H7N9/2013_China virus was not similar to human-to-human transmittable influenza viruses. To simulate the evolution dynamics required for human-to-human transmission mutations of H7N9 virus, we employed the Markov model. The result of this calculation indicated that the virus would acquire properties for human-to-human transmission in 11.3 years (95% confidence interval (CI): 11.2-11.3, HA gene).Jin PengHao YangHua JiangYi-xiao LinCharles Damien LuYa-wei XuJun ZengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e93094 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jin Peng Hao Yang Hua Jiang Yi-xiao Lin Charles Damien Lu Ya-wei Xu Jun Zeng The origin of novel avian influenza A (H7N9) and mutation dynamics for its human-to-human transmissible capacity.
description	In February 2013, H7N9 (A/H7N9/2013_China), a novel avian influenza virus, broke out in eastern China and caused human death. It is a global priority to discover its origin and the point in time at which it will become transmittable between humans. We present here an interdisciplinary method to track the origin of H7N9 virus in China and to establish an evolutionary dynamics model for its human-to-human transmission via mutations. After comparing influenza viruses from China since 1983, we established an A/H7N9/2013_China virus evolutionary phylogenetic tree and found that the human instances of virus infection were of avian origin and clustered into an independent line. Comparing hemagglutinin (HA) and neuraminidase (NA) gene sequences of A/H7N9/2013_China viruses with all human-to-human, avian, and swine influenza viruses in China in the past 30 years, we found that A/H7N9/2013_China viruses originated from Baer's Pochard H7N1 virus of Hu Nan Province 2010 (HA gene, EPI: 370846, similarity with H7N9 is 95.5%) and duck influenza viruses of Nanchang city 2000 (NA gene, EPI: 387555, similarity with H7N9 is 97%) through genetic re-assortment. HA and NA gene sequence comparison indicated that A/H7N9/2013_China virus was not similar to human-to-human transmittable influenza viruses. To simulate the evolution dynamics required for human-to-human transmission mutations of H7N9 virus, we employed the Markov model. The result of this calculation indicated that the virus would acquire properties for human-to-human transmission in 11.3 years (95% confidence interval (CI): 11.2-11.3, HA gene).
format	article
author	Jin Peng Hao Yang Hua Jiang Yi-xiao Lin Charles Damien Lu Ya-wei Xu Jun Zeng
author_facet	Jin Peng Hao Yang Hua Jiang Yi-xiao Lin Charles Damien Lu Ya-wei Xu Jun Zeng
author_sort	Jin Peng
title	The origin of novel avian influenza A (H7N9) and mutation dynamics for its human-to-human transmissible capacity.
title_short	The origin of novel avian influenza A (H7N9) and mutation dynamics for its human-to-human transmissible capacity.
title_full	The origin of novel avian influenza A (H7N9) and mutation dynamics for its human-to-human transmissible capacity.
title_fullStr	The origin of novel avian influenza A (H7N9) and mutation dynamics for its human-to-human transmissible capacity.
title_full_unstemmed	The origin of novel avian influenza A (H7N9) and mutation dynamics for its human-to-human transmissible capacity.
title_sort	origin of novel avian influenza a (h7n9) and mutation dynamics for its human-to-human transmissible capacity.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/e24730fa3a8a4e68aaa3668e8cd2ea0c
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The origin of novel avian influenza A (H7N9) and mutation dynamics for its human-to-human transmissible capacity.

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