Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure

Abstract Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients with cardiovascular disorders who underwent...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hirotake Takahashi, Yusuke Kashiwagi, Tomohisa Nagoshi, Yoshiro Tanaka, Yuhei Oi, Haruka Kimura, Kousuke Minai, Michihiro Yoshimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e254922173444f8ebb477b4401e1a665
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e254922173444f8ebb477b4401e1a665
record_format	dspace
spelling	oai:doaj.org-article:e254922173444f8ebb477b4401e1a6652021-11-14T12:20:20ZLow triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure10.1038/s41598-021-01454-52045-2322https://doaj.org/article/e254922173444f8ebb477b4401e1a6652021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01454-5https://doaj.org/toc/2045-2322Abstract Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients with cardiovascular disorders who underwent cardiac catheterization. A multiple regression analysis revealed that the left ventricular ejection fraction (LVEF), hemoglobin (Hb) levels, sex (male), free T3 (FT3) levels, and estimated glomerular filtration rate (eGFR) were significantly negatively associated with the log BNP value, while age was significantly positively associated with the log BNP value (P < 0.001 each). Furthermore, the log BNP and age were significantly negatively associated with the FT3 levels, while the Hb and body mass index (BMI) were significantly positively associated with the FT3 levels (P < 0.001 each). Theoretically constructed structure equation modeling (SEM) revealed an inverse association between FT3 and BNP (β = −0.125, P = 0.002), and the same relationship remained in the patient group with normal-range BNP values (β = −0.198, P = 0.008). We demonstrated a significant relationship between high BNP and low serum FT3 levels, and this relationship remained significant in patients with normal BNP levels. These results indicate that low T3 is associated with high plasma BNP levels rather than worsening of hemodynamics.Hirotake TakahashiYusuke KashiwagiTomohisa NagoshiYoshiro TanakaYuhei OiHaruka KimuraKousuke MinaiMichihiro YoshimuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hirotake Takahashi Yusuke Kashiwagi Tomohisa Nagoshi Yoshiro Tanaka Yuhei Oi Haruka Kimura Kousuke Minai Michihiro Yoshimura Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure
description	Abstract Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients with cardiovascular disorders who underwent cardiac catheterization. A multiple regression analysis revealed that the left ventricular ejection fraction (LVEF), hemoglobin (Hb) levels, sex (male), free T3 (FT3) levels, and estimated glomerular filtration rate (eGFR) were significantly negatively associated with the log BNP value, while age was significantly positively associated with the log BNP value (P < 0.001 each). Furthermore, the log BNP and age were significantly negatively associated with the FT3 levels, while the Hb and body mass index (BMI) were significantly positively associated with the FT3 levels (P < 0.001 each). Theoretically constructed structure equation modeling (SEM) revealed an inverse association between FT3 and BNP (β = −0.125, P = 0.002), and the same relationship remained in the patient group with normal-range BNP values (β = −0.198, P = 0.008). We demonstrated a significant relationship between high BNP and low serum FT3 levels, and this relationship remained significant in patients with normal BNP levels. These results indicate that low T3 is associated with high plasma BNP levels rather than worsening of hemodynamics.
format	article
author	Hirotake Takahashi Yusuke Kashiwagi Tomohisa Nagoshi Yoshiro Tanaka Yuhei Oi Haruka Kimura Kousuke Minai Michihiro Yoshimura
author_facet	Hirotake Takahashi Yusuke Kashiwagi Tomohisa Nagoshi Yoshiro Tanaka Yuhei Oi Haruka Kimura Kousuke Minai Michihiro Yoshimura
author_sort	Hirotake Takahashi
title	Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure
title_short	Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure
title_full	Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure
title_fullStr	Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure
title_full_unstemmed	Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure
title_sort	low triiodothyronine levels correlate with high b-type natriuretic peptide levels in patients with heart failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e254922173444f8ebb477b4401e1a665
work_keys_str_mv	AT hirotaketakahashi lowtriiodothyroninelevelscorrelatewithhighbtypenatriureticpeptidelevelsinpatientswithheartfailure AT yusukekashiwagi lowtriiodothyroninelevelscorrelatewithhighbtypenatriureticpeptidelevelsinpatientswithheartfailure AT tomohisanagoshi lowtriiodothyroninelevelscorrelatewithhighbtypenatriureticpeptidelevelsinpatientswithheartfailure AT yoshirotanaka lowtriiodothyroninelevelscorrelatewithhighbtypenatriureticpeptidelevelsinpatientswithheartfailure AT yuheioi lowtriiodothyroninelevelscorrelatewithhighbtypenatriureticpeptidelevelsinpatientswithheartfailure AT harukakimura lowtriiodothyroninelevelscorrelatewithhighbtypenatriureticpeptidelevelsinpatientswithheartfailure AT kousukeminai lowtriiodothyroninelevelscorrelatewithhighbtypenatriureticpeptidelevelsinpatientswithheartfailure AT michihiroyoshimura lowtriiodothyroninelevelscorrelatewithhighbtypenatriureticpeptidelevelsinpatientswithheartfailure
_version_	1718429320151564288

Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure

Ejemplares similares