Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

The cancer immunoediting hypothesis assumes the immune system sculpts the cancer genome. Here the authors show, in a mouse model, that neutral evolution outweighs the effects of immunoselection and that immune checkpoint blockade potentiates the immunoediting, switching the system to non-neutral evo...

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Autores principales:	Mirjana Efremova, Dietmar Rieder, Victoria Klepsch, Pornpimol Charoentong, Francesca Finotello, Hubert Hackl, Natascha Hermann-Kleiter, Martin Löwer, Gottfried Baier, Anne Krogsdam, Zlatko Trajanoski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e257159229014b539553cb86455044f3
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spelling	oai:doaj.org-article:e257159229014b539553cb86455044f32021-12-02T17:32:01ZTargeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution10.1038/s41467-017-02424-02041-1723https://doaj.org/article/e257159229014b539553cb86455044f32018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02424-0https://doaj.org/toc/2041-1723The cancer immunoediting hypothesis assumes the immune system sculpts the cancer genome. Here the authors show, in a mouse model, that neutral evolution outweighs the effects of immunoselection and that immune checkpoint blockade potentiates the immunoediting, switching the system to non-neutral evolution.Mirjana EfremovaDietmar RiederVictoria KlepschPornpimol CharoentongFrancesca FinotelloHubert HacklNatascha Hermann-KleiterMartin LöwerGottfried BaierAnne KrogsdamZlatko TrajanoskiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mirjana Efremova Dietmar Rieder Victoria Klepsch Pornpimol Charoentong Francesca Finotello Hubert Hackl Natascha Hermann-Kleiter Martin Löwer Gottfried Baier Anne Krogsdam Zlatko Trajanoski Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
description	The cancer immunoediting hypothesis assumes the immune system sculpts the cancer genome. Here the authors show, in a mouse model, that neutral evolution outweighs the effects of immunoselection and that immune checkpoint blockade potentiates the immunoediting, switching the system to non-neutral evolution.
format	article
author	Mirjana Efremova Dietmar Rieder Victoria Klepsch Pornpimol Charoentong Francesca Finotello Hubert Hackl Natascha Hermann-Kleiter Martin Löwer Gottfried Baier Anne Krogsdam Zlatko Trajanoski
author_facet	Mirjana Efremova Dietmar Rieder Victoria Klepsch Pornpimol Charoentong Francesca Finotello Hubert Hackl Natascha Hermann-Kleiter Martin Löwer Gottfried Baier Anne Krogsdam Zlatko Trajanoski
author_sort	Mirjana Efremova
title	Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
title_short	Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
title_full	Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
title_fullStr	Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
title_full_unstemmed	Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
title_sort	targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e257159229014b539553cb86455044f3
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Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

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