Spectroscopic studies on photodegradation of atorvastatin calcium

Abstract In this work, the photodegradation process of atorvastatin calcium (ATC) is reported as depending on: (1) the presence and the absence of excipients in the solid state; (2) the chemical interaction of ATC with phosphate buffer (PB) having pH equal to 7 and 8; and (3) hydrolysis reaction of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Madalina Oprica, Miruna Iota, Monica Daescu, Szilard N. Fejer, Catalin Negrila, Mihaela Baibarac
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e249d59e093145e5b55245204fee2f94
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e249d59e093145e5b55245204fee2f94
record_format	dspace
spelling	oai:doaj.org-article:e249d59e093145e5b55245204fee2f942021-12-02T16:31:48ZSpectroscopic studies on photodegradation of atorvastatin calcium10.1038/s41598-021-94693-52045-2322https://doaj.org/article/e249d59e093145e5b55245204fee2f942021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94693-5https://doaj.org/toc/2045-2322Abstract In this work, the photodegradation process of atorvastatin calcium (ATC) is reported as depending on: (1) the presence and the absence of excipients in the solid state; (2) the chemical interaction of ATC with phosphate buffer (PB) having pH equal to 7 and 8; and (3) hydrolysis reaction of ATC in the presence of aqueous solution of NaOH. The novelty of this work consists in the monitoring of the ATC photodegradation by photoluminescence (PL). The exposure of ATC in solid state to UV light induces the photo-oxygenation reactions in the presence of water vapors and oxygen from air. According to the X-ray photoelectron spectroscopic studies, we demonstrate that the photo-oxygenation reaction leads to photodegradation compounds having a high share of C=O bonds compared to ATC before exposure to UV light. Both in the presence of PB and NaOH, the photodegradation process of ATC is highlighted by a significant decrease in the intensity of the PL and photoluminescence excitation (PLE) spectra. According to PLE spectra, the exposure of ATC in the presence of NaOH to UV light leads to the appearance of a new band in the spectral range 340–370 nm, this belonging to the photodegradation products. Arguments concerning the chemical compounds, that resulted in this last case, are shown by Raman scattering and FTIR spectroscopy.Madalina OpricaMiruna IotaMonica DaescuSzilard N. FejerCatalin NegrilaMihaela BaibaracNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Madalina Oprica Miruna Iota Monica Daescu Szilard N. Fejer Catalin Negrila Mihaela Baibarac Spectroscopic studies on photodegradation of atorvastatin calcium
description	Abstract In this work, the photodegradation process of atorvastatin calcium (ATC) is reported as depending on: (1) the presence and the absence of excipients in the solid state; (2) the chemical interaction of ATC with phosphate buffer (PB) having pH equal to 7 and 8; and (3) hydrolysis reaction of ATC in the presence of aqueous solution of NaOH. The novelty of this work consists in the monitoring of the ATC photodegradation by photoluminescence (PL). The exposure of ATC in solid state to UV light induces the photo-oxygenation reactions in the presence of water vapors and oxygen from air. According to the X-ray photoelectron spectroscopic studies, we demonstrate that the photo-oxygenation reaction leads to photodegradation compounds having a high share of C=O bonds compared to ATC before exposure to UV light. Both in the presence of PB and NaOH, the photodegradation process of ATC is highlighted by a significant decrease in the intensity of the PL and photoluminescence excitation (PLE) spectra. According to PLE spectra, the exposure of ATC in the presence of NaOH to UV light leads to the appearance of a new band in the spectral range 340–370 nm, this belonging to the photodegradation products. Arguments concerning the chemical compounds, that resulted in this last case, are shown by Raman scattering and FTIR spectroscopy.
format	article
author	Madalina Oprica Miruna Iota Monica Daescu Szilard N. Fejer Catalin Negrila Mihaela Baibarac
author_facet	Madalina Oprica Miruna Iota Monica Daescu Szilard N. Fejer Catalin Negrila Mihaela Baibarac
author_sort	Madalina Oprica
title	Spectroscopic studies on photodegradation of atorvastatin calcium
title_short	Spectroscopic studies on photodegradation of atorvastatin calcium
title_full	Spectroscopic studies on photodegradation of atorvastatin calcium
title_fullStr	Spectroscopic studies on photodegradation of atorvastatin calcium
title_full_unstemmed	Spectroscopic studies on photodegradation of atorvastatin calcium
title_sort	spectroscopic studies on photodegradation of atorvastatin calcium
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e249d59e093145e5b55245204fee2f94
work_keys_str_mv	AT madalinaoprica spectroscopicstudiesonphotodegradationofatorvastatincalcium AT mirunaiota spectroscopicstudiesonphotodegradationofatorvastatincalcium AT monicadaescu spectroscopicstudiesonphotodegradationofatorvastatincalcium AT szilardnfejer spectroscopicstudiesonphotodegradationofatorvastatincalcium AT catalinnegrila spectroscopicstudiesonphotodegradationofatorvastatincalcium AT mihaelabaibarac spectroscopicstudiesonphotodegradationofatorvastatincalcium
_version_	1718383904452247552

Spectroscopic studies on photodegradation of atorvastatin calcium

Ejemplares similares