Evaluation of Sperm Quality and Serum Parameters in Sertraline-Exposed Mice and Protective Role of Vitamin E

BACKGROUND AND OBJECTIVE: Sertraline is one of the antidepressants whose effects on the reproductive system has faced controversial reports. This study was performed to evaluate the efficacy of vitamin E against sertraline-induced injuries on serum and sperm parameters. METHODS: In this experimental...

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Autores principales:	F Morshedi, H Morovvati, J Sadeghinezhad, M Taheri, H Anbara
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	vitamin e sertraline sperm testosterone mice Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e24ee4f94aa4474a9ebfc3bf66d7ad39
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spelling	oai:doaj.org-article:e24ee4f94aa4474a9ebfc3bf66d7ad392021-11-09T10:15:54ZEvaluation of Sperm Quality and Serum Parameters in Sertraline-Exposed Mice and Protective Role of Vitamin E1561-41072251-7170https://doaj.org/article/e24ee4f94aa4474a9ebfc3bf66d7ad392020-03-01T00:00:00Zhttp://jbums.org/article-1-8546-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Sertraline is one of the antidepressants whose effects on the reproductive system has faced controversial reports. This study was performed to evaluate the efficacy of vitamin E against sertraline-induced injuries on serum and sperm parameters. METHODS: In this experimental study, 40 adult male mice were divided into eight groups of 5. Four groups of mice received vitamin E at 100 international units per kg body weight via gavage for 42 days. In three of the above groups, sertraline was administered orally at 5, 10 and 20 mg/kg body weight four hours after receiving vitamin E. One group was considered as the control group. Twenty-four hours after the final treatment, blood samples were collected from the heart and sperm quality parameters including count, motility, viability, chromatin density, abnormal forms, and sperm DNA damage were measured. FINDINGS: Sertraline significantly increased abnormal sperm (25.8±2.04) and significantly decreased the count (30.2±2.77), motility (68.30±2.94), viability (75.4±3.20) and maturation (84.0±1.58) of sperm compared to control group (10.4±1.14, 39.6±2.07, 89.37±1.87, 92.6±3.71, and 97.4±1.14, respectively) (P<0.05). Vitamin E administration significantly improved abnormal sperm (17.8±2.28), count (37.2±1.92), motility (78.27±2.10), viability (83.2±2.38) and maturation (83.4±1.81) of sperm (p<0.05). CONCLUSION: The results of this study showed that vitamin E decreases the reproductive toxicity of sertraline in mice by improving serum and sperm parameters.F MorshediH MorovvatiJ SadeghinezhadM TaheriH AnbaraBabol University of Medical Sciencesarticlevitamin esertralinespermtestosteronemiceMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	vitamin e sertraline sperm testosterone mice Medicine R Medicine (General) R5-920
spellingShingle	vitamin e sertraline sperm testosterone mice Medicine R Medicine (General) R5-920 F Morshedi H Morovvati J Sadeghinezhad M Taheri H Anbara Evaluation of Sperm Quality and Serum Parameters in Sertraline-Exposed Mice and Protective Role of Vitamin E
description	BACKGROUND AND OBJECTIVE: Sertraline is one of the antidepressants whose effects on the reproductive system has faced controversial reports. This study was performed to evaluate the efficacy of vitamin E against sertraline-induced injuries on serum and sperm parameters. METHODS: In this experimental study, 40 adult male mice were divided into eight groups of 5. Four groups of mice received vitamin E at 100 international units per kg body weight via gavage for 42 days. In three of the above groups, sertraline was administered orally at 5, 10 and 20 mg/kg body weight four hours after receiving vitamin E. One group was considered as the control group. Twenty-four hours after the final treatment, blood samples were collected from the heart and sperm quality parameters including count, motility, viability, chromatin density, abnormal forms, and sperm DNA damage were measured. FINDINGS: Sertraline significantly increased abnormal sperm (25.8±2.04) and significantly decreased the count (30.2±2.77), motility (68.30±2.94), viability (75.4±3.20) and maturation (84.0±1.58) of sperm compared to control group (10.4±1.14, 39.6±2.07, 89.37±1.87, 92.6±3.71, and 97.4±1.14, respectively) (P<0.05). Vitamin E administration significantly improved abnormal sperm (17.8±2.28), count (37.2±1.92), motility (78.27±2.10), viability (83.2±2.38) and maturation (83.4±1.81) of sperm (p<0.05). CONCLUSION: The results of this study showed that vitamin E decreases the reproductive toxicity of sertraline in mice by improving serum and sperm parameters.
format	article
author	F Morshedi H Morovvati J Sadeghinezhad M Taheri H Anbara
author_facet	F Morshedi H Morovvati J Sadeghinezhad M Taheri H Anbara
author_sort	F Morshedi
title	Evaluation of Sperm Quality and Serum Parameters in Sertraline-Exposed Mice and Protective Role of Vitamin E
title_short	Evaluation of Sperm Quality and Serum Parameters in Sertraline-Exposed Mice and Protective Role of Vitamin E
title_full	Evaluation of Sperm Quality and Serum Parameters in Sertraline-Exposed Mice and Protective Role of Vitamin E
title_fullStr	Evaluation of Sperm Quality and Serum Parameters in Sertraline-Exposed Mice and Protective Role of Vitamin E
title_full_unstemmed	Evaluation of Sperm Quality and Serum Parameters in Sertraline-Exposed Mice and Protective Role of Vitamin E
title_sort	evaluation of sperm quality and serum parameters in sertraline-exposed mice and protective role of vitamin e
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/e24ee4f94aa4474a9ebfc3bf66d7ad39
work_keys_str_mv	AT fmorshedi evaluationofspermqualityandserumparametersinsertralineexposedmiceandprotectiveroleofvitamine AT hmorovvati evaluationofspermqualityandserumparametersinsertralineexposedmiceandprotectiveroleofvitamine AT jsadeghinezhad evaluationofspermqualityandserumparametersinsertralineexposedmiceandprotectiveroleofvitamine AT mtaheri evaluationofspermqualityandserumparametersinsertralineexposedmiceandprotectiveroleofvitamine AT hanbara evaluationofspermqualityandserumparametersinsertralineexposedmiceandprotectiveroleofvitamine
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Evaluation of Sperm Quality and Serum Parameters in Sertraline-Exposed Mice and Protective Role of Vitamin E

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