Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs

Qin Wang,1 Shanshan Liu,1 Fan Yang,2 Lu Gan,3 Xiangliang Yang,3 Yajiang Yang1 1National Engineering Research Center for Nanomedicine, School of Chemistry and Chemical Engineering, 2Department of Radiology, Union Hospital, Tongji Medical College, 3National Engineering Research Center for Nanomedicin...

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Autores principales:	Wang Q, Liu S, Yang F, Gan L, Yang X, Yang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	MRI visuality chemoembolization microfluidics dual-drug Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e252dd5e62224aff808861b2e916c149
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spelling	oai:doaj.org-article:e252dd5e62224aff808861b2e916c1492021-12-02T05:14:22ZMagnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs1178-2013https://doaj.org/article/e252dd5e62224aff808861b2e916c1492017-06-01T00:00:00Zhttps://www.dovepress.com/magnetic-alginate-microspheres-detected-by-mri-fabricated-using-microf-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Qin Wang,1 Shanshan Liu,1 Fan Yang,2 Lu Gan,3 Xiangliang Yang,3 Yajiang Yang1 1National Engineering Research Center for Nanomedicine, School of Chemistry and Chemical Engineering, 2Department of Radiology, Union Hospital, Tongji Medical College, 3National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China Abstract: Alginate microspheres loaded with superparamagnetic iron oxide nanoparticles (SPIO NPs) have been fabricated by a T-junction microfluidic device combined with an external ionic crosslinking. The obtained microspheres possess excellent visuality under magnetic resonance due to the presence of only 0.6 mg/mL SPIO NPs. The microspheres also show uniform size with narrow distribution and regular spherical shape characterized by optic microscope and environmental scanning electron microscope. Furthermore, dual drugs (5-fluorouracil and doxorubicin hydrochloride) have been loaded within the microspheres. The release behavior of dual drugs from the microspheres show typical sustained release profiles. As a novel embolic agent, such microspheres in blood vessels can be tracked by magnetic resonance scanner. Thus, the integration of embolotherapy, chemotherapy, and postoperative diagnosis can be realized. Keywords: MRI visuality, chemoembolization, microfluidics, dual drugs, alginate microspheres Wang QLiu SYang FGan LYang XYang YDove Medical PressarticleMRI visualitychemoembolizationmicrofluidicsdual-drugMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4335-4347 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	MRI visuality chemoembolization microfluidics dual-drug Medicine (General) R5-920
spellingShingle	MRI visuality chemoembolization microfluidics dual-drug Medicine (General) R5-920 Wang Q Liu S Yang F Gan L Yang X Yang Y Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs
description	Qin Wang,1 Shanshan Liu,1 Fan Yang,2 Lu Gan,3 Xiangliang Yang,3 Yajiang Yang1 1National Engineering Research Center for Nanomedicine, School of Chemistry and Chemical Engineering, 2Department of Radiology, Union Hospital, Tongji Medical College, 3National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China Abstract: Alginate microspheres loaded with superparamagnetic iron oxide nanoparticles (SPIO NPs) have been fabricated by a T-junction microfluidic device combined with an external ionic crosslinking. The obtained microspheres possess excellent visuality under magnetic resonance due to the presence of only 0.6 mg/mL SPIO NPs. The microspheres also show uniform size with narrow distribution and regular spherical shape characterized by optic microscope and environmental scanning electron microscope. Furthermore, dual drugs (5-fluorouracil and doxorubicin hydrochloride) have been loaded within the microspheres. The release behavior of dual drugs from the microspheres show typical sustained release profiles. As a novel embolic agent, such microspheres in blood vessels can be tracked by magnetic resonance scanner. Thus, the integration of embolotherapy, chemotherapy, and postoperative diagnosis can be realized. Keywords: MRI visuality, chemoembolization, microfluidics, dual drugs, alginate microspheres
format	article
author	Wang Q Liu S Yang F Gan L Yang X Yang Y
author_facet	Wang Q Liu S Yang F Gan L Yang X Yang Y
author_sort	Wang Q
title	Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs
title_short	Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs
title_full	Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs
title_fullStr	Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs
title_full_unstemmed	Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs
title_sort	magnetic alginate microspheres detected by mri fabricated using microfluidic technique and release behavior of encapsulated dual drugs
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e252dd5e62224aff808861b2e916c149
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Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs

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