Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms

Deep brain stimulation (DBS) is a symptomatic treatment of Parkinson’s disease (PD) that benefits only a minority of patients. Here, the authors show that activation of cortical somatostatin interneurons alleviates motor symptoms in a mouse model of PD and may constitute a less invasive alternative...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sébastien Valverde, Marie Vandecasteele, Charlotte Piette, Willy Derousseaux, Giuseppe Gangarossa, Asier Aristieta Arbelaiz, Jonathan Touboul, Bertrand Degos, Laurent Venance
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e24ff63da61d4a89a39adb5c41f76a14
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e24ff63da61d4a89a39adb5c41f76a14
record_format	dspace
spelling	oai:doaj.org-article:e24ff63da61d4a89a39adb5c41f76a142021-12-02T17:15:59ZDeep brain stimulation-guided optogenetic rescue of parkinsonian symptoms10.1038/s41467-020-16046-62041-1723https://doaj.org/article/e24ff63da61d4a89a39adb5c41f76a142020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16046-6https://doaj.org/toc/2041-1723Deep brain stimulation (DBS) is a symptomatic treatment of Parkinson’s disease (PD) that benefits only a minority of patients. Here, the authors show that activation of cortical somatostatin interneurons alleviates motor symptoms in a mouse model of PD and may constitute a less invasive alternative than DBS.Sébastien ValverdeMarie VandecasteeleCharlotte PietteWilly DerousseauxGiuseppe GangarossaAsier Aristieta ArbelaizJonathan TouboulBertrand DegosLaurent VenanceNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sébastien Valverde Marie Vandecasteele Charlotte Piette Willy Derousseaux Giuseppe Gangarossa Asier Aristieta Arbelaiz Jonathan Touboul Bertrand Degos Laurent Venance Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms
description	Deep brain stimulation (DBS) is a symptomatic treatment of Parkinson’s disease (PD) that benefits only a minority of patients. Here, the authors show that activation of cortical somatostatin interneurons alleviates motor symptoms in a mouse model of PD and may constitute a less invasive alternative than DBS.
format	article
author	Sébastien Valverde Marie Vandecasteele Charlotte Piette Willy Derousseaux Giuseppe Gangarossa Asier Aristieta Arbelaiz Jonathan Touboul Bertrand Degos Laurent Venance
author_facet	Sébastien Valverde Marie Vandecasteele Charlotte Piette Willy Derousseaux Giuseppe Gangarossa Asier Aristieta Arbelaiz Jonathan Touboul Bertrand Degos Laurent Venance
author_sort	Sébastien Valverde
title	Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms
title_short	Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms
title_full	Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms
title_fullStr	Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms
title_full_unstemmed	Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms
title_sort	deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e24ff63da61d4a89a39adb5c41f76a14
work_keys_str_mv	AT sebastienvalverde deepbrainstimulationguidedoptogeneticrescueofparkinsoniansymptoms AT marievandecasteele deepbrainstimulationguidedoptogeneticrescueofparkinsoniansymptoms AT charlottepiette deepbrainstimulationguidedoptogeneticrescueofparkinsoniansymptoms AT willyderousseaux deepbrainstimulationguidedoptogeneticrescueofparkinsoniansymptoms AT giuseppegangarossa deepbrainstimulationguidedoptogeneticrescueofparkinsoniansymptoms AT asieraristietaarbelaiz deepbrainstimulationguidedoptogeneticrescueofparkinsoniansymptoms AT jonathantouboul deepbrainstimulationguidedoptogeneticrescueofparkinsoniansymptoms AT bertranddegos deepbrainstimulationguidedoptogeneticrescueofparkinsoniansymptoms AT laurentvenance deepbrainstimulationguidedoptogeneticrescueofparkinsoniansymptoms
_version_	1718381232722542592

Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms

Ejemplares similares