Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea

Abstract Allergic rhinitis (AR) and diabetes mellitus (DM) share a common cause in inflammation; however, potential relationships between them are not clear. Therefore, we aimed to explore the associations between AR and DM. In this cross-sectional study, data were extracted from the Korean National...

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Autores principales:	Tae Kyung Lee, Ye Jin Jeon, Sun Jae Jung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e248fa6dfaf6435cac120d6003d05a44
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spelling	oai:doaj.org-article:e248fa6dfaf6435cac120d6003d05a442021-12-02T16:23:14ZBi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea10.1038/s41598-021-83787-92045-2322https://doaj.org/article/e248fa6dfaf6435cac120d6003d05a442021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83787-9https://doaj.org/toc/2045-2322Abstract Allergic rhinitis (AR) and diabetes mellitus (DM) share a common cause in inflammation; however, potential relationships between them are not clear. Therefore, we aimed to explore the associations between AR and DM. In this cross-sectional study, data were extracted from the Korean National Health and Nutrition Examination Survey 2007–2018 and weighted based on sociodemographic characters. AR and DM were defined by diagnoses thereof. Since self-reporting was not perfect, in order to complement the validity, we additionally performed sensitivity analysis by defining DM according to HbA1c and medication history. After excluding invalid data, the number of final participants was 29,246 (mean age, 54.95 ± 14.27 years). We calculated the odds ratio (OR) of newly self-reported DM among AR patients without DM history by multivariable logistic regression adjusted for potential confounders. A reverse association was also assessed. Patients with AR showed lower ORs for DM than those without AR (OR, 95% CI: men, 0.28, 0.19–0.42; women, 0.33, 0.24–0.46). Similarly, DM patients showed lower ORs for AR than patients without DM (men, 0.41, 0.31–0.56; women, 0.34, 0.25–0.46). The same results were obtained in sensitivity analysis defining DM according to HbA1c levels or DM treatment and in stratification analysis for age, residency, comorbidity, BMI, and menopause. In conclusion, we discovered that AR and DM show mutual inverse associations, regardless of sex, in individuals aged 30 years and older.Tae Kyung LeeYe Jin JeonSun Jae JungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tae Kyung Lee Ye Jin Jeon Sun Jae Jung Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea
description	Abstract Allergic rhinitis (AR) and diabetes mellitus (DM) share a common cause in inflammation; however, potential relationships between them are not clear. Therefore, we aimed to explore the associations between AR and DM. In this cross-sectional study, data were extracted from the Korean National Health and Nutrition Examination Survey 2007–2018 and weighted based on sociodemographic characters. AR and DM were defined by diagnoses thereof. Since self-reporting was not perfect, in order to complement the validity, we additionally performed sensitivity analysis by defining DM according to HbA1c and medication history. After excluding invalid data, the number of final participants was 29,246 (mean age, 54.95 ± 14.27 years). We calculated the odds ratio (OR) of newly self-reported DM among AR patients without DM history by multivariable logistic regression adjusted for potential confounders. A reverse association was also assessed. Patients with AR showed lower ORs for DM than those without AR (OR, 95% CI: men, 0.28, 0.19–0.42; women, 0.33, 0.24–0.46). Similarly, DM patients showed lower ORs for AR than patients without DM (men, 0.41, 0.31–0.56; women, 0.34, 0.25–0.46). The same results were obtained in sensitivity analysis defining DM according to HbA1c levels or DM treatment and in stratification analysis for age, residency, comorbidity, BMI, and menopause. In conclusion, we discovered that AR and DM show mutual inverse associations, regardless of sex, in individuals aged 30 years and older.
format	article
author	Tae Kyung Lee Ye Jin Jeon Sun Jae Jung
author_facet	Tae Kyung Lee Ye Jin Jeon Sun Jae Jung
author_sort	Tae Kyung Lee
title	Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea
title_short	Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea
title_full	Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea
title_fullStr	Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea
title_full_unstemmed	Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea
title_sort	bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of south korea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e248fa6dfaf6435cac120d6003d05a44
work_keys_str_mv	AT taekyunglee bidirectionalassociationbetweenallergicrhinitisanddiabetesmellitusfromthenationalrepresentativedataofsouthkorea AT yejinjeon bidirectionalassociationbetweenallergicrhinitisanddiabetesmellitusfromthenationalrepresentativedataofsouthkorea AT sunjaejung bidirectionalassociationbetweenallergicrhinitisanddiabetesmellitusfromthenationalrepresentativedataofsouthkorea
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Bi-directional association between allergic rhinitis and diabetes mellitus from the national representative data of South Korea

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